CAS: 32857-62-8; 4-(Trifluoromethyl)Phenylacetic Acid

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CAS号124-38-9 二氧化碳 | CAS号939-99-1 4-(三氟甲基)苄基氯 | CAS号512787-33-6 1-(pyrrolidin-1... | CAS号1436389-36-4 2-[4-(carboxyme... | CAS号135325-18-7 2-(4-(三氟甲基)苯基)乙酸甲酯 | CAS号1798-06-7 4-碘苯乙酸 | CAS号1436389-45-5 methyl 2,2-difl... | CAS号2338-75-2 4-(三氟甲基)苯乙腈 | CAS号52787-14-1 4-甲酸甲酯苯乙酸甲酯 | CAS号455-19-6 对三氟甲基苯甲醛 | CAS号721-63-1 4-(三氟甲基)苯乙酸乙酯 | CAS号6140-17-6 4-甲基三氟甲苯 | CAS号1407166-67-9 3-hydroxy-2-iso... | CAS号102422-55-9 4-(三氟甲基L)苄基异氰酸酯 | CAS号35315-48-1 3-(2-aminopheny... | CAS号35318-44-6 3-(2-nitropheny... | CAS号30934-62-4 4-三氟甲基苯乙醛 | CAS号130365-87-6 4-(三氟甲基)苯乙基溴

N,N-Dimethyl-4-(Trifluoromethyl)Benzylamine置于(4,4'-二叔丁基-2,2'-联吡啶)双[(2-吡啶基)苯基]铱(Iii)六氟磷酸盐,Sodium Carbonate,Caesium Carbonate体系中,用 乙醚,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 26.0H,反应生成 4-三氟甲基苯乙酸
参考文献:四烷基铵盐的可见光驱动的无外部还原剂交叉电偶偶联
标题:四烷基铵盐的可见光驱动的无外部还原剂交叉电偶偶联
摘要:两个亲电子试剂之间的交叉亲电子试剂偶联是在化学计量外部还原剂存在下反应生成 Cc 键的有效且经济的方法.在此,我们报告了一种通过可见光光氧化还原催化实现第一个无外部还原剂的交叉亲电子偶联的新策略.各种带有伯,仲和叔 Cn 键的四烷基铵盐与醛/酮和 Co2 进行选择性偶联.值得注意的是,原位反应生成的副产物三甲胺被有效地用作电子供体.此外,该协议表现出温和的反应条件,低催化剂负载,广泛的底物范围,非常好的官能团耐受性和容易的可扩展性.机理研究表明,苄基自由基和阴离子可能是通过光催化产生的关键中间体,
DOI:10.1021/jacs.8B08792

专利信息

专利号:US-2021107859-A1
优先权日:2018-04-06
标题 :A process for the synthesis of carbon labeled organic compounds
发明人：AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-9409879-B2
优先权日:2011-03-29
标 题 :Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents
发明人：DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA
权利人:DAVIOUD-CHARVET ELISABETH; LANFRANCHI DON ANTOINE; JOHANN LAURE; WILLIAMS DAVID LEE; CESAR RODO ELENA; CENTRE NAT RECH SCIENT
摘要:Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.

专利号:US-6177572-B1
优先权日:1997-08-20
标题 :Solid and liquid-phase synthesis of benzoxazoles and benzothiazoles and their use
发明人：WANG FENGJIANG
权利人:SEPRACOR INC
摘要:Methods for preparing benzoxazoles and benzothiazoles on solid supports. Substituted benzothiazoles and benzoxazoles, libraries of the compounds, and methods of using the compounds are also disclosed.

专利号:WO-2024054881-A1
优先权日:2022-09-07
标题:Ligand-enabled scalable c-h hydroxylation of benzoic and phenylacetic acids at room temperature
发明人：YU JIN-QUAN; LI ZHEN; PARK HAN
权利人:SCRIPPS RESEARCH INST
摘要:The application discloses industry scalable methods of using bifunctional bidentate pyridone-carboxylic acid ligands, such as 2-methyl-2-(6-oxo-1,6-dihydropyridin-2-yl)propanoic acid, that enable room-temperature Pd-catalyzed C-H hydroxylation of a broad range of benzoic and phenylacetic acids with an industry-compatible oxidant, aqueous hydrogen peroxide, at room temperature. Further disclosed are methods of derivatization of the resulting hydroxylation products, synthesis of polyfluorinated natural products coumestan or pterocarpene from phenol building blocks, and hydroxylation of ibuprofen using this methodology,

专利号:US-4426536-A
优先权日:1982-06-14
标 题:Synthesis of phenylacetic acid esters
发明人：ROBEY ROGER L
权利人:LILLY CO ELI
摘要:Esters of phenylacetic acids are prepared in a single step by hydrolysis of 2,2,2-trichloro-1-phenylethanes in inorganic basic media.