CAS: 112970-44-2; 2-Bromo-3-Methoxyaniline

相似化合物

67853-37-6 35736-52-8 19056-40-7

上下游产品

2-溴-3-硝基苯甲醚 2-Bromo-1-Methoxy-3-Nitrobenzene 67853-37-6
间氨基苯甲醚 M-Anisidine 536-90-3
2-Bromo-N-Pivaloyl-3-Methoxyaniline 168335-61-3
(2-溴-3-甲氧基苯基)氨基甲酸叔丁酯 (2-Bromo-3-Methoxyphenyl)Carbamic Acid Tert-Butyl Ester 809231-02-5

N-(3-甲氧基苯基)-2,2-二甲基丙酰胺置于盐酸,正丁基锂体系中,用 四氢呋喃,1,4-二氧六环,正己烷 用作溶剂,化学反应 15.0H,反应生成2-溴-3-甲氧基苯胺
参考文献:(2,7-二取代-1,8-联苯二氧基)双(二甲基铝)作为双齿有机铝路易斯酸:双亲电活化现象的阐明和合成效用
标题:(2,7-二取代-1,8-联苯二氧基)双(二甲基铝)作为双齿有机铝路易斯酸:双亲电活化现象的阐明和合成效用
摘要:通过用 Me3Al 处理必需的 2,7-二取代-1,8-联苯二醇 (1),可以很容易地原位制备一系列 (2,7-二取代-1,8-联苯二氧基) 双(二甲基铝) (2) (2 当量)在室温下的 Ch2Cl2 中;这主要依赖于从廉价的间茴香胺开始成功建立 1 的新合成程序.与传统的单齿路易斯酸二甲基铝 2,6-二甲苯氧化物 (11) 相比,通过使用 Bu3Snh 作为氢化物源还原酮底物,对 2 作为双齿有机铝路易斯酸进行了评估,揭示了 2 的显着高活化能力向羰基.特别是,(2,7-二甲基-1,8-联苯二氧基)双(二甲基铝)(2A)发挥了最高的反应性,这在向山羟醛反应中也得到了强调.双齿路易斯酸 2 的结构通过对具有大体积 3,5-二叔丁基苯基取代基的 2G 的单晶 X 射线衍射分析明确确定,揭示了固态的刚性二聚体组装.2A 对羰基底物的双亲电活化得到了低温 13C NMR 分析以及使用 Gaussian
Doi:10.1021/ja030552S

专利信息

专利号:US-12384788-B2
优先权日:2019-09-13
标 题 :1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as LRRK2, NUAK1 and/or TYK2 kinase modulators for the treatment of e.g. autoimmune disease
发明人：KOESTLER ROLAND; TASSEL JEAN; THORMANN MICHAEL; YEHIA NASSER; TREML ANDREAS; ALMSTETTER MICHAEL
权利人:ORIGENIS GMBH
摘要:The present invention relates to compounds of formula (I) that are capable of modulating, e.g., inhibiting or activating, one or more kinases, especially LRRK2 and/or NUAK1 and/or TYK2 or mutants thereof. The compounds are useful for treating diseases, such as autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, Alzheimer's disease, Parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 40 to 146; examples 1 to 63; compounds 1 to 248; tables 1 to 3). Preferred compounds are e.g. 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds. An exemplary compound is e.g. 5-(2,6-difluorophenyl)-8-methoxy-1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine (example 49). (Formula (II):

专利号:US-9067934-B2
优先权日:2011-03-31
标题 :Bicyclic pyridinones
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; FISH BENJAMIN ADAM; GREEN MICHAEL ERIC; MULLINS PATRICK BRADLEY; STIFF CORY MICHAEL; TRAN TUAN PHONG; NAVARATNAM THAYALAN
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.