CAS: 2987-16-8; 3,3-Dimethylbutanal

相似化合物

624-95-3 1070-83-3 5340-78-3

上下游产品

CAS号1070-83-3 3,3-二甲基丁酸 | CAS号624-95-3 3,3-二甲基-1-丁醇 | CAS号917-92-0 3,3-二甲基-1-丁炔 | CAS号7065-46-5 3,3-二甲基丁酰氯 | CAS号107-86-8 异戊烯醛 | CAS号89984-56-5 chloromethane,m... | CAS号7518-70-9 1-ethoxyethanol | CAS号110166-45-5 2-neopentylbenz... | CAS号6130-96-7 1,1-二氯-3,3-二甲基丁烷 | CAS号1052703-81-7 N-(3,3-二甲基丁基)-3... | CAS号3850-30-4 3,3-二甲基-2-丁胺 | CAS号216574-71-9 2-氨基-5-叔丁基噻吩-3-甲酸甲酯 | CAS号299417-31-5 5-叔丁基噻唑-2-胺 | CAS号24499-80-7 5,5-二甲基己酸 | CAS号1070-83-3 3,3-二甲基丁酸 | CAS号23361-67-3 1-Propanol,2,2-... | CAS号79777-82-5 (S) -2-((叔丁氧羰基)... | CAS号540-80-7 亚硝酸叔丁酯 | CAS号926-05-6 tert-butyl nitrate

1-Chloro-3,3-Dimethylbutyl Acetate置于水体系中,用 甲醇 用作溶剂,化学反应 3.0H,以97.5%的收率获得3,3-二甲基丁醛
参考文献:一种1-氯-3,3-二甲基丁基乙酸酯的水解方法
标题:一种1-氯-3,3-二甲基丁基乙酸酯的水解方法
摘要:本发明属于化工技术领域,具体涉及一种1-氯-3,3-二甲基丁基乙酸酯的水解方法.该1-氯-3,3-二甲基丁基乙酸酯的水解方法,包括以下步骤:将1-氯-3,3-二甲基丁基乙酸酯缓慢加入到醇水混合溶液中升温进行反应,反应温度为20oc~60°C,反应时间为2~4H,反应结束后升温精馏,收集99oc~102oc馏分,得到3,3-二甲基丁醛.本发明采用水和甲醇的混合溶液作用作溶剂,使1-氯-3,3-二甲基丁基乙酸酯与溶剂更好的混合,无需加入催化剂,在温和条件下即发生水解,极大的避免了高温聚合副产物的产生,甲醇可回收重复利用,进一步节约成本,减少了废水废气的排放,进一步减轻了环保压力,操作简单,适合工业化生产.

专利信息

专利号:US-11542269-B2
优先权日:2018-01-03
标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHOI HYEONG-WOOK; FANG FRANCIS G
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-10913749-B2
优先权日:2015-05-07
标 题 :Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-11136335-B2
优先权日:2016-06-30
标题:Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHASE CHARLES E; CHOI HYEONG-WOOK; ENDO ATSUSHI; FANG FRANCIS G; KIM DAE-SHIK
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.

专利号:US-9783549-B2
优先权日:2013-11-04
标题:Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E; LEE JAEMOON
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

专利号:US-2010087658-A1
优先权日:1996-08-06
标 题 :Methods and intermediates for synthesis of selective dpp-iv inhibitors
发明人：CAMPBELL DAVID ALAN; LEITAO EMILIA P T; WU ZHEN-PING; WANG PENG
权利人:PHENOMIX CORP
摘要:Methods and intermediates for the synthesis of selective inhibitors of dipeptidyl peptidase IV (DPP-IV) are provided. Coupling of a carboxylate salt with a boro-proline derivative provides a protected form of a DPP-IV inhibitor, which may be deblocked to yield the medicinal compound. The carboxylate salt can be a crystalline form of a sodium salt or a dicyclohexylammonium salt. The inhibitor can be used in the treatment of diabetes.

专利号:US-2024024497-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to methods for the synthesis of conjugates useful for the treatment of viral infections, e.g., conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir or an analog thereof) linked to an Fc domain monomer.