专利号:US-7109377-B2 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products 发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R 权利人:HARVARD COLLEGE 摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.
专利号:WO-0006525-A9 优先权日:1998-07-25 标题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
专利号:WO-0006525-A2 优先权日:1998-07-25 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
专利号:US-10053423-B2 优先权日:2014-01-03 标 题:Radioiodinated compounds 发明人:DIMAGNO STEPHEN; HU BAO 权利人:NUTECH VENTURES 摘要:This disclosure relates to reagents and methods useful in the synthesis of aryl iodines, for example, in the preparation of iodine labeled radiotracers. The reagents and methods provided herein may be used to access a broad range of compounds, including aromatic compounds, heteroaromatic compounds, amino acids, nucleotides, and synthetic compounds.
专利号:US-8198432-B2 优先权日:2005-02-25 标题:Porphyrin-based compounds for tumor imaging and photodynamic therapy 发明人:PANDEY RAVINDRA K; SAJJAD MUNAWWAR; PANDEY SURESH; GRYSHUK AMY; OSEROFF ALLAN; PINCUS LEGAL REPRESENTATIVE STEPHANIE; NABI HANI A 权利人:PANDEY RAVINDRA K; SAJJAD MUNAWWAR; PANDEY SURESH; GRYSHUK AMY; OSEROFF ALLAN; PINCUS LEGAL REPRESENTATIVE STEPHANIE; NABI HANI A; HEALTH RESEARCH INC; RES FOUNDATION SUNY 摘要:This invention describes a first report on the synthesis of certain 124 I-labelled photosensitizers related to chlorines and bacteriochlorins with long wavelength absorption in the range of 660-800 nm. In preliminary studies, these compounds show a great potential for tumor detection by positron emission tomography (PET) and treatment by photodynamic therapy (PDT). The development of tumor imaging or improved photodynamic therapy agent(s) itself represent an important step, but a dual function agent (PET imaging and PDT) provides the potential for diagnostic body scan followed by targeted therapy.
专利号:US-6448443-B1 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
[参考文献]: Beatrice Felber, Et Al. Dendritic Metalloporphyrins With A Distal H-Bond Donor As Mimics Of Haemoglobin. Org Biomol Chem. 2003 Apr 7;1(7):1090-3. [参考文献]: G Vaidyanathan, Et Al. Radiolabeled Guanine Derivatives For The In Vivo Mapping Of O(6)-Alkylguanine-Dna Alkyltransferase: 6-(4-[(18)F]Fluoro-Benzyloxy)-9H-Purin-2-Ylamine And 6-(3-[(131)I]Iodo-Benzyloxy)-9H-Purin-2-Ylamine. Bioconjug Chem. 2000 Nov-Dec;11(6):868-75.
合成参考文献
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