CAS: 343306-79-6; 6-Per-Deoxy-6-Per-(2-Carboxyethyl)Thio-γ-Cyclodextrin Sodium Salt

以43的收率获得octasodium;3-[[(1S,3S,5S,6S,8S,10S,11S,13S,15S,16S,18S,20S,21S,23S,25S,26S,28S,30S,31S,33S,35S,36S,38S,40S,41R,42R,43R,44R,45R,46R,47R,48R,49R,50R,51R,52R,53R,54R,55R,56R)-10,15,20,25,30,35,40-Heptakis(2-Carboxylatoethylsulfanylmethyl)-41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56-Hexadecahydroxy-2,4,7,9,12,14,17,19,22,24,27,29,32,34,37,39-Hexadecaoxanonacyclo[36.2.2.23,6.28,11.213,16.218,21.223,26.228,31.233,36]Hexapentacontan-5-Yl]Methylsulfanyl]Propanoate
参考文献:6-Mercapto-Cyclodextrin Derivatives:Reversal Agents For Drug-Induced Neuromuscular Blok
标题:6-Mercapto-Cyclodextrin Derivatives:Reversal Agents For Drug-Induced Neuromuscular Blok
摘要:本发明公开了一种具有通式(I)的6-巯基环糊精衍生物,其中m为0-7,N为1-8,且m+n=7或8;R为(C1-6)烷基,可选地取代1-3个羟基,或(Ch2)O-苯基-(Ch2)P-;O和p独立地为0-4;X为cooh,Conhr1,Nhcor2,So2Oh,Po(Oh)2,O(Ch2-Ch2-O)Q-H,Oh或四唑-5-基;R1为h或(C1-3)烷基;R2为羧基苯基;Q为1-3;或其药学上可接受的盐.该6-巯基环糊精衍生物非常适用于逆转药物诱导的神经肌肉阻滞.

专利信息

专利号:US-9120876-B2
优先权日:2010-08-25
标 题 :Process for preparation of Sugammadex
发明人：DAVULURI RAMAMOHAN RAO; PONNAIAH RAVI; SRIBHASHYAM RAVI KANTH; VALSAN NANDKUMAR MECHERILI; DONGARI NARESH; CHLNV PRASAD; BATTHINI GURUSWAMY
权利人:DAVULURI RAMAMOHAN RAO; PONNAIAH RAVI; SRIBHASHYAM RAVI KANTH; VALSAN NANDKUMAR MECHERILI; DONGARI NARESH; CHLNV PRASAD; BATTHINI GURUSWAMY
摘要:A novel process for the preparation of 6-perdeoxy-6-per-halo Gamma cyclodextrin which is a useful intermediate in the synthesis of Sugammadex is disclosed in the invention. The process involves reacting Gamma cyclodextrin with phosphorous halide in the presence of organic solvent.

专利号:ES-2948930-T3
优先权日:2017-11-27
标题 :Process for the synthesis of a cyclodextrin derivative

专利号:JP-7460521-B2
优先权日:2017-11-27
标题:Method for the synthesis of cyclodextrin derivatives

专利号:US-2020377621-A1
优先权日:2017-11-27
标题 :Process for the synthesis of a cyclodextrin derivative

专利号:CN-111320712-A
优先权日:2020-04-09
标 题 :Synthesis method of sugammadex sodium intramolecular thioether impurity

专利号:CN-111471121-A
优先权日:2020-04-10
标题 :Synthesis method of sugammadex dimer impurity