CAS: 498-23-7; 2-Methylmaleic Acid

该化合物是一种二恶英酸,其独特结构具有二恶英的特征,其中包括其链条中第二和第三碳原子之间的双联结,这种不饱和性能有助于其反应和在有机合成中的潜在应用.它看起来像是白色晶体固体,在水中可溶解,在各种化学过程中有用. 铬酸以其进行聚合的能力而著称,导致形成多聚(硅酸),它有可能应用于生物降解材料的生产.此外,它可以作为合成其他化合物的前体,包括药物和农用化学品.化合物展示典型的酸特性,包括溶液中捐献质子的能力,其衍生物可用于各种化学反应,例如酯化和恐吓.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

itaconic acid anhydride 3-methylhexa-2,4 dienedioic acid 2-Methoxy-4-methylphenol 2-methoxy-6-methyl-1,4-benzoquinonecitraconic acid dimethyl ester Mesaconic acid diethyl citraconate -2-methyl-3-(4-chlorophenyl)prop-2-enoic acid-2-methyl-3-(4-chlorophenyl)prop-2-enoic acid

合成工艺路线路线简述

    乌头酸置于水体系中,化学反应生成 柠康酸
    参考文献:Swarts,Jahresbericht Ueber Die Fortschritte Der Chemie Und Verwandter Theile Anderer Wissenschaften,1873,P. 579
    标题:Swarts,Jahresbericht Ueber Die Fortschritte Der Chemie Und Verwandter Theile Anderer Wissenschaften,1873,P. 579

    海关参考信息

    专利信息


    专利号:US-9643915-B2
    优先权日:2013-03-15
    标题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
    发明人:ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
    权利人:CERENIS THERAPEUTICS HOLDING SA
    摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

    专利号:US-9708354-B2
    优先权日:2013-03-15
    标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
    发明人:ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
    权利人:CERENIS THERAPEUTICS HOLDING SA
    摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

    专利号:WO-2004011474-A1
    优先权日:2002-07-31
    标题:Universal support media for synthesis of oligomeric compounds
    发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
    权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
    摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

    专利号:US-6653468-B1
    优先权日:2002-07-31
    标 题 :Universal support media for synthesis of oligomeric compounds
    发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH
    权利人:ISIS PHARMACEUTICALS INC
    摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

    专利号:WO-2017033128-A1
    优先权日:2015-08-25
    标题 :Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors
    发明人:HOOK DAVID; KU JIE; ZHOU JIANGUANG
    权利人:NOVARTIS AG; HOOK DAVID; KU JIE; ZHOU JIANGUANG
    摘要:The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors and prodrugs thereof.

    专利号:US-8198465-B2
    优先权日:2005-10-17
    标 题 :3-alkyl-5- (4-alkyl-5-oxo-tetrahydrofutran-2-yl) pyrrolidin-2-one derivatives as intermediates in the synthesis of renin inhibitors
    发明人:SEDELMEIER GOTTFRIED; GRIMLER DOMINIQUE; ACEMOGLU MURAT
    权利人:SEDELMEIER GOTTFRIED; GRIMLER DOMINIQUE; ACEMOGLU MURAT; NOVARTIS AG
    摘要:The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula II, n nor a salt thereof, and a compound of formula VIn n nor a salt thereof, wherein R 3 and R 4 as well as Act are as defined in the specification, and processes of manufacturing these.n n Additionally transformation of compounds (VI) with metallo organic compounds (VII) give rise to the new compounds (VIII) which are direct precursors for the preparation of Aliskiren.
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    主要参考文献


    1: Pulat M, Akalın GO, Karahan ND. Lipase release through semi-interpenetrating polymer network hydrogels based on chitosan, acrylamide, and citraconic acid. Artif Cells Nanomed Biotechnol. 2014 Apr;42(2):121-7. doi: 10.3109/21691401.2013.794356. Epub 2013 May 13. doi: 10.1523/JNEUROSCI.0426-16.2016.
    5: Haarmann A, Nehen M, Deiß A, Buttmann M. Fumaric Acid Esters Do Not Reduce Inflammatory NF-κB/p65 Nuclear Translocation, ICAM-1 Expression and T-Cell Adhesiveness of Human Brain Microvascular Endothelial Cells. Int J Mol Sci. 2015 Aug 13;16(8):19086-95. doi: 10.3390/ijms160819086.
    6: Cao J, Su T, Zhang L, Liu R, Wang G, He B, Gu Z. Polymeric micelles with citraconic amide as pH-sensitive bond in backbone for anticancer drug delivery. Int J Pharm. 2014 Aug 25;471(1-2):28-36. doi: 10.1016/j.ijpharm.2014.05.010. Epub 2014 May 13. doi: 10.1016/j.carbpol.2014.12.028. Epub 2014 Dec 31. French. doi: 10.1111/bph.13184. Epub 2015 Jun 12.

    合成参考文献


    摘要:Tsukamoto, M.; Kitamura, M., Science of Synthesis, (2009) 48, 352.
    摘要:Nguyen, B. N.; Hii, K. K.; Szymański, W.; Janssen, D. B., Science of Synthesis: Stereoselective Synthesis, (2011) 1, 664.
    摘要:Faber, K.; Hall, M., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 220.
    摘要:Shi, Y.; Cole-Hamilton, D. J.; Kamer, P. C. J., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 2, 211.
    摘要:Food and Cosmetics Toxicology., 2(327), 1964
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