CAS: 5399-92-8; 4-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine

相似化合物

42754-96-1 1082950-96-6 943324-22-9

上下游产品

Allopurinol 4-hydroxypyrazolo(3,4-d)pyrimidine 2,6-dichloro-pyrimidine carbaldehyde hydrazine hydr°Chloride (2)H-pyrazolo[3,4-d]pyrimidin-4-yl)-amine(3-methyl-butyl)-(1(2)H-pyrazolo[3,4-d]pyrimidin-4-yl)-amine (2)H-pyrazolo[3,4-d]pyrimidin-4-yl)-amineethyl-propyl-(1(2)H-pyrazolo[3,4-d]pyrimidin-4-yl)-amine (2)H-pyrazolo[3,4-d]pyrimidine4-ethoxy-1(2)H-pyrazolo[3,4-d]pyrimidine (2)H-pyrazolo[3,4-d]pyrimidin-4-yl)-amineisopropyl-(1(2)H-pyrazolo[3,4-d]pyrimidin-4-yl)-amine

别嘌醇置于三氯氧磷体系中,化学反应生成 4-氯-1H-吡唑并[3,4-D]嘧啶
参考文献:Structure-metabolism Relationships In Human-Aox: Chemical Insights From A Large Database Of Aza-Aromatic And Amide Compounds
标题:Structure-metabolism Relationships In Human-Aox: Chemical Insights From A Large Database Of Aza-Aromatic And Amide Compounds
摘要:<意义> 代谢异物是药物发现的关键方面;如今,醛氧化酶(Aox)已经成为一个关键的代谢酶,在几个临床候选药物失败中发挥了关键作用.关于该酶可能底物和非底物的数据不一致性,限制了发展一个用于代谢预测的计算模型.在这里,我们提供了一个包含270种化学结构多样的化合物数据库,其中包含易受人类aox影响的氮杂芳香族和/或酰胺基团,经过体外实验测试.这里报告的结果应该对开发可靠的预测模型有所帮助,这对化学,生物学,生物技术和医学领域都具有广泛的兴趣.
DOI:10.1073/pnas.1618881114

专利信息

专利号:US-2013296346-A1
优先权日:2010-11-23
标题 :Diphenyl-amine derivatives: uses, process of synthesis and pharmaceutical compositions
发明人：RODES SOLANES ROSA; GARCIA DOMINGUEZ NEFTALI; LOPEZ ORTEGA BEATRIZ; ALVAREZ DE MON SOTO MELCHOR; DE LA HERA MARTINEZ ANTONIO; MUNOZ MUNOZ ANA; LEDO GOMEZ FRANCISCO
权利人:RODES SOLANES ROSA; GARCIA DOMINGUEZ NEFTALI; LOPEZ ORTEGA BEATRIZ; ALVAREZ DE MON SOTO MELCHOR; DE LA HERA MARTINEZ ANTONIO; MUNOZ MUNOZ ANA; LEDO GOMEZ FRANCISCO; FAES FARMA SA
摘要:The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, a method of synthesis of said compounds, pharmaceutical compositions comprising them and their use as a medicament for treating inflammatory diseases.

专利号:US-11020399-B2
优先权日:2011-05-04
标 题:Intermediates useful in the synthesis of compounds as modulators of protein kinases

专利号:CN-111848419-A
优先权日:2020-07-28
标 题 :(E) Synthesis method of -4-hydroxy-3-methyl-2-butenylamine and zeatin

专利号:CN-111848419-B
优先权日:2020-07-28
标 题:(E) Synthesis method of (E) -4-hydroxy-3-methyl-2-butenylamine and zeatin

专利号:EP-2465498-A1
优先权日:2010-11-23
标题 :Diphenyl-amine derivatives: uses, process of synthesis and pharmaceutical compositions

专利号:AU-2011333887-A1
优先权日:2010-11-23
标 题 :Diphenyl-amine derivatives: uses, process of synthesis and pharmaceutical compositions