CAS: 89766-91-6; 2-(Aminooxy)-2-Methylpropanoic Acid Hydrochloride

相似化合物

1785364-49-9 2059987-31-2 1252016-17-3

2-Benzoylaminooxy-2-Methyl-Propionic Acid置于盐酸体系中,用 水,溶剂黄146 作为反应溶剂,化学反应 6.0H,以93%的收率获得产物1-羧基-1-甲基乙氧基氯化铵
参考文献:未活化烯烃的无过渡金属的三组分自由基1,2-酰胺基烷基化
标题:未活化烯烃的无过渡金属的三组分自由基1,2-酰胺基烷基化
摘要:给出了未活化烯烃的过渡金属自由基1,2-酰胺基炔化反应.α-酰胺基氧基酸用作酰胺基自由基前体,它们被有机光氧化还原催化剂(4Czlpn)氧化.亲电性n自由基与各种脂肪族烯烃发生化学选择性反应,然后加成基被乙炔基苯并恶唑啉酮(ebx)试剂捕获,最终提供了酰胺基烷基化产物.这些在实际温和条件下进行的转化显示出较高的官能团耐受性和广泛的底物范围.机理研究支持了这些级联的激进性质.
DOI:10.1002/chem.201805490

专利信息

专利号:US-2011280803-A1
优先权日:2009-01-29
标 题 :Radioiodination method
发明人：AVORY MICHELLE; BROWN JANE; IVESON PETER BRIAN
权利人:AVORY MICHELLE; BROWN JANE; IVESON PETER BRIAN; GE HEALTHCARE UK LTD
摘要:The present invention provides a method for the synthesis of radioiodinated compounds which is advantageous over prior art methods. Using a hydrazine or an aminoxy in place of a primary amine for indirect radioiodination facilitates a much quicker reaction thus reducing reaction time and increasing the yield. In addition, where there are primary amines in the molecule to be radioiodinated, such as the N-terminus of a peptide or lysine residues, reaction at the hydrazine or aminoxy is greatly favoured.