CAS: 51293-47-1; Boc-Ser(Me)-Oh

相似化合物

86123-95-7 19794-53-7 3262-72-4

上下游产品

CAS号3262-72-4 B°C-L-丝氨酸 | CAS号74-88-4 碘甲烷 | CAS号4219-94-7 O-甲基DL-丝氨酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号2766-43-0 B°C-L-丝氨酸甲酯

Boc-L-丝氨酸甲酯置于sodium Hydroxide,Proton Sponge体系中,用 甲醇 作为反应溶剂,化学反应生成 保护的甲基-L-丝氨酸二环己基铵盐
参考文献:Synthetic Studies Towards Keramamide F
标题:Synthetic Studies Towards Keramamide F
摘要:This Communication Describes The Synthesis Of Three Fragments Of The Cytotoxic Natural Product Keramamide F.
DOI:10.1016/0040-4039(94)02213-U

专利信息

专利号:US-5811515-A
优先权日:1995-06-12
标 题 :Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis
发明人：GRUBBS ROBERT H; MILLER SCOTT J; BLACKWELL HELEN E
权利人:CALIFORNIA INST OF TECHN
摘要:A method for synthesizing conformationally restricted amino acids, peptides, and peptidomimetics by ring closing metathesis. The method includes the steps of synthesizing a peptide precursor containing first and second unsaturated C--C bonds and contacting the peptide precursor with a RCM catalyst to yield a conformationally restricted peptide. Suitable peptide precursors may contain two or more unsaturated C--C bonds. These bonds may be olefinic bonds and may be contained in first and second alkenyl groups which may be allyl groups. The RCM catalyst may be a Ruthenium or Osmium carbene complex catalyst and more specifically, a Ruthenium or Osmium carbene complex catalyst that includes a Ruthenium or Osmium metal center that is in a +2 oxidation state, has an electron count of 16, and is pentacoordinated. The method may be carried out using solid-phase-peptide-synthesis techniques. In this embodiment, the precursor, which is anchored to a solid support, is contacted with a RCM catalyst and the product is then cleaved from the solid support to yield a conformationally restricted peptide.

专利号:WO-9726002-A1
优先权日:1996-01-17
标 题:Synthesis of conformationally restricted amino acids, peptides and peptidomimetics by catalytic ring closing metathesis
发明人：GRUBBS ROBERT H; MILLER J SCOTT; BLACKWELL HELEN E
权利人:CALIFORNIA INST OF TECHN
摘要:A method for synthesizing conformationally restricted amino acids, peptides, and peptidomimetics by ring closing metathesis. The method includes the steps of synthesizing a peptide precursor containing first and second unsaturated C-C bonds and contacting the peptide precursor with an RCM catalyst to yield a conformationally restricted peptide. Suitable peptide precursors may contain two or more unsaturated C-C bonds. These bonds may be olefinic bonds and may be contained in first and second alkenyl groups which may be allyl groups. The RCM catalyst may be a Ruthenium or Osmium carbene complex catalyst and more specifically, a Ruthenium or Osmium carbene complex catalyst that includes a Ruthenium or Osmium metal center that is in a +2 oxidation state, has an electron count of 16, and is pentacoordinated. The method may be carried out using solid-phase-peptide-synthesis techniques. In this embodiment, the precursor, which is anchored to a solid support, is contacted with an RCM catalyst and the product is then cleaved from the solid support to yield a conformationally restricted peptide.

专利号:US-5451691-A
优先权日:1992-05-07
标题 :Synthesis of cosmetic ingredients
发明人：CRAWFORD DUNCAN J; RAWLINGS ANTHONY V; SCOTT IAN R
权利人:ARDEN ELIZABETH CO
摘要:A method of synthesis of ω-hydroxy fatty acid containing ceramides having the general structure (1). ##STR1## where A represents CH 2 or --CHâ•?CH--Y represents a residue of a C 14 to C 22 fatty acid having the structure (2) ##STR2## where Z is --OH or an epoxy oxygen n x is an integer of from 12 to 20 n y is an integer of from 20 to 40 n z is 0 or an integer of from 1 to 4 n a is an integer of from 8 to 50 n b is an integer of from 10 to 100 n and n is an integer of from 7 to 27.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-7629488-B2
优先权日:2005-03-14
标 题 :Process for the preparation of opioid modulators
发明人：CAI CHAOZHONG; HE WEI
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to novel processes for the preparation of opioid modulators (agonists and antagonists) and intermediates in their synthesis. The opioid modulators are useful for the treatment and prevention of as pain and gastrointestinal disorders.

专利号:US-2008045718-A1
优先权日:2006-08-14
标题 :Process and intermediates for the synthesis of 2-(quinolin-5-yl)-4,5 disubstituted-azole derivatives