CAS: 27144-18-9; 3-(Tritylthio)Propanoic Acid

上下游产品

CAS号76-83-5 三苯基氯甲烷 | CAS号107-96-0 3-巯基丙酸 | CAS号76-84-6 三苯基甲醇 | CAS号590-92-1 3-溴丙酸 | CAS号3695-77-0 三苯甲硫醇 | CAS号76-84-6 三苯基甲醇 | CAS号52574-08-0 3-(乙酰胺甲硫基)丙酸 | CAS号129431-12-5 1-[1-氧代-3-[(三苯基... | CAS号19303-32-3 1-methyl-1,3,3-... | CAS号519-73-3 三苯基甲烷

3-溴丙酸,三苯甲硫醇置于sodium Hydride体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 1.0H,以82%的收率获得3-(三苯甲硫基)丙酸
参考文献:人生长抑素受体特异性的骨架环类似物含有新型硫构建单元.
标题:人生长抑素受体特异性的骨架环类似物含有新型硫构建单元.
摘要:生长抑素14(somatostatin)及其临床可用的类似物奥曲肽,兰瑞肽和伐普肽是生长激素,胰岛素和胰高血糖素释放的有效抑制剂.最近,描述了一种具有体内内分泌选择性的新型骨干环生长抑素类似物c(gaba-Phe-Trp-(d)trp-Lys-Thr-Phe-Glyc3-Nh(2))(类似物1,Ptr 3173).这种长效八肽对人重组生长抑素受体(hsst)hsst2,Hsst4和hsst5具有高亲和力.其新颖的结合特性可有效抑制体内生长激素,但不能抑制胰岛素释放.我们报告了与1相关的化合物的合成,生物活性和构效关系研究.在这些类似物中,1的内酰胺桥被骨架二硫键取代.我们提出了一种新的方法,通过利用含硫的建筑单元对树脂骨架骨架化肽的构象约束.如在各种酶混合物中测试的,这些1的二硫键主链环状类似物显示出显着的代谢稳定性.受体结合测定揭示了与它们的原型相比,这些类似物的不同的受体选择性特征.发
Doi:10.1021/jm0100281

专利信息

专利号:US-8816050-B2
优先权日:2006-03-22
标题:Method of preparing glycopeptides
发明人：WONG CHI-HUEY; BRIK ASHRAF; YANG YU-YING; FICHT SIMON; PAYNE RICHARD
权利人:WONG CHI-HUEY; BRIK ASHRAF; YANG YU-YING; FICHT SIMON; PAYNE RICHARD; SCRIPPS RESEARCH INST
摘要:A method is provided for the synthesis of glycopeptides using a sugar assisted ligation strategy, wherein an N-terminal peptide portion in the form of a thioester is coopled with a C-terminal peptide portion bearing a carbohydrate moiety comprising a thiol group.

专利号:WO-2023179723-A1
优先权日:2022-03-25
标题:Cleavable fragment directed by affinity fragment, design and synthesis thereof, and use thereof in preparation of site-directed drug conjugate
发明人：HUANG WEI; TANG FENG; ZENG YUE
权利人:SHANGHAI INST MATERIA MEDICA CAS
摘要:Provided in the present invention are a cleavable fragment directed by an affinity fragment, the design and the synthesis thereof, and the use thereof in the preparation of a site-directed drug conjugate. Specifically, provided in the present invention is a conjugate with a ligand affinity directing group. The conjugate is as represented by formula I: AT-CL-R (I), wherein AT is an affinity moiety for a target protein (TP); CL is a cleavable fragment which has a self-cleaving reactivity; and R is a group to be modified to the target protein.

专利号:EP-1206494-B1
优先权日:1999-08-02
标 题:Computational design methods for making molecular mimetics
发明人：CASSET FLORENCE; GRANIER CLAUDE; KACZOREK MICHEL; LAHANA ROGER; REES ANTHONY; ROUX FLORENCE
权利人:SYNT EM SA
摘要:Methods are proposed for the design and synthesis of a molecule which mimics the activity of a parent molecule. In particular the methods relate to computationally identifying chemical groups of a parent molecule for inclusion in a mimetic, designing a mimetic taking into account the folding structure of the parent, designing a mimetic using a relative geometrical relationship of chemical groups in the parent molecule, designing a mimetic using a molecular dynamics simulation of the mimetic, and screening potential mimetics using molecular dynamics simulation.

专利号:US-8349899-B1
优先权日:2008-12-03
标题:Selective inhibitors of EG5 motors and methods of use
发明人：ARTERBURN JEFFREY; SHUSTER CHARLES
权利人:ARROWHEAD CT INC; ARTERBURN JEFFREY; SHUSTER CHARLES
摘要:Embodiments of the present invention comprises a compound of formula I or its enantiomer, diastereomer, stereoisomer or its pharmaceutically acceptable salt, methods of use and methods of synthesis.

专利号:US-9073978-B2
优先权日:2011-03-10
标 题:Method for producing glycopeptide having sialyl sugar chain, sialyl sugar chain-added amino acid derivative to be used in same, and glycopeptide
发明人：KAJIHARA YASUHIRO; MURAKAMI MASUMI; ISHII KAZUYUKI
权利人:KAJIHARA YASUHIRO; MURAKAMI MASUMI; ISHII KAZUYUKI; GLYTECH INC
摘要:[Technical Problem] n To provide a method for manufacturing that enables to obtain a targeted glycopeptide harboring a sialyl sugar chain in high yield without decomposing sialic acid at a non-reducing terminal of sugar chain when the glycopeptide is synthesized by a Boc solid phase synthesis method. n [Solution to Problem] n The present invention is characterized in that the Boc-sialylglycosylated amino acid derivative used in Boc solid phase synthesis method is one where the carboxyl group of the sialic acid at the sugar chain non-reducing terminal is protected with a phenacyl group.

专利号:CN-107903389-B
优先权日:2017-12-19
标题:Synthesis and application of E-selectin-targeted polyethylene glycol two-end double-modified antitumor drug