CAS: 17626-40-3; 3,4-Diaminobenzonitrile

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CAS号99512-10-4 3-氨基-4-硝基苯腈 | CAS号6393-40-4 4-氨基-3-硝基苯甲腈 | CAS号7732-18-5 水 | CAS号35704-19-9 4'-氰基乙酰基苯胺 | CAS号873-74-5 对氨基苯腈 | CAS号29289-18-7 N1-(4-CYANO-2-N... | CAS号89642-49-9 4-溴-3-硝基苯甲腈 | CAS号7647-01-0 盐酸 | CAS号401567-00-8 2-氯-5-氰基苯并咪唑 | CAS号188860-26-6 DMA | CAS号24611-70-9 1H-苯并[d][1,2,3]... | CAS号237429-65-1 (9ci)-2-(2-氨基乙基... | CAS号23623-08-7 HOE 33187 | CAS号237429-61-7 2-(羟甲基)-3H-苯并咪唑-5-甲腈 | CAS号23491-54-5 Hoechst 33258类似物2 | CAS号23491-55-6 Hoechst 33258类似物5 | CAS号61875-40-9 6 -氰基喹喔啉-2,3二酮 | CAS号116568-17-3 1H-苯并[d]咪唑-6-甲酰胺

4-乙酰氨苯甲腈置于palladium On Activated Charcoal 硫酸,氢气,Potassium Nitrate体系中,用 乙醇 用作溶剂,化学反应 6.5H,反应生成3,4-二氨基苯甲腈
参考文献:烷基和芳基连接的双(ami基苯并咪唑)和双(ami基吲哚)的结构,Dna小沟结合和碱基对特异性.
标题:烷基和芳基连接的双(ami基苯并咪唑)和双(ami基吲哚)的结构,Dna小沟结合和碱基对特异性.
摘要:已经制备了一系列具有变化的连接链的双(ami基苯并咪唑)和双(ami基吲哚),所述连接链连接芳族基团并且对碱性a基进行了各种修饰.小牛胸腺(ct)dna和核酸均聚物[poly(da).Poly(dt),Poly(da-Dt).Poly-(da-Dt)和poly(dg-Dc).Poly(dg-Dc) )]已经通过热变性(δtm)和粘度研究了这些化合物的结合性能.该化合物对poly(da).Poly(dt)和poly(da-Dt).Poly(da-Dt)的亲和力大于对poly(dg-Dc).Poly(dg-Dc)的亲和力.粘度滴定表明该化合物不通过嵌入结合.分子模型研究和生物物理数据表明,分子与ct Dna和均聚物的小沟结合.分子形状的分析与这种核酸结合模式一致.与苯并咪唑环相连的亚甲基数量为偶数的化合物比亚甲基数量为奇数的化合物对dna的亲和力更高.确定分子中四个定义的基团的曲率半径的分子模
Doi:10.1021/jm00064A008

专利信息

专利号:EP-1590332-B1
优先权日:2003-01-09
标题:A process for the synthesis of bisbenzimidazoles and their derivatives.
发明人：JAIN AKASH; TAWAR URMILA; CHANDRA RAMESH; DWARAKANATH B S; CHAUDHURY N K; TANDON VIBHA
权利人:UNIV DELHI
摘要:A process for the synthesis of bisbenzimidazoles and its derivations comprising; (i) reacting 5 chloroaniline with zinc dust and acetic anhydride to produce 5 chloroacetanilide; (ii) reacting 5 chloroacetanilide with HN03 to produce 2-nitro-5-chloroacetanilide; (ix) adding sodium methoxide to 2-nitro-5-ch1oroaniline; (x) heating 2-nitro-5-chloroaniline, methyl piperazine, anhydrous K2CO3 and Dimethyl formamide at 100-120°C produce a mixture which is cooled by pouring ice and is filtered to obtain 5-(4'-methylpiperazin-1'-yl)-2-nitroaniline; (xi) treating 5-(4'-methylpiperazin-l'yl)-2-nitroaniline with Pd/C to produce 2-amino-4-(4'-methylpiperazin-1'-yl) aniline; (xii) refluxing a mixture of 2-amino-4-(4'-methylpiperazin-1'yl) aniline and ethyl-4-amino-3-nitrobenzenecarboximidate hydrochloride in presence of ethanol/glacial acetic acid to produce 4-[5'-(4'-methylpiperazin-1'-yl) 15 benzimidazol-2'-yl)-2-nitroaniline; (xiii) treating a solution of 4-[5'-(4'-methylpiperazin-1'-yi) benzimidazol-2'-yl)-2-nitroaniline with palladium on carbon to yield 2-amino-4-[5'-(4'-Methylpiperazin-1'-yl)benzimidazol-2'-yl]aniline; (xiv) heating 2-amino-4-[5'-(4'-Methylpiperazin-1'-yl)benzimidazol-2'-yl]aniline and 3-4-dimethoxy benzaldehyde using nitrobenzene as a solvent at 110-150°C to produce (DMA) i.e 5-(4-methylpiperazin-1-yl)-2-[2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl] benzimidazole; (ix) heating 2-amino-4-[5'-(4'-Methylpiperazin-1'-yl) benzimidazol-2'-YI] aniline and 5-Formyl-[3-methoxy-4-hydroxy benzimidazole] using nitrobenzene at 110°C to 150°C in presence of argon to produce (TBZ) i.e 5-(4-methylpiperazine-1-yl)-2-[2' (2'-(4-hydroxy-3methoxyphenyl)5'benzimidazolyl) -5'- benzimidazolyl] benzimidazole.

