CAS: 17342-08-4; (S)-(+)-5-Hydroxymethyl-2-Pyrrolidinone

• 英文名称(S)-(+)-5-Hydroxymethyl-2-Pyrrolidinone
• 中文名称L-焦谷氨醇
• IUPAC名称(S)-5-(hydroxymethyl)pyrrolidin-2-one
• 其它别名(S)-5-羟甲基-2-吡咯烷酮; L焦谷氨醇; L-Pyroglutaminol
• CAS编号17342-08-4
• MFCD编号:MFCD00077792
• EINECS号:605-678-7
• 分子式:C5H9NO2
• 分子量:115.13
• 产品CID: 886662
• 产品分类有机原料→分子砌块→脂肪杂环类化合物→吡咯烷类化合物

• 相似结构搜索
• 产品信息参考;;;;
• InChIKey: HOBJEFOCIRXQKH-BYPYZUCNSA-N
• InChI=1S/C5H9NO2/c7-3-4-1-2-5(8)6-4/h4,7H,1-3H2,(H,6,8)/t4-/m0/s1…
• 计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数1.0

相似化合物

物理性质

• 熔点79-80°C
• 沸点346°C at 760 mmHg
• 闪点163.0±20.4 °C
• 密度1.2±0.1 g/cm3
• PH:30 º (C=2, ETOH)
• pKa:14.35±0.10(预测)
• PSA:49.33
• LogP:-0.7427
• 旋光度30º(C=2,ETOH)
• 折射率1.476
• 蒸汽压0.0±1.7 mmHg at 25°C
• 溶解性DMSO, Ethanol, Methanol
• 敏感性常温常压下稳定 避免的物料：氧化物
• 外观形态白色至淡黄色晶体或结晶粉末
• 储存条件惰性气氛,室温
• 产品应用(S)-(+)-5-羟甲基-2-吡咯烷酮(17342-08-4)的用途:本品可以用作医药中间体,也用于有机合成.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  严重眼刺激 类别2A
• 警示词Warning(警告)
• 危险描述H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
• 防范说明P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
• UN编号NONH for all modes of transport
• 危险品标志Xi
• 安全声明26-36-37/39
• 危险类别码36/37/38
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 4931-66-2 = 17342-08-4
  反应条件:1.1 Reagents: Sodium Borohydride Solvents: Ethanol
  标题:Late-Stage Diversification Of Chiral N-Heterocyclic-Carbene Precatalysts For Enantioselective Homoenolate Additions
  作者:Zheng,Pinguan; Gondo,Chenaimwoyo A.; Bode,Jeffrey W.
  参考文献:Chemistry - An Asian Journal 日期:2011 卷标:6(2) 页码:614-620]
  
  4931-66-2 = 17342-08-4
  反应条件:1.1 Reagents: Sodium Borohydride Solvents: Ethanol; Overnight,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:New Chiral Diamide Ligands: Synthesis And Application In Allylic Alkylation
  作者:Bateman,Lorraine; Breeden,Simon W.; O'Leary,Patrick
  参考文献:Tetrahedron: Asymmetry 日期:2008 卷标:19(3) 页码:391-396]
  
  3006017-87-1 = 17342-08-4
  反应条件:1.1 Solvents: Methanol,Acetone; 15 Min,Rt; 24 H,Rt
  标题:Benzoyldiisopropylchlorosilane: A Visible Light Photocleavable Alcohol Protecting Group
  作者:Lind,Florian; Markelov,Kirill; Studer,Armido
  参考文献:Chemical Science 日期:2023 卷标:14(44) 页码:12615-12620]
  
  4931-66-2 = 17342-08-4
  反应条件:1.1 Reagents: Sodium Borohydride Solvents: Ethanol
  标题:Synthesis Of New Optically Active 2-Pyrrolidinones
  作者:Moutevelis-Minakakis,Panagiota; Papavassilopoulou,Eleni; Mavromoustakos,Thomas
  参考文献:Molecules 日期:2013 卷标:18 页码:50-73]
  
