CAS: 3181-38-2; (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(6-Oxo-1H-Purin-9(6H)-yl)Tetrahydrofuran-3,4-Diyl Diacetate

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CAS号108-24-7 乙酸酐 | CAS号58-63-9 肌苷 | CAS号112-55-0 十二硫醇 | CAS号5987-73-5 2,3,5-三-O-乙酰基-6... | CAS号16645-06-0 N,N-二甲基羟胺盐酸盐 | CAS号41623-91-0 [(2R,3R,4R,5R)-... | CAS号87781-93-9 2-溴次黄嘌呤 | CAS号39824-26-5 6-氯嘌呤-9-(2,3-异亚... | CAS号4294-16-0 N6-苄基腺苷 | CAS号5987-73-5 2,3,5-三-O-乙酰基-6... | CAS号2140-73-0 1-甲基肌苷 | CAS号33763-06-3 7-methylinosine | CAS号5746-29-2 Inosine, 6-O-methyl | CAS号65-46-3 胞嘧啶核苷 | CAS号26293-51-6 Adenosine, N-pe... | CAS号1867-73-8 N6-甲基腺苷 | CAS号2004-06-0 6-氯嘌呤核苷

2-溴次黄嘌呤置于palladium On Activated Charcoal 三氟甲磺酸三甲基硅酯,氢气,溶剂黄146,1,8-二氮杂双环[5.4.0]十一碳-7-烯,三乙胺,三苯基膦,偶氮二甲酸二乙酯体系中,用 乙腈 用作溶剂,25.0~100.0 °C,413.69 Kpa 条件下,反应 41.0H,反应生成2',3',5'-三乙酰肌苷
参考文献:有效的区域选择性合成鸟嘌呤和肌苷的取代嘌呤类似物
标题:有效的区域选择性合成鸟嘌呤和肌苷的取代嘌呤类似物
摘要:作为三甲基甲硅烷基衍生物(5A)的2-溴-6-(4-硝基苯基乙氧基)嘌呤与1,2,3,5-四-O-乙酰基-β-D-呋喃核糖,1-O-乙酰基-2,3-二-O-苯甲酰基-5-二乙氧基-次膦酰基-β-D-呋喃呋喃糖和(2-乙酰氧基乙氧基)甲基溴导致n 9-区域选择性烷基化,得到(6A-C),然后将其转化为鸟嘌呤和次黄嘌呤核苷,核苷酸和阿昔洛韦类似物.
Doi:10.1039/c39890001769

专利信息

专利号:US-7855285-B2
优先权日:2005-06-14
标 题:Methods for selective N-9 glycosylation of purines
发明人：ROBINS MORRIS J; ZHONG MINGHONG
权利人:UNIV BRIGHAM YOUNG
摘要:A process for providing regiospecific and highly stereoselective synthesis of 9-β anomeric purine nucleoside analogs is described. The introduction of the sugar moiety on to 6-(azolyl)-substituted purine bases is performed so that highly stereoselective formation of the β anomers of only the 9 position regioisomers of the purine nucleoside analogs (either D or L enantiomers) is obtained. This regiospecific and stereoselective introduction of the sugar moiety allows the synthesis of nucleoside analogs, and in particular 2′-deoxy, 3′-deoxy, 2′-deoxy-2′-halo-arabino and 2′,3′-dideoxy-2′-halo-threo purine nucleoside analogs, in high yields without formation of the 7-positional regioisomers. Processes for providing novel 6-(azolyl)purines for the regiospecific and highly stereoselective synthesis of 9-β anomeric purine nucleoside analogs are described. The compounds are drugs or intermediates to drugs.

专利号:CN-102675391-A
优先权日:2011-12-20
标 题:Chemical Synthesis of Adenosine