专利号:US-9884067-B2
优先权日:2013-03-14
标 题:Androgen receptor down-regulating agents and uses thereof
发明人：NJAR VINCENT C O; GEDIYA LALJI K; PURUSHOTTAMACHAR PURANIK; GODBOLE ABHIJIT; KWEGYIR AFFUL ANDREW; VASAITIS TADAS
权利人:UNIV OF MARYLAND EASTERN SHORE; UNIV JEFFERSON; UNIV MARYLAND
摘要:The present disclosure provides the design and synthesis of novel steroidal compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant. The compounds are potential agents for the treatment of all forms of prostate cancer and other diseases that depend on functional AR.

专利号:US-2018317484-A1
优先权日:2017-05-07
标题:Composition for inhibiting synthesis of mycotoxin without affecting the growth of the fungi
发明人：MEHTA ALKA; BOGA RAMESHBABU; P DHANAMJAYULU
权利人:VIT UNIV; BogaR Laboratories
摘要:A composition for inhibiting the growth of mycotoxins without affecting the growth of fungi is provided. The mycotoxin is an Aflatoxin and the fungus is an Aspergillus . The anti-aflatoxin composition comprises benzimidazole derivatives of Formula, n n n n n n n n n n where the A is hydrogen or C1-C6 alkyl or C6-C14 aryl; B is C1-C10 alkyl or C6-C14 aryl or oxygen, sulfur, nitrogen containing heteroaryl; C and D are hydrogen or C1-C6 alkyl or C1-C6 alkoxyl or C6-C14 aryl; E is hydrogen or nitro or cyano or carboxyl or acetamidoxime or amidoxime or C1-C6 alkyl or C1-C6 alkoxyl or C6-C14 aryl or oxygen, sulfur, and nitrogen containing heteroaryl; F is hydrogen or C1-C6 alkyl or C1-C6 alkoxyl or C6-C14 aryl or oxygen, sulfur, and nitrogen containing heteroaryl, and mixture thereof with corresponding salts.

专利号:US-9742034-B2
优先权日:2012-12-26
标题 :Cyano-benzimidazole salts for electrochemical cells and method for synthesis thereof
发明人：CHERN YAW-TERNG; JENG JYH-LONG; CHEN SZU-YUAN; WEI AN-SHING; HWANG BING-JOE
权利人:UNIV NAT TAIWAN SCIENCE TECH
摘要:The present invention discloses a new metal cyano-substituted benzimidazolide salt having formula (I) and its preparation. This new cyano-substituted benzimidazole derivatives exhibited excellent thermal stability. The organic salt of the present invention were soluble in an alkyl carbonate solvent, such as propylene carbonate (PC), dimethyl carbonate (DMC) and ethylene carbonate (EC)/DMC cosolvent. The non-aqueous electrolyte prepared by mixing the organic metal salt of the present invention with the alkyl carbonate solvent shows high conductivity and excellent electrochemical stability. The non-aqueous electrolyte is suitable for use in primary or secondary rechargeable batteries.

专利号:CN-107954939-B
优先权日:2017-12-07
标 题 :A kind of method for the catalytic synthesis of benzimidazole derivatives of N,N-dimethylaminothioformyl chloride derivatives under microwave radiation

专利号:CN-107954939-A
优先权日:2017-12-07
标 题:A kind of method for the catalytic synthesis of benzimidazole derivatives of N,N-dimethylaminothioformyl chloride derivatives under microwave radiation