CAS: 19009-39-3; Diisopropylcarbamoyl Chloride

该化合物是一种多用途的氯化碳化物衍生物,广泛用作有机合成的中间体,特别是在生产药品和农用化学品方面,其主要优点包括作为碳化物剂的高度活性,能够有效地将二异丙基碳酸乙基化合物组引入目标分子;该化合物在受控条件下具有良好的稳定性,便于处理和储存;该化合物与胺和酒精的选择性反应作用使得它对于制造氨酸盐和尿素衍生物具有价值;二异丙基碳酸乙基氯在摇头丸的修改和活性药物成分合成方面特别有用,因为二异丙基碳酸酯的结构受到阻碍,会影响最终产品的合成基因特性.

结构式图片

相似化合物

2700-30-3 88-10-8 42252-34-6

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号75-44-5 光气 | CAS号108-18-9 二异丙胺 | CAS号4136-91-8 四异丙基二硫化秋兰姆 | CAS号32315-10-9 三光气 | CAS号20652-39-5 N,N-DIISOPROPYL... | CAS号2700-30-3 二异丙基甲酰胺 | CAS号503-38-8 氯甲酸三氯甲酯 | CAS号218601-55-9 3-phenylpropyl ... | CAS号20652-39-5 N,N-DIISOPROPYL... | CAS号26382-04-7 benzyl N,N-di(p... | CAS号65367-56-8 1-hydroxy-N,N-d... | CAS号81555-24-0 but-2-enyl N,N-... | CAS号87143-44-0 cyclopenten-1-y... | CAS号57124-37-5 S-methyl N,N-di... | CAS号51861-45-1 S-cyclohex-2-en... | CAS号51893-18-6 S-propyl N,N-di...

合成工艺路线路线简述

  • 合成目标产物 Diisopropylcarbamoyl Chloride 主要起始原料 Tetraisopropylthiuram Disulfide
  • (文献来源)合成步骤主要原料 Tetraisopropylthiuram Disulfide
Ethyl Diisopropylcarbamate置于三氯氧磷体系中,用 乙腈 用作溶剂,化学反应 20.0H,以48.1%的收率获得二异丙基甲胺酰氯
参考文献:Hoshino,Osamu; Saito,Keiji; Ishizaki,Miyuki,Synthetic Communications,1987,Vol. 17,# 16,P. 1887-1892
标题:Hoshino,Osamu; Saito,Keiji; Ishizaki,Miyuki,Synthetic Communications,1987,Vol. 17,# 16,P. 1887-1892

海关参考信息

专利信息


专利号:US-8273790-B2
优先权日:2005-01-14
标 题:Exo-selective synthesis of himbacine analogs
发明人:THIRUVENGADAM TIRUVETTIPURAM K; SUDHAKAR ANANTHA; LIM NGIAP KIE; KWOK DAW-IONG; WU GEORGE G; WANG TAO; HUANG MINGSHENG; GREEN MICHAEL D
权利人:THIRUVENGADAM TIRUVETTIPURAM K; SUDHAKAR ANANTHA; LIM NGIAP KIE; KWOK DAW-IONG; WU GEORGE G; WANG TAO; HUANG MINGSHENG; GREEN MICHAEL D; SCHERING CORP
摘要:This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:

专利号:US-2025179012-A1
优先权日:2022-03-04
标 题:Synthesis of sulfur(vi) compounds and reagents for same
发明人:LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

专利号:US-11655255-B2
优先权日:2022-10-17
标题 :Method for catalytic asymmetric synthesis of phosphorus-stereogenic (P-stereogenic) nucleoside derivative and catalyst used therein
发明人:ZHANG WANBIN; WANG MO; ZHANG LU; HUO XIAOHONG; ZHANG ZHENFENG; YUAN QIANJIA; CHEN JIANZHONG
权利人:SPH NO 1 BIOCHEMICAL & PHARMACEUTICAL CO LTD; UNIV SHANGHAI JIAOTONG
摘要:A method for catalytic asymmetric synthesis of a phosphorus-stereogenic (P-stereogenic) nucleoside derivative of formula (3) and a catalyst used therein. The P-stereogenic nucleoside derivative (3) can be hydrolyzed to obtain remdesivir. Specifically, a nucleoside and phosphoryl chloride are subjected to asymmetric reaction under the catalysis of a chiral bicyclic imidazole catalyst in the presence of a base to produce the P-stereogenic nucleoside derivative of formula (3)

专利号:WO-2025101716-A1
优先权日:2023-11-07
标题:Processes for synthesis of trifunctionalized sulfur(vi) compounds
发明人:LOPCHUK JUSTIN; SHULTZ ZACHARY; ATHAWALE PARESH
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure describes processes for the asymmetric synthesis of trifunctionalized sulfur(VI) containing organic compounds of Formula I and Formula VI, as well as compounds of Formula I and Formula VI prepared by the processes described.

