CAS: 94790-37-1; 1-(Bis(Dimethylamino)Methylene)-1H-Benzo[d][1,2,3]Triazole-1-Ium 3-Oxide Hexafluorophosphate(V)

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专利信息

专利号:WO-2024135609-A1
优先权日:2022-12-20
标 题:Linker for nucleic acid synthesis, carrier, and methods for producing same
发明人：HARI YOSHIYUKI; KAJINO Ryohei
权利人:SYNCREST INC
摘要:The purpose of the present invention is to newly provide a linker for nucleic acid synthesis and a carrier for solid-phase nucleic acid synthesis. Provided are a precursor to a linker for nucleic acid synthesis, a linker for nucleic acid synthesis, and a carrier for solid-phase nucleic acid synthesis.

专利号:US-12024537-B2
优先权日:2018-05-31
标题 :Compositions and methods for chemical synthesis
发明人：SEIFERT COLE
权利人:SEDERMA SA
摘要:The disclosure relates to chemical compositions that can include anchor molecules for chemical synthesis. GAP anchor molecules can include GAP constituents, linker constituents, and spacer constituents. Anchor molecules can be used to synthetically manufacture peptides. A novel method of solution-phase peptide synthesis is also disclosed that utilizes novel group-assisted purification protecting groups to facilitate efficient, scalable chemistry to synthetically manufacture peptides.

专利号:US-11472777-B2
优先权日:2015-09-14
标题:Piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction
发明人：SHOSHAN-BARMATZ VARDA; LEV GRUZMAN ARIE
权利人:NAT INST BIOTECHNOLOGY NEGEV LTD
摘要:Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's and Parkinson's diseases.

专利号:US-12173022-B2
优先权日:2019-03-29
标 题 :Method for producing RNA
发明人：MIYAGAWA TAKUYA; WAIZUMI NOBUAKI
权利人:SUMITOMO CHEMICAL CO
摘要:The present invention provides a method for preparing RNA by a phosphoramidite solid-phase synthesis using an porous inorganic carrier containing a primary amino group, the method being able to bring about an increased purity even in the synthesis of medium-stranded to long-stranded RNA. In the method for producing RNA, an amount of the primary amino group contained in the porous inorganic carrier satisfies the following formula (1): 0.7≤(I×R)/S≤1.8 [wherein, I is an amount of the amino group per unit mass of the porous inorganic carrier (μmol/g), as measured by a 2-nitrobenzenesulfonic acid adsorption method; R is a ratio of the primary amino group in the total amino groups contained in the porous inorganic carrier (amount of primary amino group/amount of total amino groups); and S is a specific surface area (m2/g) of the porous inorganic carrier as measured by a nitrogen adsorption method].

专利号:US-10508091-B2
优先权日:2015-09-14
标 题:Piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction
发明人：SHOSHAN-BARMATZ VARDA; LEV GRUZMAN ARIE
权利人:NAT INST BIOTECHNOLOGY NEGEV LTD
摘要:Provided herein piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction. Also provided methods of treatment of diseases associated with said processes, e.g. Alzheimer's disease.

专利号:US-8003785-B2
优先权日:2008-06-18
标 题 :Halo-substituted pyrimidodiazepines
发明人：CAI JIANPING; CHEN SHAOQING; CHU XIN-JIE; LUK KIN-CHUN; MISCHKE STEVEN GREGORY; SUN HONGMAO; WOVKULICH PETER MICHAEL
权利人:TAKEDA PHARMACEUTICAL
摘要:The present invention provides PLK1 inhibitor compounds of formula I: n nuseful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula I.