专利号:US-3886166-A 优先权日:1972-12-22 标 题:Method for the synthesis of ({35 )-glaziovine 发明人:CASAGRANDE CESARE; CANONICA LUIGI 权利人:SIPHAR SA 摘要:A method is disclosed for synthesizing ( + OR - )-glaziovine, a naturally occurring alkaloid, useful in the therapeutics as an anxiolytic drug. The reaction pattern is the following: WHEREIN OR1 is an ether or ester group, and R2 is a diazo group. Several variants are provided for the different stages of the method and hydrogenation with catalysts and irradiation with visible and UV radiations are employed for preparing certain intermediates and for carrying out the final stage of the method.
专利号:US-8883763-B2 优先权日:2010-03-01 标题 :Use of isoquinolones for preparing drugs, novel isoquinolones and method for synthesising same 发明人:POPOV ANDREI; JUHEM AURÉLIE; FLORENT JEAN-CLAUDE; N GUYEN CHI-HUNG 权利人:POPOV ANDREI; JUHEM AURÉLIE; FLORENT JEAN-CLAUDE; N GUYEN CHI-HUNG; UNIV JOSEPH FOURIER; CENTRE NAT RECH SCIENT; INST CURIE 摘要:The use of isoquinolones for preparing drugs, including novel isoquinolones as well as their synthesis method. In particular, isoquinolone derivatives used in the treatment of pathological angiogenesis, and more particularly of cancer.
专利号:GB-1451377-A 优先权日:1972-12-22 标题 :Method for the synthesis of plus-minus glaziovine
专利号:GB-1453606-A 优先权日:1972-12-22 标题 :Method for synthesis of plus-minus-glaziovine
专利号:US-2012100073-A1 优先权日:2009-05-04 标题 :Pet radiotracers for imaging fatty acid metabolism and storage 发明人:MACH ROBERT H; GROPLER ROBERT JOHN; TU ZHUDE; HERRERO PILAR 权利人:MACH ROBERT H; GROPLER ROBERT JOHN; TU ZHUDE; HERRERO PILAR; UNIV WASHINGTON 摘要:Fatty acid analogue (FAA) molecules comprising positron-emitting radionuclides, salts thereof, and FAA-triglycerides are disclosed. Also disclosed are methods of synthesis, and methods of imaging distribution and metabolism of fatty acids and fatty acid triglycerides.
专利号:EA-032434-B1 优先权日:2010-03-01 标题 :APPLICATION OF IZHOCHINOLONES FOR THE PREPARATION OF MEDICINES, IZHOCHOLONES AND METHOD OF THEIR SYNTHESIS
[参考文献]: Tsung-I Hsu, Et Al. A Novel Derivative Of Betulinic Acid, Syk023, Suppresses Lung Cancer Growth And Malignancy. Oncotarget. 2015 May 30;6(15):13671-87.
合成参考文献
摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025).