CAS: 67392-87-4; Drospirenone

上下游产品

17α-(3-hydroxypropyl)-6β,7β;15β,16β-dimethylene-5β-androstane-3β,5,17β-triol 3-(17β-hydroxy-6β,7β;15β,16β-dimethylene-3-oxo-4-androstene-17β-yl)propionic acid γ-lactone 25H30O5C25H30O5 3β-hydorxy-15β,16β-methylene androst-5-ene-17-oneSpirorenone 7β-chloromethyl-15β,16β-methylene-3-oxo-17β-pregn-4-ene-21,17-carbolactone 7β-chloromethyl-15β,16β-methylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone

6β,7β;15β,16β-Dimethylene-17β-Dihydroxy-17α-(2-Carbonyl)-Ethyl-Androst-4-En-3-One置于对甲苯磺酸体系中,用 乙酸乙酯 作为反应溶剂,化学反应 1.0H,反应生成 屈螺酮
参考文献: Process For Obtaining 17-Spirolactones In Steroids[fr] Procédé D'Obtention De 17-Spirolactones Dans Des Stéroïdes
标题: Process For Obtaining 17-Spirolactones In Steroids[fr] Procédé D'Obtention De 17-Spirolactones Dans Des Stéroïdes
摘要:该发明涉及获取17位上具有螺内酯基团的类固醇的过程,特别是工业上获取6β,7β; 15β,16β-二甲烯-3-酮-17α-孕-4-烯-21,17-碳内酯,通常称为drospirenone,以及在该过程中有用的中间体.

专利信息

专利号:US-8841283-B2
优先权日:2010-08-03
标 题 :Methods for the preparation of drospirenone and intermediates thereof
发明人：MONTORSI MAURO; MARIANI EDOARDO; GAMBARIN LUCA; ORRU′ GIANMAURO; SCALAPRICE ROMEO; MERLO MASSIMO; ANDRIOLO ERIKA
权利人:MONTORSI MAURO; MARIANI EDOARDO; GAMBARIN LUCA; ORRU′ GIANMAURO; SCALAPRICE ROMEO; MERLO MASSIMO; ANDRIOLO ERIKA; NEWCHEM S P A
摘要:The invention relates to a process for the preparation of Drospirenone in high yields and purity starting from a compound of formula 2 n n n n n n n n n n n n wherein R is a hydroxyl protective group as defined in the claims, through a sequence of oxidation, deprotection, lactonization and water elimination steps, and wherein the steps of oxidation and lactonization are performed with 1,3,5-trichloro1,3,5-triazine-2,4,6-(1H,3H,5H)-trione (trichloroisocyanuric acid, TCCA) or 1,3-dichloro-1,3,5-triazine-2,4,6-(1H,3H,5H)-trione (dichloroisocyanuric acid, DCCA) or an alkaline metal salt thereof such as the sodium salt dihydrate (DCCA sodium salt) or 1-hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide (IBX). New synthetic intermediates useful for the synthesis of Drospirenone are disclosed, too.

专利号:WO-2014174338-A1
优先权日:2013-04-22
标 题:Process for preparing an intermediate useful in the production of drospirenone
发明人：LENNA ROBERTO; BARBIERI FRANCESCO; LUONI MARIA GIOVANNA; NOSEDA MONICA
权利人:IND CHIMICA SRL
摘要:A process is described wherein, using 17α-(3-hydroxyprapyl)-6β,7β,15β,16β- dimethylene-5β-androstane-3β,5,17β-triol (III) as starting product, there is obtained 3β,5-dihydroxy-6β,7β,15β,16β-dimethylene-5β-17α-pregna-21, 17-carbolactone (I), a useful intermediate in the synthesis of the compound drospirenone, having contraceptive action: (Formula III & I) (III) (I)