CAS: 34967-24-3; 3,5-Dimethoxybenzyl Amine

该化合物是一种有机化合物,其特征是苯基胺结构,在3和5个位置上以两种甲氧基组取代苯环,这种化合物一般是无色的,可粉黄黄色液体或固体,视其形态和纯度而定,在有机溶剂中可溶解,并由于有矿物质功能组的存在而表现出中等极性; 甲氧组增强了其电子施食特性,可影响其反应和与其他化学物种的相互作用. 3-5-Dimethoxybenzylamine可以用于各种用途,包括有机合成的中间体,特别是制药和农用化学产品的生产. 其地雷功能允许其参与核分裂性反应,而甲氧基化合物组可影响其消毒性和电子特性,使其在合成化学中成为多用途化合物.处理和储存时,应参考安全数据,如任何化学物质一样.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

3,5-dimethoxybenzamide 3,5-dimethoxy-benzonitrile 3-carbamoyl-1,5-dimethoxy-1,4-cyclohexanediene 3,5-dimethoxybenzaldoxime 3-(aminomethyl)-1,5-dimethoxy-1,4-cyclohexadiene 2-chloro-N-(3,5-dimethoxybenzyl)acetamide 3,5-dihydroxybenzylamine 3',5'-Dimethoxy-2-iod-5-nitrodibenzylamin

合成工艺路线路线简述

  • 合成目标产物 3,5-Dimethoxybenzylamine 主要起始原料 5-Chloro-1,3-Dimethoxybenzene
  • (文献来源)合成步骤主要原料 5-Chloro-1,3-Dimethoxybenzene
3,5-二甲氧基苯甲醛置于氨,氢气体系中,用 甲醇 用作溶剂,100.0 °C,2.0 Mpa 条件下,反应 4.0H,以90%的收率获得3,5-二甲氧基苄胺
参考文献:石墨烯共壳钴纳米粒子选择性催化糠醛还原胺化为糠胺
标题:石墨烯共壳钴纳米粒子选择性催化糠醛还原胺化为糠胺
摘要:具有官能团的胺广泛用于制造药物,农用化学品和聚合物,但其中大部分仍通过石化路线制备.因此,从可再生资源(例如生物质)中可持续生产胺是必要的.为此,我们开发了一种环保,简化且高效的方法来制备基于地球丰富金属的无毒多相催化剂,该催化剂对糠醛或其他衍生物(超过 24示例)被证明是广泛可用的.更令人惊讶的是,钴负载的催化剂被发现可磁性回收且可重复使用多达 8 次,并具有出色的催化活性;另一方面,由相同催化剂催化的克级测试显示,与其较小规模相比,目标产品的收率相似,这与商业贵基催化剂相当.一系列分析技术的进一步结果,包括 Xrd,Xps,Tem/mapping 和原位ftir 表明催化剂的结构特征与其催化机制密切相关.简而言之,外部石墨壳被电子相互作用以及感应电荷重新分布激活,即使在非常温和的工业可行和可扩展的条件下,也可以轻松地将-nh 2部分替换为功能化和结构多样的分子.总体而言,这种新开发的
Doi:10.1039/d1Gc03578A

海关参考信息

专利信息


专利号:WO-0140193-A1
优先权日:1999-12-03
标题:Method for the synthesis of pyrazolines
发明人:BOLDI ARMEN M
权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.

专利号:US-2002103381-A1
优先权日:2000-11-30
标 题 :Method for the synthesis of pyrazolines
发明人:BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula I: n n n Also claimed are novel intermediates and their methods of synthesis.

专利号:US-10266565-B2
优先权日:2011-04-12
标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

专利号:WO-9931124-A1
优先权日:1997-12-12
标 题:Cholic acid-based scaffolds for multidimensional molecular presentation of peptides
发明人:HOEEG-JENSEN THOMAS
权利人:NOVO NORDISK AS; HOEEG JENSEN THOMAS
摘要:A solid phase method for the synthesis of a plurality of differently substituted cholic acid scaffolds with a wide variety of peptide chain, pseudo-peptide chain or peptoid chain substitutents, as leads or compounds of potential therapeutic interest. The substituted cholic acids are prepared by initial solution synthesis of a scaffold holding amino acids with 3 orthogonal protecting groups. Subsequent solid-phase synthesis provides the build-up of the target molecules, either as discretes or in mixture. The molecules may be screened on the resin or cleaved from the resin and then screened in solution. The method disclosed here provides an easy and fast access to highly diverse compounds, potential peptide mimetics and potential leads for compounds of therapeutic interest. The method is amenable to automatization.

专利号:US-10188136-B2
优先权日:2016-02-16
标题:Hydrophobin mimics: process for preparation thereof
发明人:BRITTO Sandanaraj Selvaraj; REDDY Mullapudi Mohan; BHANDARI PAVANKUMAR JANARDHAN; RAO KASULADEVU JAGANNADHA
权利人:INDIAN INSTITUTE OF SCIENCE EDUCATION AND RES
摘要:The present invention discloses hydrophobin mimics of formula (I) comprising a protein head group, hydrophilic linker and hydrophobic tail and to a process for synthesis of library of hydrophobin mimics thereof. The hydrophobin mimics of the present invention self-assemble to form protein nanoparticles/nanocontainer either alone or in a specified chemical environment. The hydrophobin mimics (I) of the present invention find application in area of bio-nanotechnology.

专利号:US-2003092064-A1
优先权日:2001-04-05
标题 :System for the synthesis of spatially separated libraries of compounds and methods for the use thereof
发明人:READER JOHN C
权利人:MILLENNIUM PHARM INC
摘要:Featured is an apparatus useful for preparing combinatorial libraries of compounds in a parallel fashion so that the individual compounds of the library are spatially separate and the position of each compound of the library in the apparatus is known. Moreover, the apparatus is useful for the preparation of combinatorial libraries of compounds where the library is constructed from three or more building blocks, e.g., three, four, five, six or seven building blocks, resulting in a three, four, five, six or seven dimensional combinatorial library. Also featured are related methods for the preparation of three, four, five, six or seven dimensional combinatorial libraries of compounds using the apparatus of the present invention.
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主要参考文献

[参考文献]: Jishan Wu, Et Al. Efficient Production Of [n]Rotaxanes By Using Template-Directed Clipping Reactions. Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17266-71.

合成参考文献


摘要:Khartulyari, A.; Maier, M. E., Science of Synthesis Knowledge Updates, (2010) 3, 97.
摘要:Pilgrim, B. S.; Tucker, M. J., Science of Synthesis Knowledge Updates, (2019) 1, 201.
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