CAS: 2369-19-9; 2-Fluoro-5-Methylpyridine

相似化合物

853909-08-7 2369-18-8 111887-71-9

上下游产品

CAS号1603-41-4 2-氨基-5-甲基吡啶 | CAS号108-99-6 3-甲基吡啶 | CAS号75-05-8 乙腈 | CAS号403-45-2 6-氟烟酸 | CAS号65352-94-5 2-氟吡啶-5-甲酰氯 | CAS号402-69-7 6-氟-2-吡啶甲酸 | CAS号39891-05-9 6-氟-3-羟甲基吡啶 | CAS号105827-74-5 5-溴甲基-2-氟吡啶 | CAS号1072952-45-4 2-氟-5-甲基吡啶-3-硼酸 | CAS号1003-68-5 2-羟基-5-甲基吡啶 | CAS号153034-94-7 2-氟-4-碘-5-甲基吡啶 | CAS号153034-78-7 2-氟-3-碘-5-甲基吡啶 | CAS号1620-77-5 2-氰基-5-甲基吡啶

2-氨基-5-甲基吡啶置于tetrafluoroboric Acid,Sodium Nitrite体系中,化学反应 1.0H,以45%的收率获得2-氟-5-甲基吡啶
参考文献:2-氰基-3-(2-氟-5-吡啶基)甲基氨基丙烯酸酯的合成及除草活性
标题:2-氰基-3-(2-氟-5-吡啶基)甲基氨基丙烯酸酯的合成及除草活性
摘要:一系列的2-氰基-3-(2-氟-5--吡啶基)methylaminoacrylates合成为光系统ii(psii)电子传输的除草抑制剂.由2-氨基-5-甲基吡啶制备2-氟-5-吡啶甲胺,随后与2-氰基-3,3-二甲基硫代丙烯酸酯或2-氰基-3-甲氧基丙烯酸酯反应,得到这些标题化合物.所有这些化合物均通过1 H NMR,Ir,质谱和元素分析确认.对它们的除草活性进行了评估.在出苗后的处理中,所有标题化合物均对a菜和杂菜表现出优异的除草活性.以150 G / Ha的速率,一种化合物表现出与cl-类似物相似的活性.用氟基团代替氯显示出相同的除草活性.
Doi:10.1016/j.Jfluchem.2004.12.015

专利信息

专利号:US-2023286918-A1
优先权日:2020-07-02
标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat
发明人：JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER
权利人:AKEBIA THERAPEUTICS INC
摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.

专利号:WO-2024137329-A1
优先权日:2022-12-20
标 题:Methods for the synthesis of complement factor d inhibitors and intermediates thereof
发明人：HASHIMOTO AKIHIRO; TIPPARAJU SURESH KUMAR
权利人:ALEXION PHARMA INC
摘要:The present disclosure provides methods for the synthesis of complement factor D inhibitors and intermediates thereof.

专利号:US-2023399302-A1
优先权日:2020-10-29
标题:Process for the preparation of heteroaryl-substituted sulfur(vi) compounds
发明人：LOPCHUK JUSTIN M; SHULTZ ZACHARY P; SCATTOLIN THOMAS
权利人:H LEE MOFFITT CANCER CT & RES
摘要:The present disclosure provides processes for the synthesis of organic compounds, in particular processes for the synthesis of heteroaryl-substituted sulfur(VI) compounds by nucleophilic aromatic substitution.

专利号:US-2021238374-A1
优先权日:2020-02-04
标 题 :Templated synthesis of nanovoided polymers
发明人：YE SHENG; LANDIG RENATE EVA KLEMENTINE; DIEST KENNETH ALEXANDER; OUDERKIRK ANDREW JOHN; BOWMAN CHARLES ROBERT; BOWMAN ROBERT G; HENDRICKSON WILLIAM ARTHUR; RUEB CHRISTOPHER J; PURVIS II LAFE JOSEPH; SUN WENMO; LI RYAN; YAROSHCHUK OLEG; RAO TINGLING; BOROMAND ARMAN; ZHAO CHURNING; Khaleghimeybodi Morteza
权利人:FACEBOOK TECH LLC
摘要:A method of forming a voided polymer includes forming a polymerizable composition containing a polymer precursor and a solid templating agent, forming a coating of the polymerizable composition, processing the coating to form a cured polymer material having a solid phase in a plurality of defined regions, and removing at least a portion of the solid phase from the cured polymer material to form a voided polymer layer.

专利号:US-9242998-B2
优先权日:2013-02-07
标题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C
发明人：HE SHUWEN; DAI XING; PALANI ANANDAN; NARGUND RAVI; LAI ZHONG; ZORN NICOLAS; XIAO DONG; DANG QUN; MCCOMAS CASEY C; LI PENG; PENG XUANJIA; SOLL RICHARD
权利人:HE SHUWEN; DAI XING; PALANI ANANDAN; NARGUND RAVI; LAI ZHONG; ZORN NICOLAS; XIAO DONG; DANG QUN; MCCOMAS CASEY C; LI PENG; PENG XUANJIA; SOLL RICHARD; MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9243002-B2
优先权日:2013-02-07
标题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C
发明人：DAI XING; LIU HONG; PALANI ANANDAN; HE SHUWEN; BROCKUNIER LINDA L; NARGUND RAVI; MARCANTONIO KAREN; ZORN NICOLAS; XIAO DONG; PENG XUANJIA; LI PENG; GUO TAO
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.