CAS: 64544-07-6; 1-Acetoxyethyl (6R,7R)-3-((Carbamoyloxy)Methyl)-7-((Z)-2-(Furan-2-yl)-2-(Methoxyimino)Acetamido)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate

上下游产品

CAS号40258-78-4 1-溴乙基乙酸酯 | CAS号55268-75-2 头孢呋肟 | CAS号97232-96-7 5-Thia-1-azabic...

(E)-头孢呋辛酯 以 甲醇,水 作为反应溶剂,化学反应生成 头孢呋辛酯
参考文献:头孢呋辛酯及相关化合物的光异构化动力学
标题:头孢呋辛酯及相关化合物的光异构化动力学
摘要:用HPLC研究了头孢呋辛酯水溶液在254 Nm下的光致异构化动力学.总体降解是烷氧基亚氨基基团的异构化与β-内酰胺环的光解之间竞争的结果.头孢呋辛酯以两种非对映异构体的混合物形式存在,并显示出不同的反应速率.这不仅适用于光异构化步骤,而且适用于碱性条件下的基态水解.头孢呋辛酯的抗异构体及其某些降解产物也观测到了烷氧基亚氨基的光异构化.所有这些光异构化的量子产率始终低于1%,这说明了光解步骤的相对重要性.头孢呋辛酯的固定顺式与反比为1,头孢呋辛为2.1.从这项研究和以前的研究来看,与其他带有烷氧基亚氨基的抗生素相比,头孢呋辛酯在254 Nm照射下最敏感.氨曲南最稳定,其次是头孢噻肟,头孢呋辛和头孢呋辛酯.
DOI:10.1002/jps.2600830422

专利信息

专利号:US-6642378-B1
优先权日:1999-07-27
标题:Process for the synthesis of beta-lactam derivatives
发明人：CABRI WALTER; SIVIERO ENRICO; DAVERIO PAOLA LUIGIA; CRISTIANO TANIA; FELISI CLAUDIO; LONGONI DAVIDE
权利人:ANTIBIOTICOS SPA
摘要:The invention is directed towards a process for the preparation of Cefuroxime acid or for a corresponding pharmaceutically acceptable salt or ester. The process comprises the carbamoylation of a Cefuroxime precursor with an activated isocyanate. Additionally, the process is characterized by the fact that a carbonic C1-C4 alkyl ester is used as a solvent for the carbamoylation reaction.

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:WO-2009056955-A1
优先权日:2007-10-30
标题 :Amine-bearing phospholipids (abps), their synthesis and use
发明人：ZUMBUEHL ANDREAS
权利人:UNIV BASEL; ZUMBUEHL ANDREAS
摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

专利号:US-9907753-B2
优先权日:2010-03-19
标 题 :Lipid vesicle compositions and methods of use
发明人：IRVINE DARRELL J; MOON JAEHYUN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

专利号:EP-1196420-B1
优先权日:1999-07-27
标 题:A process for the synthesis of beta-lactam derivatives

专利号:EP-1196420-A1
优先权日:1999-07-27
标 题:A process for the synthesis of beta-lactam derivatives