CAS: 1341-23-7; 3-Carbamoyl-1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)Pyridin-1-Ium

相似化合物

23111-00-4 17720-18-2 1094-61-7

上下游产品

CAS号98-92-0 烟酰胺 | CAS号13035-61-5 四乙酰核糖 | CAS号98-92-0 烟酰胺

β-烟酰胺腺嘌呤二核苷酸置于水,Calcium Ascorbate,氯化锆(Iv)体系中,化学反应 48.5H,反应生成烟酰胺核糖
参考文献: Process For Preparation Of Nicotinamide Riboside (Nr) And Cosmetic Composition Comprising (Nr And A Phosphate-Binding Agent[fr] Procédé De Préparation De Nicotinamide Riboside (Nr) Et Composition Cosmétique Comprenant Du Nr Et Un Agent De Liaison De Phosphate
标题: Process For Preparation Of Nicotinamide Riboside (Nr) And Cosmetic Composition Comprising (Nr And A Phosphate-Binding Agent[fr] Procédé De Préparation De Nicotinamide Riboside (Nr) Et Composition Cosmétique Comprenant Du Nr Et Un Agent De Liaison De Phosphate
摘要:本文披露了一种从nr前体和磷酸盐结合剂在溶剂中制备烟酰胺核糖苷(nr)的过程.包含nr的反应产物混合物可以直接用于各种产品,特别是化妆品产品,无需进一步处理.

专利信息

专利号:WO-2023166160-A1
优先权日:2022-03-04
标 题:Process for synthesis of 1,4-dihydronicotinamide riboside (nrh) from nicotinamide-beta-riboside triacetate chloride (nra-cl)
发明人：MALKANNAGARI RAMANI; GUNDAPUNENI RAGHAVA RAO; BOHAN FRODE
权利人:BOHAN & CO AS
摘要:The present invention disclose novel process for synthesis of 1,4- dihydronicotinamide riboside (NRH). More particularly, the invention discloses a cost-effective synthesis of 1, 4-dihydronicotinamide riboside (NRH) from Nicotinamide-beta-riboside triacetate chloride (NRA-CI) in good yields and purity comprising the steps of a) reducing Nicotinamide-beta-riboside triacetate chloride (NRA-CI) in presence of non-chlorinated aprotic organic solvent and a reducing agent to obtain 1,4-dihydronicotinamide riboside triacetate (NRH-A); and b) deacetylating the 1,4-dihydronicotinamide riboside triacetate (NRHA) in presence of a base to obtain 1,4-dihydronicotinamide riboside(NRH)

专利号:US-2024247022-A1
优先权日:2021-05-04
标 题 :A Process for Synthesis of Nicotinamide Riboside Chloride (NRCL)
发明人：MALKANNAGARI RAMANI; GUNDAPUNENI RAGHAVA RAO; BOHAN FRODE
权利人:BOHAN & CO AS
摘要:The present invention discloses synthesis of nicotinamide riboside chloride (NRCI). More particularly, the present invention describes cost effective and industrially scalable process for the synthesis of NRCI in amorphous form.

专利号:US-8580949-B2
优先权日:2009-07-27
标题:Enzymatic synthesis of carba-NAD
发明人：DUEFEL HARTMUT; HEINDL DIETER; HORN CARINA; MEIER THOMAS; SCHMUCK RAINER
权利人:DUEFEL HARTMUT; HEINDL DIETER; HORN CARINA; MEIER THOMAS; SCHMUCK RAINER; ROCHE DIAGNOSTICS OPERATIONS
摘要:The disclosure concerns the enzymatic synthesis of stable analogues of nicotinamide adenine dinucleotide NAD/NADH and nicotinamide adenine dinucleotide phosphate NADP/NADPH, the so-called “carba-NADsâ€?, i.e. analogues of NAD/NADH or NADP/NADPH, respectively, comprising a carbacyclic sugar instead of ribose.

专利号:US-2021246476-A1
优先权日:2020-01-31
标 题:Biosynthesis of preparing nicotinamide mononucleotide and derivatives thereof
发明人：ZHANG YI HENG PERCIVAL
权利人:ZHANG YI HENG PERCIVAL
摘要:A method of making nicotinamide mononucleotide (NMN), nicotinamide mononucleotide derivatives, or mixtures thereof is disclosed. The method involves the in vitro artificial enzymatic pathways comprised: the generation of alpha-D-ribose-1-phosphate from numerous substrates followed by the synthesis of nicotinamide mononucleotide catalyzed by nicotinamide riboside phosphorylase and nicotinamide riboside kinase or the generation of 5-phospho-alpha-D-ribose-1-diphosphate from nucleotides followed by the synthesis of nicotinamide mononucleotide catalyzed by nicotinamide phosphoribosyltransferase. The multiple enzymes were reconstituted in one pot, wherein in-situ removal of byproducts that can be converted to other non-inhibitory chemicals with supplementary enzymes push the overall biotransformation toward the synthesis of nicotinamide mononucleotide. Furthermore, nicotinamide mononucleotide can be converted to its derivatives—nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate.

专利号:WO-2022094916-A1
优先权日:2020-11-06
标题:Method for improving activity of nicotinamide phosphoribosyltransferase, and composition thereof
发明人：YANG LIANG; LI XIANG
权利人:SHENZHEN INST OF ADV TECH CAS
摘要:A method for improving the activity of nicotinamide phosphoribosyltransferase, and a composition thereof. The method and composition are capable of increasing the deacetylation level of nicotinamide phosphoribosyltransferase (NAMPT) via a silent information regulator 2 related enzyme 1 (SIRT1), thus causing increased NAMPT activity, and further improving β-nicotinamide mononucleotide (β-NMN) and NAD+ levels. The composition is processed to improve the nicotinamide phosphoribosyltransferase activity by means of supplementing a certain amount of nicotine, resveratrol, or SRT 1720. Changes in NAD+ levels can regulate various physiological activities, such as DNA damage repair, carbohydrate metabolism and lipid metabolism, T cell activation, insulin release, the synthesis and degradation of proteins, the transmembrane signal transduction of cells and cellular senescence.

专利号:US-11028118-B2
优先权日:2015-03-27
标题:Efficient synthesis of nicotinamide mononucleotide
发明人：SAUVE ANTHONY; MOHAMMED FARHEEN SULTANA YANG
权利人:UNIV CORNELL
摘要:The invention provides a process for the preparation of nicotinamide mononucleotide having formula (I): n nThe method involves the protection of nicotinamide riboside by ketalization, followed by phosphorylation and then deprotection to provide nicotinamide mononucleotide.