CAS: 344329-76-6; Tetrahydro-2H-Pyran-4-Carboxamide

相似化合物

4295-99-2 389621-78-7 130290-79-8

上下游产品

CAS号110238-91-0 四氢吡喃-4-羧酸甲酯 | CAS号40191-32-0 4-氢吡喃-4-甲酰氯 | CAS号5337-03-1 四氢吡喃-4-甲酸 | CAS号4295-99-2 4-氰基四氢吡喃 | CAS号38041-19-9 4-氨基四氢吡喃 | CAS号130290-79-8 4-氨甲基四氢吡喃 | CAS号88571-77-1 四氢-2H-吡喃-4-硫代甲硫酰胺

4-氰基四氢吡喃置于sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应生成 4-甲酰胺基吡喃
参考文献:4-氨基四氢吡喃的一锅法合成工艺
标题:4-氨基四氢吡喃的一锅法合成工艺
摘要:本发明公开了一种4-氨基四氢吡喃的一锅法合成工艺,以4-氰基四氢吡喃,氢氧化钠溶液(或氢氧化钾溶液)为原料合成4-甲酰胺四氢吡喃,再往4-甲酰胺四氢吡喃中缓慢加入次氯酸钠溶液(或次溴酸钠溶液),随后加热升温至回流,脱羧反应生成产物4-氨基四氢吡喃.将所有反应原料放在一锅中反应,通过选择合适的反应条件,合成4-氨基四氢吡喃,选择性高,杂质少,中间产物不用分离,收率高,实用价值高.

专利信息

专利号:WO-2025128848-A1
优先权日:2023-12-12
标题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:US-7858809-B2
优先权日:2004-04-12
标题 :Process for production of pyrazole-fused ring derivatives
发明人：NEGI SHIGETO; SHIMIZU TOSHIKAZU; KURODA HIROSHI; SHIMOMURA NAOYUKI; SASHO MANABU; HOSHINO YORIHISA; KUBOTO MANABU
权利人:EISAI R&D MAN CO LTD
摘要:Intermediates useful for the synthesis of pyrazole-fused ring derivatives, such as 7-phenylpyrazolo [1,5-a]pyridine derivatives, and method for producing the same. Method for producing compound represented by the general formula (II), wherein Z 1 and Z 2 each independently represents a methine group or a nitrogen atom; R l represents an ethyl group or the like; R 5 represents a hydrogen atom or the like; R 2 and R 3 each independently represents a C 1-6 alkyl group or the like, salts thereof, or solvates of both, comprising the step of: reacting a compound represented by the general formula (I), wherein Z 1 , Z 2 , R 5 , R 1 , R 2 and R 3 each has the same definition as described above, with an organometallic reagent; and then reacting the resulting product with pentafluoroiodobenzene.

专利号:CN-102993144-B
优先权日:2012-12-07
标 题 :One-pot synthesis of 4-aminotetrahydropyran

专利号:CN-102993144-A
优先权日:2012-12-07
标 题 :One-pot synthesis of 4-aminotetrahydropyran

专利号:WO-2005106495-A1
优先权日:2004-05-04
标题 :Procollagen ii biomarkers and methods
发明人：ABRAMS MARK ALLAN; AGGARWAL POONAM PEREIRA; DUFIELD DAWN RENE; MATHEWS RODNEY W; NEMIROVSKIY OLGA VLADIMIROVNA; SUNYER TERESA
权利人:PHARMACIA & UPJOHN CO LLC; ABRAMS MARK ALLAN; AGGARWAL POONAM PEREIRA; DUFIELD DAWN RENE; MATHEWS RODNEY W; NEMIROVSKIY OLGA VLADIMIROVNA; SUNYER TERESA
摘要:A method of prediction disease progression in a disorder characterized by the uncoupling of collagen type II synthesis and degradation is disclosed. There is further disclosed a method of detecting specific procollagen fragments associated with osteoarthritis. The fragments are derived from procollagen type IIB (PIIBNP). A method for determining the efficacy of an agent or drug intended to decrease or inhibit a collagenase enzyme is disclosed.