CAS: 685-91-6; N,N-Diethylacetamide

上下游产品

ethanol N-ethyl-vinylidenediaminetetra-N-ethyl-vinylidenediamine hexaethylphosphorous triamide acetic anhydride3-hydroxy-3,3-diphenyl-propionic acid diethylamide N,N-diethyl-3-oxobutanamide ethane butanone Amides ( diethylacetamide ethylmagnesium bromide ethyl acetoacetate diethylamine2-benzyl-N,N-diethyl-3-oxobutanamide 2-(2-chloro-benzyl)-acetoacetic acid diethylamide t-diethylcarbamoyl-5-oxo-3-phenyl-cyclohex-3-ene-r-carboxylic acid(+/-)-6t-diethylcarbamoyl-5-oxo-3-phenyl-cyclohex-3-ene-r-carboxylic acid t-diethylcarbamoyl-5-oxo-3-p-tolyl-cyclohex-3-ene-r-carboxylic acid(+/-)-6t-diethylcarbamoyl-5-oxo-3-p-tolyl-cyclohex-3-ene-r-carboxylic acid

N,N-二乙基-2-氯乙酰胺置于氢气,三乙胺体系中,用 甲醇,水 作为反应溶剂,120.0 °C,3.0 Mpa 条件下,反应 95.0H,以90%的收率获得产物n,N-二乙基乙酰胺
参考文献:一种生物质衍生的非贵金属钴催化剂,用于烷基和(杂)芳基卤化物的选择性加氢脱卤
标题:一种生物质衍生的非贵金属钴催化剂,用于烷基和(杂)芳基卤化物的选择性加氢脱卤
摘要:加氢脱卤是一种直接的方法,可以对有害的人为有机卤化物进行排毒,并去除多步合成中使用的卤化物保护基.一种新型的可持续催化材料是由生物废料(壳聚糖)与富含地球的钴盐结合制成的.通过透射电子显微镜,X射线衍射和x射线光电子能谱测量对多相催化剂进行了充分表征,并将其成功应用于烷基卤和(杂)芳基卤化物的加氢脱卤,适用范围广(> 40个实例),并且具有出色的化学选择性氢作为还原剂.这种方法的普遍用途通过不可降解农药和阻燃剂的成功排毒得到证明.而且,
DOI:10.1002/anie.201702478

专利信息

专利号:WO-2021038581-A1
优先权日:2019-08-30
标题 :A one step synthesis of 2-substituted benzo[b]thiophenes
发明人：SEKAR GOVINDASAMY; POONGUZHALI ELAMVAZHUTHI
权利人:INDIAN INST TECH MADRAS
摘要:The invention pertains to a one step synthesis of 2-substituted benzo[ b ]thiophene of general formula wherein the synthesis of 2-substituted benzo[ b ]thiophenes is by reacting the starting materials substituted or unsubstituted 2-halogenobenzaldehyde and substituted or unsubstituted acetyl/phenacyl bromide with a catalyst, a sulphur source and phase transfer catalyst in an aqueous medium with atmospheric air and at temperature in the range of 25°C-30°C.

专利号:US-11459549-B2
优先权日:2018-05-10
标 题:Method for biocatalytic synthesis of Sitagliptin and intermediate thereof
发明人：WU FAHAO; YANG WEN; LI GANG; SHI HONGWEI; GAO YANGZHE; LIU LILI; YUAN ZHIFA
权利人:CHINA FORTUNE WAY COMPANY; NANJING REDWOOD FINE CHEMICAL CO LTD
摘要:Provided is a method for biocatalytic synthesis of Sitagliptin and intermediates thereof, in particular, provided are compounds of Formula (I) and Formula (II), or pharmaceutically acceptable salts thereof, a polypeptide capable of catalyzing conversion of a compound of Formula (I) to a compound of Formula (II), a nucleic acid encoding the polypeptide, a vector and a cell comprising the nucleic acid. In addition, also provided are a method for producing a compound of Formula (II) and Sitagliptin by using the polypeptide and the compound of Formula (I), and a method for preparing the polypeptide.

专利号:US-4739073-A
优先权日:1983-11-04
标题:Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
发明人：KATHAWALA FAIZULLA G
权利人:SANDOZ PHARMACEUTICALS CORP
摘要:Compounds of the formula wherein one of R and Ro is and the other is primary or secondary C1-6alkyl not containing an asymmetric carbon atom, C3-6cycloalkyl or phenyl(CH2)m-, wherein R4 is hydrogen, C1-3alkyl, n-butyl, i-butyl, t-butyl, C1-3alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R5 is hydrogen, C1-3alkyl, C1-3alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R5a is hydrogen, C1-2alkyl, C1-2alkoxy, fluoro or chloro, and m is 1, 2 or 3, with the provisos that both R5 and R5a must be hydrogen when R4 is hydrogen, R5a must be hydrogen when R5 is hydrogen, not more than one of R4 and R5 is trifluoromethyl, not more than one of R4 and R5 is phenoxy, and not more than one of R4 and R5 is benzyloxy, R2 is hydrogen, C1-3alkyl, n-butyl, i-butyl, t-butyl, C3-6cycloalkyl, C1-3alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R3 is hydrogen, C1-3alkyl, C1-3alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, with the provisos that R3 must be hydrogen when R2 is hydrogen, not more than one of R2 and R3 is trifluoromethyl, not more than one of R2 and R3 is phenoxy, and not more than one of R2 and R3 is benzyloxy, X is -(CH2)n- or -CH=CH-, wherein n is 0, 1, 2 or 3, and Z is wherein R6 is hydrogen or C1-3alkyl, and R7 is hydrogen, C1-3alkyl, n-butyl, i-butyl, t-butyl, benzyl or M, wherein M is a pharmaceutically acceptable cation, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level, and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.

专利号:US-3742080-A
优先权日:1969-04-11
标 题 :Rhodium based catalysts for the synthesis of 1,4-dienes
发明人：SU A
权利人:DU PONT
摘要:Improved catalysts are provided for the synthesis of 1,4-dienes from Alpha -monoolefins and conjugated dienes. The catalysts are rhodium (III) salts in combination with amides, phosphoramides, phosphine oxides, or water. The improved catalysts allow control of the trans-cis ratio of the 1,4-diene formed and are operable at useful rates in a wide range of solvent systems, both protonic and aprotic.

专利号:US-9695188-B2
优先权日:2013-12-06
标 题 :Methods useful in the synthesis of halichondrin B analogs
发明人：HU YONGBO; ZHANG HUIMING; CHIBA HIROYUKI; KOMATSU YUKI; LEWIS BRYAN M
权利人:EISAI R&D MAN CO LTD
摘要:In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).

专利号:WO-2015130660-A1
优先权日:2014-02-25
标题 :Synthesis of racemic amphetamine derivatives by cuprate addition reaction with aziridine phosphoramidate compounds
发明人：MECKLER HAROLD; GREGG BRIAN THOMAS; YANG JIE
权利人:Chemapotheca LLC
摘要:The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.