CAS: 147804-30-6; Tert-Butyl 1-Oxa-6-Azaspiro[2.5]Octane-6-Carboxylate

上下游产品

N-叔丁氧羰基-4-哌啶酮 N-Tert-Butyloxycarbonylpiperidin-4-One 79099-07-3
N-Boc-4-亚甲基哌啶 Tert-Butyl 4-Methylidenepiperidine-1-Carboxylate 159635-49-1

4-乙烯基-哌啶置于间氯过氧苯甲酸体系中,用 氯仿 用作溶剂,化学反应 0.5H,以90.2%的收率获得1-噁-6-氮杂螺[2.5]辛烷-6-羧酸-1,1-二甲基乙酯
参考文献: Antibacterial Aminoglycoside Analogs[fr] Analogues D'Aminoglycosides Antibactériens
标题: Antibacterial Aminoglycoside Analogs[fr] Analogues D'Aminoglycosides Antibactériens
摘要:结构(i)的化合物具有抗菌活性,包括立体异构体,药用可接受的盐和前药,其中q1,Q2,Q3,R8和r9如本文所定义.还公开了与制备和使用这些化合物相关的方法,以及包含这些化合物的药物组合物.

专利信息

专利号:US-6593347-B2
优先权日:1998-10-30
标题 :Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：BANDARAGE UPUL K; DONG QING; FANG XINQIN; GARVEY DAVID S; MERCER GREGORY J; RICHARDSON STEWART K; SCHROEDER JOSEPH D; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.

专利号:WO-2009011653-A1
优先权日:2007-07-17
标题:A process for the preparation of intermediates and their us in the synthesis of spiropiperidine compounds

专利号:US-9168248-B2
优先权日:2009-02-17
标 题:Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
发明人：LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LI CHUN SING; MORADEI OSCAR MIGUEL
权利人:LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LI CHUN SING; MORADEI OSCAR MIGUEL; MERCK CANADA INC
摘要:Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-8785632-B2
优先权日:2004-08-26
标 题:Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
发明人：CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE
权利人:CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE; AGOURON PHARMA; PFIZER
摘要:Enantiomerically pure compound of formula 1 n nare provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

专利号:AU-2007275931-A1
优先权日:2006-07-19
标 题:Novel tricyclic spiropiperidine compounds, their synthesis and their uses as modulators of chemokine receptor activity

专利号:AU-2007275931-B2
优先权日:2006-07-19
标题:Novel tricyclic spiropiperidine compounds, their synthesis and their uses as modulators of chemokine receptor activity