专利号:US-9650355-B2
优先权日:2013-01-31
标 题 :Method for preparation of justicidin a derivatives of arylnaphthalene lignan structure
发明人:HAM JUNGYEOB; KIM TAE JUNG; KWON HAK CHEOL; JEONG KYU HYUK; SONG JUNGHO; CHUNG BONG CHUL
权利人:KOREA INST SCI & TECH
摘要:The present disclosure relates to a novel method for preparing an arylnaphthalene lignan compound. In synthesis of arylnaphthalene lignan compounds and derivatives according to the present disclosure, a naphthalene backbone may be constructed first and an aryl group may be introduced at the final stage. Through this, various kinds of derivatives that could not be prepared from the existing methods can be synthesized effectively. Further, the synthesis method according to the present disclosure is appropriate for large-scale production.

专利号:US-7074932-B2
优先权日:1999-06-24
标题 :Preparation of quinoline-substituted carbonate and carbamate derivatives
发明人:ALLEN MICHAEL S; PREMCHANDRAN RAMIYA H; CHANG SOU-JEN; CONDON STEPHEN; DEMATTEI JOHN A; KING STEVEN A; KOLACZKOWSKI LAWRENCE; MANNA SUKUMAR; NICHOLS PAUL J; PATEL HEMANT H; PATEL SUBHASH R; PLATA DANIEL J; STONER ERIC J; TIEN JIEN-HEH J; WITTENBERGER STEVEN J
权利人:ALLEN MICHAEL S; PREMCHANDRAN RAMIYA H; CHANG SOU-JEN; CONDON STEPHEN; DEMATTEI JOHN A; KING STEVEN A; KOLACZKOWSKI LAWRENCE; MANNA SUKUMAR; NICHOLS PAUL J; PATEL HEMANT H; PATEL SUBHASH R; PLATA DANIEL J; STONER ERIC J; TIEN JIEN-HEH J; WITTENBERGER STEVEN J
摘要:The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.
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主要参考文献

参考标题:Stereocontrolled Synthesis Of Adjacent Acyclic Quaternary-Tertiary Motifs: Application To A Concise Total Synthesis Of (−)-Filiformin
作者:Daniel J. Blair,Catherine J. Fletcher,Katherine M. P. Wheelhouse,Varinder K. Aggarwal |发布日期:2014.5.26
摘要:Developed For The Synthesis Of Acyclic Quaternary‐tertiary Motifs With Full Control Of Relative And Absolute Stereochemistry, Thus Leading To All Four Possible Isomers Of A Stereodiad. A Novel Intramolecular Zweifel‐type Olefination Enabled Acyclic Stereocontrol To Be Transformed Into Cyclic Stereocontrol. These Key Steps Have Been Applied To The Shortest Enantioselective Synthesis Of (−)‐filiformin

合成参考文献


摘要:Okamoto, K.; Ohe, K., Science of Synthesis Knowledge Updates, (2020) 1, 75.
摘要:Clark, T. B.; Cho, H. Y., Science of Synthesis: Advances in Organoboron Chemistry towards Organic Synthesis, (2019) 1, 148.
摘要:Gong, T.-J.; Ahmed, E.-A. M. A.; Fu, Y., Science of Synthesis: Advances in Organoboron Chemistry towards Organic Synthesis, (2019) 1, 483.
摘要:Aiken, S. G.; Bateman, J. M.; Aggarwal, V. K., Science of Synthesis: Advances in Organoboron Chemistry towards Organic Synthesis, (2019) 1, 400.
摘要:Miyagishi, H. V.; Nagaki, A., Science of Synthesis: Knowledge Updates, (2024) 1, 234.
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