CAS: 99-88-7; 4-Isopropylaniline

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CAS号16152-51-5 4-异丙基苯硼酸 | CAS号1817-47-6 对硝基异丙基苯 | CAS号15887-26-0 Diazene,1,2-bis... | CAS号63693-65-2 4-异丙基苯肼 | CAS号98-82-8 异丙基苯 | CAS号74-98-6 丙烷 | CAS号920-39-8 异丙基溴化镁 | CAS号540-37-4 对碘苯胺 | CAS号2479-47-2 2,2-双(4-氨基苯基)丙烷 | CAS号34123-59-6 异丙隆 | CAS号31027-31-3 4-异丙基苯异氰酸酯 | CAS号150560-58-0 5-异丙基吲哚啉-2,3-二酮 | CAS号51605-97-1 2-溴-4-异丙基苯胺 | CAS号4132-48-3 4-异丙基苯甲醚 | CAS号252285-20-4 1-(4-propan-2-y... | CAS号100-00-5 对硝基氯苯 | CAS号99-89-8 4-异丙基苯酚 | CAS号89007-45-4 4-异丙基苯基硫代异氰酸酯 | CAS号63649-64-9 4-异丙基-2-硝基苯胺

1-氯-4-丙-2-基苯置于硫酸氢铵,Bis(1,5-Cyclooctadiene)Nickel (0),Sodium T-Butanolate体系中,化学反应 12.0H,以81%的收率获得产物4-异丙基苯胺
参考文献:带有笼状p,N连接位点的亚磷酸三嗪聚合物配体:镍催化的芳基氯和苯酚的胺化反应中的有效配体†
标题:带有笼状p,N连接位点的亚磷酸三嗪聚合物配体:镍催化的芳基氯和苯酚的胺化反应中的有效配体†
摘要:一种新型的p,N-配体被引入以有效地ni催化芳基氯化物的胺化.氰尿酸(1,3,5-三嗪-2,4,6-三醇)与三氯膦(pcl 3)导致了一种新的多孔材料(tppm)的生产,该材料包含片状形态的具有亚磷酸酯部分的三嗪环.制备的化合物中的空腔会在材料表面上形成具有适当连接特性的位点,以与金属配合用于催化目的.在这种容易制备且可重复使用的p,N-配体的存在下,镍催化的芳基氯化物和2,4,6-三芳氧基-1,3,5-三嗪(tat)保护型苯酚的胺化反应得以有效完成.在温和的反应条件下.更重要的是,Tppm在遵循此协议后可重复使用5次,而其活动没有明显减少.
DOI:10.1039/c6Ra14367A

专利信息

专利号:WO-9517903-A1
优先权日:1993-12-28
标 题:Modular design and synthesis of oxazolone-derived molecules
发明人：HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG
权利人:ARQULE PARTNERS L P; HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG
摘要:The design and synthesis of novel oxazolone-derived molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.

专利号:WO-9931124-A1
优先权日:1997-12-12
标 题:Cholic acid-based scaffolds for multidimensional molecular presentation of peptides
发明人：HOEEG-JENSEN THOMAS
权利人:NOVO NORDISK AS; HOEEG JENSEN THOMAS
摘要:A solid phase method for the synthesis of a plurality of differently substituted cholic acid scaffolds with a wide variety of peptide chain, pseudo-peptide chain or peptoid chain substitutents, as leads or compounds of potential therapeutic interest. The substituted cholic acids are prepared by initial solution synthesis of a scaffold holding amino acids with 3 orthogonal protecting groups. Subsequent solid-phase synthesis provides the build-up of the target molecules, either as discretes or in mixture. The molecules may be screened on the resin or cleaved from the resin and then screened in solution. The method disclosed here provides an easy and fast access to highly diverse compounds, potential peptide mimetics and potential leads for compounds of therapeutic interest. The method is amenable to automatization.

专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

专利号:WO-2024134682-A1
优先权日:2022-12-21
标题:(n-alkyldihydrol-2h-oxazinyl)-cannabidiol as anti-proliferative agent and process for preparation thereof
发明人：CHAM PANKAJ SINGH; SINGH AJEET; JAMWAL ASHIYA; SINGH RATTANDEEP; - SHABU; THAPA SONIA; WAZIR PRIYA; NANDI UTPAL; SINGH SHASHANK KUMAR; SINGH PARVINDER PAL
权利人:COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN OF S
摘要:The present invention relates to ring annulated analogues of cannabidiol where either one or both sides of the aromatic ring are attached to the oxazinyl ring, their method of preparation and use as anti-proliferative agents. The present invention provides a ring annulated cannabidiol analogue compound of Formula I. The present invention further provides a process for the synthesis of ring annulated cannabidiol analogue compound of Formula I.

专利号:US-6541653-B2
优先权日:2001-04-26
标题 :Synthesis of carbamate through low pressure heterogeneous oxidative carbonylation of amines
发明人：CHUANG STEVEN S C; CHI YAWU; CHEN BEI; TOOCHINDA PISANU
摘要:The process disclosed herein satisfies the need in the art for an industrially viable oxidative carbonylation catalytic system, and is capable of producing carbamates at a significantly higher rate than those processes reported in journal and patent literature. This reaction process takes place via a reaction mechanism that does not involve drastic conditions. Specifically, the catalytic system of the present invention employs Group VIII metal catalysts and/or copper-based catalysts with halide promoters to produce carbamates through heterogeneous oxidative carbonylation at atmospheric pressure and relatively non-drastic temperatures in a gas-solid carbonylation process.

专利号:US-7482492-B2
优先权日:2007-04-12
标 题 :Cost effective method for synthesis of triarylamine compounds
发明人：COGGAN JENNIFER A; HU NAN-XING
权利人:XEROX CORP
摘要:A process for forming a triarylamine compound includes reacting a halogenated aryl alcohol with an alcohol protecting agent and a first base to form a halogenated protected aryl alcohol compound, and reacting the halogenated protected aryl alcohol compound with an amine in the presence of a suitable catalyst and a second base.