CAS: 86499-96-9; 3-Bromo-4,5-Dihydro-1H-Benzo[b]Azepin-2(3H)-One

上下游产品

CAS号4424-80-0 1,3,4,5-四氢-2H-1... | CAS号56384-59-9 N-(2-bromo-3,4-... | CAS号1056246-70-8 2-bromo-1,2,3,4... | CAS号529-34-0 1-四氢萘酮 | CAS号105260-10-4 2-(2-Oxo-2,3,4,... | CAS号86499-35-6 3-氨基-1,3,4,5-四氢... | CAS号109010-60-8 (S)-3-氨基-2,3,4,... | CAS号137036-55-6 (R)-3-氨基-1,3,4,... | CAS号98626-45-0 3-氨基-2,3,4,5-四氢...

1,3,4,5-四氢-2H-1-苯并氮杂卓-2-酮置于五氯化磷,碘,溴体系中,用 氯仿 作为反应溶剂,化学反应 4.5H,以70.1%的收率获得产物3-溴-1,3,4,5-四氢-2H-1-苯并氮杂卓-2-酮
参考文献:N-Formyl Hydroxylamine Containing Compounds Useful As Ace Inhibitors And/or Nep Inhibitors
标题:N-Formyl Hydroxylamine Containing Compounds Useful As Ace Inhibitors And/or Nep Inhibitors
摘要:提供了具有以下结构的n-甲酰羟胺,其中r为h,烷基,烯基,芳基-(Ch2)P-,杂芳基-(Ch2)P-或环杂芳基-(Ch2)P-;r1为h或cor2,其中r2为烷基,芳基-(Ch2)P-,环杂芳基-(Ch2)P-,杂芳基-(Ch2)P-,烷氧基或环烷基-(Ch2)P-;p为0至8,A为来源于氨基酸的二肽或是具有构象限制的二肽模拟物.上述化合物在治疗高血压,充血性心力衰竭,肾功能衰竭和肝硬化方面具有用途.

专利信息

专利号:WO-2023181054-A1
优先权日:2022-03-19
标 题:Improved process for synthesis of benazepril intermediate
发明人：DESAI PARIMAL HASMUKHLAL; PATRAVALE BHARATKUMAR SURENDRA; KAJALE NITIN BABURAO; GHOGARE KHANDU SHANKAR
权利人:AARTI INDUSTRIES LTD
摘要:The present invention relates to an improved process for the preparation for the stereo-specific preparation of Benazepril intermediate (3S)-3-[[(1S)-1- phenylethyl]amino]-1,3,4,5-tetrahydro-1-benzazepin-2-one of formula (IS). The steps include: heating the compound of Formula (I) (3RS)-[[(1S)-1-phenylethyl]amino]- 1,3,4,5-tetrahydro-1-benzazepin-2-one at a predefined temperature in a predefined solvent followed by separating undissolved desired isomer of formula (IS) from the reaction mixture of step (i); recovering the R-isomer of formula (IR) from the filtrate followed by distilling the filtrate to isolate the compound of R-isomer of formula (IR); racemizing R-isomer of formula (IR) to form racemic mixture of formula (I) and recovering the racemic compound obtained in step (iv) by distilling the solvent of previous step under vacuum and recycling by adding the racemic compound to step (i).

专利号:US-6548665-B2
优先权日:2001-05-18
标 题:Asymmetric synthesis of a key intermediate for making benazepril and analogues thereof
发明人：TSENG WEI-HONG; SCHLOEMER GEORGE
权利人:SCINOPHARM TAIWAN LTD
摘要:The present invention provides a method of converting an intermediate compound to the desired S,S diastereomer for efficiently making benazepril and analogues thereof.

专利号:US-4410520-A
优先权日:1981-11-09
标题 :3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
发明人：WATTHEY JEFFREY W H
权利人:CIBA GEIGY CORP
摘要:Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzaz epin-2-ones and functional derivatives are angiotension converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.

专利号:US-4575503-A
优先权日:1983-02-10
标 题:3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
发明人：WATTHEY JEFFREY W H
权利人:CIBA GEIGY CORP
摘要:Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzaz epin-2-ones and functional derivatives are angiotensin converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.

专利号:US-4473575-A
优先权日:1982-07-19
标 题 :3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
发明人：WATTHEY JEFFREY W H
权利人:CIBA GEIGY CORP
摘要:Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzaz epin-2-ones and functional derivatives are angiotensin converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.

专利号:US-2002183515-A1
优先权日:2001-05-18
标题 :Asymmetric synthesis of a key intermediate for making benazepril and analogues thereof