CAS: 38875-53-5; 5-Bromo-2,3-Diaminopyridine

相似化合物

6945-68-2 433226-05-2 166047-15-0

上下游产品

CAS号6945-68-2 2-氨基-5-溴-3-硝基吡啶 | CAS号7440-44-0 活性炭 | CAS号1003711-13-4 6-氨基-5-硝基-3-吡啶甲腈 | CAS号42869-47-6 6-溴-2-甲基- 4-氮杂苯并咪唑 | CAS号452-58-4 2,3-二氨基吡啶 | CAS号28279-49-4 6-溴-4氢-咪唑并[4,5-B]吡啶 | CAS号52333-42-3 7-溴吡啶并[2,3-b]吡嗪 | CAS号68175-12-2 6-溴-2-乙基-3H-咪唑并... | CAS号65147-89-9 6-溴-2-苯基-1h-咪唑并... | CAS号676371-00-9 6-溴咪唑[1,2-A]吡啶-8-胺 | CAS号128102-80-7 2-甲基吡啶并[2,3-b]吡... | CAS号1021919-65-2 6-溴-2-氧代-1H-咪唑并... | CAS号120889-04-5 2-羟基-1-甲基-6-苯基咪...

6-氨基-5-硝基-3-吡啶甲腈置于palladium On Activated Charcoal 氢气体系中,用 乙醇 用作溶剂,化学反应生成2,3-二氨基-5-溴吡啶
参考文献:Methods For Chk2 Inhibitor Patient Selection
标题:Methods For Chk2 Inhibitor Patient Selection
摘要:本发明考虑了一种用于识别患有肿瘤或患有肿瘤风险,对激活的chk2蛋白的各种抑制剂具有响应的受试者的方法.这些chk2抑制剂可能包括苯并咪唑核结构及其衍生物.其他chk2抑制剂可能包括核酸,例如特异于chk2表达的沉默干扰rna.其他chk2抑制剂可能包括蛋白质,例如抗体.例如,本发明考虑了当在电离辐射期间或之后给予chk2抑制剂时,肿瘤细胞凋亡增加.

专利信息

专利号:US-9708317-B2
优先权日:2013-11-25
标 题 :Process for the preparation of 8-(4-aminophenoxy)-4H-pyrido[2,3-B]pyrazin-3-one derivatives
发明人：ZAMBON ALFONSO; NICULESCU-DUVAZ DAN; CHUBB RICHARD; SPRINGER CAROLINE JOY
权利人:CANCER RES TECH LTD; INST OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE); OXY SCIENT LTD; THE INST OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
摘要:The present invention pertains generally to the field of organic chemical synthesis, and in particular to certain methods for the synthesis of 8-(4-aminophenyoxy)-4H-pyrido[2,3-b]pyrazin-3-one and related compounds (denoted herein as (3)) from 4-(4-aminophenyoxy)pyridine-2,3-diamine and related compounds (denoted herein as (1)), by reaction with glyoxylic acid (denoted herein as (2)). The compounds (3) are useful in the synthesis of known anti-cancer agents, such as 1-(5-tert-butyl-2-(4-methyl-phenyl)-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea.

专利号:WO-2025061707-A1
优先权日:2023-09-19
标题:Synthesis of sulfoximines containing a benzimidazole moiety
发明人：SMITS HELMARS; DUMEUNIER RAPHAEL; PERROTTA DANIELE
权利人:SYNGENTA CROP PROTECTION AG
摘要:A process for the preparation of enantiomerically enriched sulfoximines of formula (I) is provided, wherein R1, R2, S*, R3, R4, X and X2 are as defined in the description.

专利号:WO-2024233563-A1
优先权日:2023-05-09
标 题:6,6-fused bicyclic amides and compositions for use as 15-prostaglandin dehydrogenase modulators
发明人：GREENMAN KEVIN LLOYD; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; AMEGADZIE ALBERT K; BOURBEAU MATTHEW P; LI KEXUE
权利人:AMGEN INC
摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a structure of Formula (I): or a pharmaceutically acceptable salt thereof; wherein is Formula (i) or Formula (ii) Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:US-2011021532-A1
优先权日:2008-04-22
标题 :Novel substituted heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：POWELL DAVID; LEBRUN MARIE-EVE; BHAT SATHESH; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Substituted heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).

专利号:RU-2193036-C2
优先权日:1997-02-25
标 题:Derivatives of imidazo[1,2-a]pyridine, methods of their synthesis, pharmaceutical preparation based on thereof, method of inhibition of gastric acid secretion, method of treatment of gastroenteric inflammatory diseases and method of treatment of states with helicobacter pylori infection