CAS: 14704-31-5; 3-Phenylbenzyl Bromide

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CAS号643-93-6 3-甲基联苯 | CAS号103668-94-6 6-phenyl-2-oxat... | CAS号69605-90-9 3-联苯甲醇 | CAS号7789-60-8 三溴化磷 | CAS号591-51-5 苯基锂 | CAS号103668-90-2 (1R,2S,5R,7S)-6... | CAS号92-52-4 联苯 | CAS号7726-95-6 溴素 | CAS号23948-77-8 2-([1,1'-联苯]-3-基)乙酸 | CAS号69605-90-9 3-联苯甲醇 | CAS号1204-60-0 联苯基-3-甲醛 | CAS号790-22-7 3-Benzyl-1,1'-b...

3-甲基联苯置于n-溴代丁二酰亚胺(Nbs),过氧化氢苯甲酰体系中,用 四氯化碳 用作溶剂,化学反应生成3-苯基苄基溴
参考文献:用n-氟苯磺酰亚胺通过苄基膦酸酯的α-碳负离子的亲电氟化反应合成芳基(二氟亚甲基膦酸酯)
标题:用n-氟苯磺酰亚胺通过苄基膦酸酯的α-碳负离子的亲电氟化反应合成芳基(二氟亚甲基膦酸酯)
摘要:研发了多种苄基膦酸酯与n-氟苯磺酰亚胺的亲电子氟化.在一系列官能团如硝基,溴,酮,酯,苯基和醚基的存在下,氟化反应进行得很好.也可以制备含有两个α,α-二氟亚甲基膦酸酯基的苯基和联苯衍生物.该方法与甲基或乙基膦酸酯相容,但是与叔丁基酯或在对位处含有另外的苄基部分的苄基膦酸酯不相容.
Doi:10.1016/s0040-4020(97)10395-7

专利信息

专利号:US-11767302-B2
优先权日:2020-10-01
标题 :Reagents and methods for tetrazine synthesis
发明人：FOX JOSEPH M; LAMBERT WILLIAM; FANG YINZHI; AM ENDE CHRISTOPHER WILLIAM; MAHAPATRA SUBHAM; XIE YIXIN; WANG CHUANQI
权利人:UNIV DELAWARE
摘要:Disclosed herein are mono- and di-substituted tetrazines and methods of their preparation and converting an oxetanyl ester to a thio-substituted tetrazine, which is then converted to a mono-substituted tetrazine, a di-substituted tetrazine, or a vinylether disubstituted tetrazine.

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:US-5561143-A
优先权日:1995-01-25
标题:Aliphatic amino bis-aryl squalene synthase inhibitors
发明人：GRONEBERG ROBERT A; REGAN JOHN R; NEUENSCHWANDER KENT W; SCOTESE ANTHONY C
权利人:RHONE POULENC RORER PHARMA
摘要:This invention relates to a class of novel aliphatic amino bis-aryl compounds containing at least four carbon atoms and an amino group either substituted thereon or incorporated therein and is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

专利号:WO-9215579-A1
优先权日:1991-03-08
标 题 :Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
发明人：NEUENSCHWANDER KENT; AMIN DILIP; SCOTESE ANTHONY C; MORRIS ROBERT L
权利人:RHONE POULENC RORER INT
摘要:This invention relates to polycyclic compounds containing two mono and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

专利号:US-5534532-A
优先权日:1993-05-21
标题 :Aliphatic amino bis-aryl squalene synthase inhibitors
发明人：GRONEBERG ROBERT A; REGAN JOHN R; NEUENSCHWANDER KENT W; SCOTESE ANTHONY C
权利人:RHONE POULENC RORER PHARMA
摘要:This invention relates to a class of novel aliphatic amino bis-aryl compounds containing at least four carbon atoms and an amino group either substituted thereon or incorporated therein and is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.