专利号:US-6048529-A 优先权日:1991-12-19 标 题 :PVA or PEG conjugates of peptides for epitope-specific immunosuppression 发明人:ATASSI M ZOUHAIR; ASHIZAWA TETSUO 摘要:The invention relates to a procedure for synthesis of well-defined conjugates of peptides to the tolerogenic polymer monomethoxypolyethylene glycol (mPEG) or polyvinyl alcohol (PVA). This method results in the preparation of conjugates in which one molecule of tolerogenic polymer is specifically coupled to one or the other or both of the termini of an otherwise unaltered peptide molecule. A synthetic peptide synthesized using this method and corresponding to a myasthenogenic region of an acetylcholine receptor was conjugated to monomethoxypolyethylene glycol. Injection of animals with the mPEG-conjugate and subsequent immunization with whole receptor suppressed the development of experimental autoimmune myasthenia gravis (EAMG) by electrophysiological criteria. Specifically-conjugated, tolerogenic peptides are also disclosed for diseases as diverse as ragweed pollen allergy and Grave's disease.
专利号:WO-2005056789-A1 优先权日:2003-12-08 标 题:Cellular membrane composition and method of preparing the same 发明人:DAIMON KATSUYA; KUROITA TOSHIHIRO; INOUE HIROAKI; OKA MASANORI 权利人:TOYO BOSEKI; DAIMON KATSUYA; KUROITA TOSHIHIRO; INOUE HIROAKI; OKA MASANORI 摘要:[PROBLEMS] To improve a cellular membrane composition to be used together with a cell-free protein synthesis system, in particular, a microsomal fraction obtained by fragmentation of endoplasmic reticulum and a method of preparing the same. [MEANS FOR SOLVING PROBLEMS] A cellular membrane composition of a cellular membrane component, which aims at transferring a membrane-targeting protein synthesized by the cell-free protein synthesis method onto a membrane structure or into a membrane structure, prepared in a buffer solution having the compositions (a) and/or (b) as will be mentioned below: (a) containing triethanolamine at a concentration of 40 mM/l or less in the buffer solution; and (b) containing sucrose at a concentration of 0.2 M/l or less therein.
专利号:US-2004232390-A1 优先权日:2003-04-07 标 题 :Highly conductive carbon/inherently conductive polymer composites 发明人:VISWANATHAN TITO 摘要:This invention relates to composites of a highly conductive form of carbon, preferably graphite, and an inherently conducting polymer that exhibits higher conductivity than the conductivities of the individual components and the synthesis of these composites.
专利号:US-2003092901-A1 优先权日:2001-10-24 标题:Efficient synthesis of protein-oligonucleotide conjugates
专利号:US-4035350-A 优先权日:1975-01-30 标 题:Process for the preparation of water-soluble azo dyestuffs by reacting an aromatic amine and a coupling component with alkali metal nitrite or alkyl nitrite in the absence of acid 发明人:LANDLER JOSEF; WORFEL ERHARD 权利人:HOECHST AG 摘要:A new and very advantageous Process had been found for the preparation of azo dyestuffs by diazotation and coupling in which the synthesis is carried out without the hitherto usual addition of an acid, with the proviso that at least one of the diazo and coupling components contains at least one acid group. Besides the saving of reaction material and subsequently of alkali for neutralization of the reaction medium and isolation of the dyestuff, highly concentrated solutions of the dyestuff and salt-free or practically salt-free dyestuffs can be obtained, and waste-water is no longer charged with big amounts of salts.
专利号:WO-03035830-A2 优先权日:2001-10-24 标题 :Efficient synthesis of protein-oligonucleotide conjugates
参考文献:10.1155/2011/797604 摘要:Jendral JA, Monakhova YB, Lachenmeier DW. Formaldehyde in Alcoholic Beverages: Large Chemical Survey Using Purpald Screening Followed by Chromotropic Acid Spectrophotometry with Multivariate Curve Resolution. International Journal of Analytical Chemistry. 2011;2011():1–11. doi: 10.1155/2011/797604.