CAS: 1642288-47-8; (S)-3-Isopropyl-6-((1-Phenylethyl)Amino)Pyrimidine-2,4(1H,3H)-Dione

相似化合物

5759-79-5 5759-80-8 2098044-24-5

上下游产品

S)-1-phenyl-ethylamine(S)-1-phenyl-ethylamine 1-isopropylpyrimidine-2,4,6(1H,3H,5H)trione

1-异丙基嘧啶-2,4,6(1H,3H,5H)-三酮置于苄基三乙基氯化铵,三氯氧磷体系中,用 1,4-二氧六环 用作溶剂,化学反应生成玛伐凯泰
参考文献: Pyrimidinedione Compounds Against Cardiac Conditions[fr] Composés De Pyrimidine-Dione Contre Les Affections Cardiaques
标题: Pyrimidinedione Compounds Against Cardiac Conditions[fr] Composés De Pyrimidine-Dione Contre Les Affections Cardiaques
摘要:提供了新型嘧啶二酮化合物及其药用盐,可用于治疗肥厚型心肌病(hcm)和与左心室肥厚或舒张功能障碍相关的病症.描述了这些化合物及其药用盐的合成和表征,以及治疗hcm和其他形式心脏疾病的方法.

专利信息

专利号:WO-2024218783-A1
优先权日:2023-04-17
标题 :Green chemistry approach for synthesis of mavacamten and its intermediate using novel methodology
发明人：CHEEPIRISHETTI SHANKAR; CHEEPIRISHETTI ASHRIT; KOMARRAJ SNEHITHA; KAUSHAL KISHORE; BORREDDY SIVA PRASAD REDDY; BASANTHI DEVI; SHAIK SAYYAD SHAMSHUDDIN; KUMAR MUKES
权利人:DASHA PHARMACEUTICALS PRIVATE LTD
摘要:The present invention discloses a green chemistry approach for synthesis of Mavacamten (Compound of formula I). The present invention also discloses a novel process for preparation of an intermediate 1-isopropylpyrimidine-2,4,6(1H,3H,5H)-trione (Compound of formula VII) and further preparation of Mavacamten using this intermediate, following novel methodology.

专利号:US-RE50050-E
优先权日:2013-06-21
标 题 :Pyrimidinedione compounds
发明人：OSLOB JOHAN; ANDERSON ROBERT; AUBELE DANIELLE; EVANCHIK MARC; FOX JONATHAN CHARLES; KANE BRIAN; LU PUPING; MCDOWELL ROBERT; RODRIGUEZ HECTOR; SONG YONGHONG; SRAN ARVINDER
权利人:MYOKARDIA INC
摘要:Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.