CAS: 53-79-2; (S)-2-Amino-N-((2S,3S,4R,5R)-5-(6-(Dimethylamino)-9H-Purin-9-yl)-4-Hydroxy-2-(Hydroxymethyl)Tetrahydrofuran-3-yl)-3-(4-Methoxyphenyl)Propanamide

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CAS号57182-86-2 3'-[(N-benzylox... | CAS号57183-05-8 3'-[(N-tert-but... | CAS号67313-10-4 2-(6-AMINO-9H-P... | CAS号2627-64-7 2′,3′-Anhydroad... | CAS号125084-71-1 9-[3-(benzylami... | CAS号58-60-6 维生素E醋酸酯

N-苄氧羰基-L-酪氨酸置于palladium On Activated Charcoal 氢气,双(2-氧代-3-恶唑烷基)次磷酰氯,Sodium Hydride,N,N-二异丙基乙胺体系中,用 四氢呋喃,乙醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 8.0H,反应生成 嘌呤霉素
参考文献:6-二甲氨基-9-[3-(O-甲基) (2S)-[ul-14C]-酪氨酰氨基)-3-脱氧--D-呋喃核糖基]嘌呤的合成
标题:6-二甲氨基-9-[3-(O-甲基) (2S)-[ul-14C]-酪氨酰氨基)-3-脱氧--D-呋喃核糖基]嘌呤的合成
摘要:为了研究和进一步完善口蹄疫病毒 (Fmdv) 18 个氨基酸 2A 区独特切割活性的机制,需要合成 14C 标记的嘌呤霉素.puromycin 是一种蛋白质合成抑制剂,是氨酰-Trna 末端氨酰-腺苷部分的类似物.6-二甲氨基-9-[3'-([[o-甲基) (2S)-[ul-14C]-酪氨酰氨基)-3'-脱氧-β-D-呋喃核糖基]嘌呤的短而方便的四步合成因此描述了从 (2S)-[ul-14C]-酪氨酸开始的(14C 标记的嘌呤霉素).版权所有 © 2000 John Wiley & Sons,Ltd.
DOI:10.1002/(Sici)1099-1344(200005)43:6<623::Aid-Jlcr347>3.0.Co;2-O

专利信息

专利号:US-7041446-B2
优先权日:1998-05-15
标 题 :Labeled protein and its producing method, labeling compound to be used in the method, and method for analyzing function of genes
发明人：YANAGAWA HIROSHI; NEMOTO NAOTO; MIYAMOTO ETSUKO
权利人:MITSUBISHI CHEM CORP
摘要:A protein having a labeling compound attached to its C-terminal, in which the compound comprises a label portion comprising a label substance and an acceptor portion comprising a compound having an ability of binding to a C-terminal of a synthesized protein when protein synthesis is carried out in a cell-free protein synthesis system or in a living cell is provided. Also, a method for producing the protein comprising the step of performing synthesis of a protein in a cell-free protein synthesis system or in a living cell in the presence of a labeling compound comprising a label portion comprising a label substance and an acceptor portion comprising a compound having an ability of binding to a C-terminal of a synthesized protein when protein synthesis is carried out in the cell-free protein synthesis system or in the living cell, the labeling compound being present at a concentration effective for the labeling compound to bind to the C-terminal of the synthesized protein is provided. Also, the labeling compound and a method for analyzing a function of a gene are further provided.

专利号:US-2024124910-A1
优先权日:2021-02-02
标题:Ribosome-mediated polymerization of novel chemistries
发明人：JEWETT MICHAEL CHRISTOPHER; LEE JOONGOO; ANSLYN ERIC V; CORONADO JAIME; LIM JONGDOO
权利人:UNIV NORTHWESTERN; UNIV TEXAS
摘要:Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

专利号:US-2007065922-A1
优先权日:2005-09-21
标题 :Biocatalytic synthesis of aminodeoxy purine N9-beta-D-nucleosides containing 3-amino-3-deoxy-beta-D-ribofuranose, 3-amino-2,3-dideoxy-beta-D-ribofuranose, and 2-amino-2-deoxy-beta-D-ribofuranose as sugar moieties
发明人：BARAI VLADIMIR N; EROSHEVSKAYA LUDMILLA A; MIKHAILOPULO IGOR A; AZHAYEV ALEX V; LAPINJOKI SEPPO P
权利人:METKINEN OY
摘要:Purine N 9 -β-D-nucleosides containing 3-amino-3-deoxy-β-D-ribofaranose, 3-amino-2,3-dideoxy-β-D-ribofuranose, and 2-amino-2-deoxy-β-D-ribofuranose as sugar moieties are synthesized by biocatalytic transglycosylation of purine bases and the respective 3′-amino-3′-deoxyuridine, 3′-amino-3′-deoxythymidine and 2′-amino-2′-deoxyuridine as donors of the carbohydrate moiety, and the cells of Escherichia coli as a biocatalyst or glutaraldehyde (GA) treated cells of Escherichia coli as a biocatalyst or a mixture of thymidine (uridine) phosphorylase and purine nucleoside phosphorylase.

专利号:US-8734846-B2
优先权日:2008-06-16
标 题 :Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles
发明人：ALI MIR M; HRKACH JEFF; ZALE STEPHEN E; ALVAREZ DE CIENFUEGOS LUIS
权利人:BIND BIOSCIENCES INC
摘要:This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly (ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization fromâ€? approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a “coupling toâ€? that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses “orthogonalâ€? chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.

专利号:US-2006057069-A1
优先权日:2004-06-07
标 题 :Detection of protein expression in vivo using fluorescent puromycin conjugates
发明人：STARCK-GREEN SHELLEY R; GREEN HARRY M; ALBEROLA-ILA JOSE; ROBERTS RICHARD W; SCHUMAN ERIN; SMITH WILLIAM B; HAY BRUCE A
权利人:CALIFORNIA INST OF TECHN
摘要:Disclosed is a class of reagents for examining protein expression in vivo that does not require transfection, radiolabeling, or the prior choice of a candidate gene. Further, a series of puromycin conjugates was constructed bearing various labeling moieties. These conjugates were readily incorporated into expressed protein products in cell lysates in vitro and efficiently cross cell membranes to function in protein synthesis in vivo as indicated by flow cytometry, selective enrichment studies, and western analysis. The present invention demonstrates that labeled-puromycin conjugates offer a general means to examine protein expression in vivo.

专利号:US-2010247433-A1
优先权日:2005-10-14
标题:Use of non-canonical amino acids as metabolic markers for rapidly-dividing cells
发明人：TIRRELL DAVID; DIETERICH DANIELA C; LINK AARON J; SCHUMAN ERIN
权利人:CALIFORNIA INST OF TECHN
摘要:The invention provides methods, reagents and systems to preferentially mark fast-proliferating cells/tissues (such as cancer), by incorporating non-natural amino acids into proteins, preferably in vivo, using the endogenous protein synthesis machinery of an organism. The incorporated non-natural amino acids contain reactive groups for further chemical reagents, which may serve as a “handleâ€? to for a number of uses, such as imaging of cancer cells, targeting drugs to preferentially kill cancer cells, and proteomic analysis in the context of large scale or high throughput screening for candidate drug leads that affects the proliferation of a target cell, etc.