  7149-65-7 = 17342-08-4
  反应条件:1.1 Reagents: Sodium Borohydride Solvents: Methanol
  标题:Approaches Towards The Synthesis Of Ebelactone-A Using Organosilicon Chemistry
  作者:Archibald,Sarah Catherine
  参考文献:1992]
  
  4931-66-2 = 17342-08-4
  反应条件:1.1 Reagents: Sodium Borohydride Solvents: Ethanol
  标题:Synthesis,In Silico Docking Experiments Of New 2-Pyrrolidinone Derivatives And Study Of Their Anti-Inflammatory Activity
  作者:Moutevelis-Minakakis,Panagiota; Papavassilopoulou,Eleni; Michas,George; Georgikopoulou,Kalliopi; Ragoussi,Maria-Eleni; Et Al
  参考文献:Bioorganic & Medicinal Chemistry 日期:2011 卷标:19(9) 页码:2888-2902]
  
  7149-65-7 = 17342-08-4
  反应条件:1.1 Reagents: Sodium Borohydride Solvents: Methanol
  标题:An Approach To The Synthesis Of Nonactic Acid
  作者:Duyck,Catherine
  参考文献:1991]
  
  4931-66-2 = 17342-08-4
  反应条件:1.1 Reagents: Sodium Borohydride Solvents: Ethanol,Water
  标题:Synthesis Of Novel Heterocyclic Compounds As Potential Pharmaceuticals
  作者:Bhattacharya,Kaberi
  参考文献:1991]
  
  98-79-3 = 17342-08-4
  反应条件:1.1 Reagents: Methanol,Thionyl Chloride; 2 H,-15 °C1.2 Reagents: Sodium Borohydride Solvents: Ethanol; 12 H,0 °C
  标题:Asymmetric Intramolecular Crossed-Benzoin Reactions By N-Heterocyclic Carbene Catalysis
  作者:Enders,Dieter; Niemeier,Oliver; Balensiefer,Tim
  参考文献:Angewandte Chemie 日期:2006 卷标:45(9) 页码:1463-1467]
  
  4931-66-2 = 17342-08-4
  反应条件:1.1 Reagents: Sodium Borohydride Solvents: Methanol,Tetrahydrofuran; -10 °C; < 5 °C; 1 H,< 5 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2,0 °C; 0 °C -> Rt; 3 H,Rt
  标题:Stereoselective Synthesis Of Trans-Threo-Trans-Oligopyrrolidines: Potential Agents For Rna Cleavage
  作者:Arndt,Hans-Dieter; Welz,Ruediger; Mueller,Sabine; Ziemer,Burkhart; Koert,Ulrich
  参考文献:Chemistry - A European Journal 日期:2004 卷标:10(16) 页码:3945-3962]
  
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  标题:Stereoselective Synthesis And Evaluation Of All Stereoisomers Of Z4349,A Novel And Selective μ-Opioid Analgesic
  作者:Napoletano,M.; Della Bella,D.; Fraire,C.; Grancini,G.; Masotto,C.; Et Al
  参考文献:Bioorganic & Medicinal Chemistry Letters 日期:1995 卷标:5(6) 页码:589-92]
  
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  标题:The Stereochemistry Of Electrophilic Attack On Chiral Dienylmethylsilanes
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  参考文献:1992]
  
  7149-65-7 = 17342-08-4
  反应条件:1.1 Reagents: Sodium Borohydride Solvents: Methanol
  标题:Studies Directed Towards The Synthesis Of (-)-Ebelactone A
  作者:Mandal,Ajay K.
  参考文献:1999]
  
  98-79-3 = 17342-08-4
  反应条件:1.1 Reagents: Methanol,Thionyl Chloride Solvents: Methanol; Rt1.2 Reagents: Sodium Borohydride Solvents: Ethanol; Rt
  标题:First Total Synthesis Of Oteromycin Utilizing One-Pot Four-Step Cascade Reaction Strategy
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海关参考信息

• 2905121000-正丙醇
  2905130000-正丁醇
  2912110000-甲醛
  2912120000-乙醛
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• 详情请参考：📖 海关编码查询和海关进出口税则

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