CAS: 133865-89-1; (S)-2-((4-((3-Fluorobenzyl)Oxy)Benzyl)Amino)Propanamide

上下游产品

4-(3-fluoro-benzyloxy)-benzaldehyde (S)-alaninamide hydr°Chloride L-alanine amide (S)-2-[4-(3-fluorobenzyloxy)benzylideneamino]propanamidesafinamide mesylate safinamide mesylate

N2-{4-[(3-Fluorobenzyl)Oxy]Benzyl}-N2-[(2-Nitrophenyl)Sulfonyl]-L-Alaninamide置于potassium Carbonate,苯硫酚体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 6.0H,以86%的收率获得沙芬酰胺
参考文献: An Improved Synthesis Of Anti-Parkinson Agent[fr] Synthèse Améliorée D'Agent Antiparkinsonien
标题: An Improved Synthesis Of Anti-Parkinson Agent[fr] Synthèse Améliorée D'Agent Antiparkinsonien
摘要:本发明涉及一种改进的合成抗帕金森化合物的方法,该化合物的化学式为(i),可从商业上可获得的(R)-苄基环氧乙烷合成,其中所得化合物的对映纯度大于98%.化学式(i)中,R1和r2各自独立地选自氢或卤素.

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-9475757-B2
优先权日:2013-05-03
标 题 :Synthesis of anti-Parkinson agent
发明人：MUTHUKRISHNAN MURUGAN; MUJAHID MOHAMMAD
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to an improved process for synthesis of anti-Parkinson compound of formula (I) from commercially available (R)-benzyl glycidyl ether, wherein the compound obtained has enantiopurity greater than >98%. Formula (I) wherein R 1 and R 2 are each independently selected from hydrogen or halogen.

专利号:US-11299455-B2
优先权日:2018-07-12
标 题:Process for diastereoselective synthesis of vicinal diamines
发明人：LELETI RAJENDER REDDY; KOTTURI SHARADSRIKAR; NALIVELA KUMARA SWAMY; PATEL CHIRAG; RAVAL POOJABAHEN; ZALAVADIYA VINKAL
权利人:PIRAMAL PHARMA LTD
摘要:The present invention relates to an improved process for diastereoselective synthesis of vicinal diamines (1). The process involves highly regio- and diastereoselective addition of 2-azaallyl anions (4) to N-tert-butanesulfinylimines (5) to produce vicinal diamines (1).

专利号:EP-4605403-A1
优先权日:2022-10-17
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.

专利号:US-11111208-B2
优先权日:2019-06-17
标题:Process for the preparation of safinamide mesylate intermediate
发明人：KOVI RAVISHANKER; KANNAPPAN JAYARAMAN; PATEL RAJESH A; PATEL DAXESHKUMAR PRAKASHBHAI
权利人:RK Pharma Solutions LLC
摘要:The present application provides methods for the synthesis of intermediates in the synthesis of Safinamide or a pharmaceutically acceptable salt thereof herein Safinamide Mesylate, that is substantially free of impurities.

专利号:US-2015158809-A9
优先权日:2013-02-26
标 题 :Method of making 1-(acyloxy)-alkyl carbamate compounds
发明人：WANG HUAN; LIU PENG; DAI QUNYING; YIN HAO; RAILLARD STEPHEN P
权利人:XENOPORT INC
摘要:Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.