CAS: 19757-97-2; Methyl 2-Hydroxy-2-Methoxyacetate

相似化合物

563-96-2 73569-40-1 18370-95-1

上下游产品

furfural methanol Glyoxilic acid GlyoxalMethyl dimethoxyacetate methyl 2-(tert-butoxycarbonylamino)-2-hydroxyacetate (2R,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-°Ctahydro-benzo[e][1,3]oxazine-2-carboxylic acid methyl ester -°Ctahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzooxazine-2-carboxylatemethyl 2S(2α,4aα,7α,8aβ)-°Ctahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzooxazine-2-carboxylate

甲酸甲酯置于sodium Hydroxide,Wang Resin-Pentylstyrene[5-Ph(4Me)]N-Me-Imidazole(1+)*cl(1-)体系中,用 四氢呋喃 用作溶剂,化学反应 1.5H,以41%的收率获得2-羟基-2-甲氧基乙酸甲酯
参考文献:Imidazole Based Solid-Supported Catalysts For The Benzoin Condensation
标题:Imidazole Based Solid-Supported Catalysts For The Benzoin Condensation
摘要:New Polymer-Supported Imidazolium Salts Have Been Synthesised,And Their Utility As Pre-Catalysts In The Benzoin Reaction Has Been Demonstrated. (C) 2005 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetlet.2005.08.141

专利信息

专利号:US-9969685-B2
优先权日:2016-09-28
标 题 :Enantioselective synthesis of pyrroloindole compounds
发明人：SCHMIDT MICHAEL ANTHONY
权利人:BRISTOL MYERS SQUIBB CO
摘要:Compounds according to formula (I) or (II), wherein R 1 , R 2 , and R 3 are as defined in the specification, are versatile intermediates for the synthesis of DNA minor groove binder-alkylators having a cyclopropapyrroloindole (CPI) or seco-CPI alkylating subunit.

专利号:US-4424389-A
优先权日:1981-04-30
标 题:Synthesis of 6-hydroxychroman-2-methanol derivatives
发明人：SAKITO YOJI
权利人:SUMITOMO CHEMICAL CO
摘要:A process for producing chroman, a compound of the formula, ##STR1## or an optically active compound thereof wherein R 2 , R 3 and R 4 are each a hydrogen atom or a C 1 -C 4 alkyl group, which comprises reacting a compound of the formula, ##STR2## or an optically active compound thereof wherein A is an aryl group and R 5 is a C 1 -C 4 alkyl group, with a compound of the formula, ##STR3## wherein R 1 is a C 1 -C 3 alkyl group, X is a halogen atom and R 2 , R 3 and R 4 are as defined above, to obtain a compound of the formula, ##STR4## or an optically active compound thereof wherein A, R 1 , R 2 , R 3 and R 4 are as defined above, reacting the resulting compound with methylmagnesium halide and then hydrolyzing to obtain the corresponding 4-aryl substituted 2-hydroxy-2-methylbutanal, or an optically active compound thereof, reducing the resulting compound to obtain a diol, or an optically active compound thereof, and then oxidizing the resulting compound to obtain a compound of the formula, ##STR5## or an optically active compound thereof wherein R 2 , R 3 and R 4 are as defined above, followed by reduction. n Chromans, the objective compounds of this invention, are an intermediate for the synthesis of tocopherols, particularly α-tocopherol.

专利号:US-8324417-B2
优先权日:2009-08-19
标题:Process for the preparation of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid and alkyl esters and acid salts thereof
发明人：HART BARRY; DENER JEFF; GREEN MICHAEL; STANDEN MICHAEL; KOCIAN OLDRICH
权利人:HART BARRY; DENER JEFF; GREEN MICHAEL; STANDEN MICHAEL; KOCIAN OLDRICH; VIROBAY INC
摘要:The present invention relates to a process for the preparation of alkyl esters of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid, which are intermediates useful in the synthesis of (S)—N-(1-cyanocyclopropyl)-5-cyclopropyl-4,4-difluoro-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanamide and related compounds, which are compounds that are cysteine protease inhibitors.

专利号:US-9718807-B2
优先权日:2012-06-05
标 题 :Synthesis of antiviral compound
发明人：SCOTT ROBERT WILLIAM; VITALE JUSTIN PHILIP; MATTHEWS KENNETH STANLEY; TERESK MARTIN GERALD; FORMELLA ALEXANDRA; EVANS JARED WAYNE
权利人:GILEAD PHARMASSET LLC
摘要:The present disclosure provides processes for the preparation of a compound of formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula I.

专利号:US-7205300-B2
优先权日:1997-12-31
标 题:Aryl fused azapolycyclic compounds
发明人：COE JOTHAM WADSWORTH; BROOKS PAIGE ROANNE PALMER
权利人:PFIZER
摘要:This invention is directed to compounds of the formula (I): n nand their pharmaceutically acceptable salts, wherein R 1 , R 2 , and R 3 are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such compounds; and methods of using such compounds in the treatment of neurological and psychological disorders.

专利号:WO-2018064094-A1
优先权日:2016-09-28
标题:Enantioselective synthesis of pyrroloindole compounds