CAS: 159414-97-8; N-(1-((2R,3R,4R,5R)-3-Fluoro-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-2-Oxo-1,2-Dihydropyrimidin-4-yl)Acetamide

英文名称N-(1-((2R,3R,4R,5R)-3-Fluoro-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-2-Oxo-1,2-Dihydropyrimidin-4-yl)Acetamide
中文名称N4-乙酰基-2'-氟脱氧胞苷
IUPAC名称N-(1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide
其它别名N-Acetyl-2′-Deoxy-2′-Fluorocytidine; N4-Acetyl-2'-Fluoro-2'-Deoxycytidine ; N4-Acetyl-2'-Deoxy-2'-Fluorocytidine; N-[1-[(2R,3R,4R,5R)-3-Fluoro-4-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]-2-Oxopyrimidin-4-Yl]Acetamide ; N-(1-((2R,3R,4R,5R)-3-Fluoro-4-Hydroxy-5
CAS编号159414-97-8
MFCD编号:MFCD15145138
分子式:C11H14FN3O5
分子量:287.24
产品CID: 797562
产品分类生物化工 → 核苷类药物 → 脱氧核苷酸及其类似物

相似结构搜索
InChIKey: NLXVKEFNBVLDLD-PEBGCTIMSA-N
InChI=1S/C11H14FN3O5/c1-5(17)13-7-2-3-15(11(19)14-7)10-8(12)9(18)6(4-16)20-10/h2-3,6,8-10,16,18H,4H2,1H3,(H,13,14,17,19)/t6-,8-,9-,10-/m1/s1…
计算化学: 氢键受体数6.0氢键供体数3.0可旋转键数3.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P305+P351+P338

上下游产品

acetic anhydride 2'-deoxy-2'-fluor°Cytidine

合成工艺路线路线简述

2'-Fluoro-2'-Deoxycytidine Hydrochloride置于吡啶,乙酸酐,三乙胺体系中,用甲醇,乙醚,N,N-二甲基甲酰胺用作溶剂,以71%的收率获得n4-乙酰基-2'-氟脱氧胞苷
参考文献:Oligoribonucleotide And Ribozyme Analogs With Terminal 3'-3' And/or 5'-5' Linkages
标题:Oligoribonucleotide And Ribozyme Analogs With Terminal 3'-3' And/or 5'-5' Linkages
摘要:该发明涉及具有末端3'-3'和/或5'-5'核苷酸间连接的寡核苷酸类似物.这种修饰稳定了以这种方式改变的分子,包括核酶,而不会对它们的性质产生不利影响,包括在适当情况下的催化活性.