CAS: 773-64-8; 2-Mesitylenesulfonyl Chloride

上下游产品

1,3,5-trimethyl-benzene aluminium trichloride sulfuryl dichloride thionyl chloride 1-(2,4,6-trimethyl-benzenesulfonyl)-piperidine phenyl 2,4,6-trimethylbenzenesulfonate bis(2,4,6-trimethylphenyl)disulfide 2,4,6-trimethylbenzenesulphinic acid

均三甲苯置于氯磺酸,Sodium Chloride体系中,用85%的收率获得产物2,4,6-三甲基苯磺酰氯
参考文献:芳烃磺酰氯的丙烷分解:磺酰硫处的亲核取代
标题:芳烃磺酰氯的丙烷分解:磺酰硫处的亲核取代
摘要:我们研究了在303-323 K时丙-1-醇和丙-2-醇对芳烃磺酰氯的溶剂分解机理.动力学曲线适合一阶动力学.反应性随供电子取代基的增加而增加.芳烃磺酰氯的邻烷基取代衍生物显示出增加的反应性,但这种"正向"邻效应的起源仍不清楚.可能,邻位甲基限制了绕c键的旋转,从而促进了亲核试剂的攻击.就亲核性空间效应而言,未发现丙-1-醇和丙-2-醇的相关反应性变化.所有底物的等动力学关系的存在表明该系列的单一机制.两种醇中所有底物的溶剂分解反应均显示等速温度(t Iso)接近工作温度范围,这表明该过程受到次级反应性因素的影响,该因素可能是ts中的空间性质.溶剂化在该反应中起重要作用,调节反应性.在一些情况下,存在吨-Bu代替我在对位位置导致第一溶剂化壳的变化,从而增加了反应能量(约1 Kj.mol-1).所得结果表明,芳烃磺酰氯对丙-1-醇和丙-2-醇的溶剂化动力学机制与在meoh和etoh中相同,其中双分子亲核取代(s
DOI:10.1002/poc.3753

专利信息

专利号:US-2004242897-A1
优先权日:2002-07-31
标题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-5204456-A
优先权日:1986-04-08
标题:Derivatives of nucleosides and their use for the synthesis of oligonucleotides
发明人：MOLKO DIDIER; SCHULHOF JEAN-CLAUDE; TEOULE ROBERT
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:The invention relates to derivatives of nucleosides and their use for the synthesis of oligonucleotides. These derivatives are in accordance with the formula: (I) in which B represents a radical derived from guanine, cytosine or adenine, whose exocylic NH group is protected by the group with R1 representing a hydrogen atom or a alkyl radical and R2 a hydrogen atom, and alkyl radical, an alkoxy radical and optionally substituted aryloxy radical, R3 represents a hydrogen atom, the dimethoxytrityl radical or the radical R4 represents a hydrogen atom, the radical of formula: or a radical suitable for the synthesis of polynucelotides and R5 represents a hydrogen atom or the protected or unprotected hydroxyl OH radical.

专利号:US-9783549-B2
优先权日:2013-11-04
标题:Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E; LEE JAEMOON
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

专利号:WO-2004011474-A1
优先权日:2002-07-31
标题:Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-6653468-B1
优先权日:2002-07-31
标 题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-4780504-A
优先权日:1985-06-20
标 题 :Supports useful in solid phase synthesis of oligonucleotides
发明人：BUENDIA JEAN; NIERAT JEANINE
权利人:ROUSSEL UCLAF
摘要:Novel supports useful in solid phase synthesis of oligonucleotides of the formula I +TR wherein &cir& is micro pellets of a material selected from the group consisting of glass, silica, Kieselguhr, polytetrafluoroethylene, cellulose and metallic oxides, m is an integer from 1 to 20, A is selected from the group consisting of alkylene of 1 to 20 carbon atoms, saturated cycloalkylene of 3 to 12 carbon atoms, phenyl and 5 to 6 member heterocycles, x is an integer from 0 to 20, x1 is an integer from 0 to 10 and the amino group may be in the m-, p- or o-position, a process for the preparation of said supports, the use of said supports and intermediates.