CAS: 5440-00-6; 5,6-Diamino-1,3-Dimethylpyrimidine-2,4(1H,3H)-Dione

相似化合物

6972-82-3 6632-68-4 200335-70-2

上下游产品

CAS号6632-68-4 1,3-二甲基-6-亚氨基-5... | CAS号6642-31-5 1,3-二甲基-6-氨基脲嘧啶 | CAS号3346-61-0 6-amino-1,3-dim... | CAS号17743-04-3 dihydro-6-imino... | CAS号769-42-6 1,3-二甲基巴比妥酸 | CAS号6972-27-6 6-氯-1,3-二甲基尿嘧啶 | CAS号1203-25-4 2,4(1H,3H)-Pyri... | CAS号7597-60-6 6-氨基-1,3-二甲基-5-... | CAS号10184-41-5 5-acetylamino-6... | CAS号109418-98-6 Pentanoic acid,... | CAS号35873-49-5 A1受体拮抗剂,CPT | CAS号147700-16-1 8-[2-(2,3-dimet... | CAS号14320-99-1 4,6-dimethyl-2-... | CAS号944-73-0 1,3-二甲基尿酸 | CAS号961-45-5 8-苯基茶碱 | CAS号94-41-7 苯亚甲基苯乙酮 | CAS号2850-40-0 1H-Purine-2,6-d... | CAS号25477-76-3 2,4(1H,3H)-Pter... | CAS号2625-25-4 2,4(1H,3H)-Pter...

6-氨基-5-甲酰氨基-1,3-二甲基尿嘧啶置于盐酸,甲醇体系中,化学反应生成 5,6-二氨基-1,3-二甲基脲嘧啶
参考文献:Bredereck; Edenhofer,Chemische Berichte,1955,Vol. 88,P. 1306,1309
标题:Bredereck; Edenhofer,Chemische Berichte,1955,Vol. 88,P. 1306,1309

专利信息

专利号:US-7060818-B2
优先权日:2003-02-21
标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
发明人：HORWITZ COLIN P; GHOSH ANINDYA
权利人:UNIV CARNEGIE MELLON
摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.

专利号:US-4696932-A
优先权日:1984-10-26
标题 :Biologically-active xanthine derivatives
发明人：JACOBSON KENNETH A; DALY JOHN W; KIRK KENNETH L
权利人:US HEALTH
摘要:Certain functionalized cogeners of 1,3-dialkylxanthine exhibit high potency and selectivity as antagonists for A 1 - and A 2 -adenosine receptors and are suitable for attachment to probes, drug carriers, or solid supports. These derivatives are characterized by the presence of a phenyl at the 8 position para-substituted with a functionalized chain to provide high water solubility and high receptor affinity. Some of these analogs, containing a distal amino- or carboxylic-functionalized chain, are suitable for synthesis of amino acid conjugates. The compounds of this invention are suitable for use as antiallergenic, antiasthmatic, or cardiotonic drugs, central nervous system stimulants, and diuretics.

专利号:US-4355165-A
优先权日:1978-07-24
标题 :Amino-functionalized phthalhydrazide intermediates
发明人：BOGUSLASKI ROBERT C; CARRICO ROBERT J; CHRISTNER JAMES E
权利人:MILES LAB
摘要:Amino-functionalized phthalhydrazide intermediates of the formula: ##STR1## wherein one of R 5 and R 6 is hydrogen and the other is --NR 7 R 8 ; R 7 is hydrogen or straight chain alkyl containing 1-4 carbon atoms and R 8 is ##STR2## wherein n=1-3. The compounds are intermediates in the synthesis of chemiluminescent-labeled conjugates which are useful as reagents in specific binding assays for determining ligands or their specific binding partners in liquid media.

专利号:US-4363759-A
优先权日:1978-04-10
标题 :Chemiluminescent-labeled haptens and antigens
发明人：BOGUSLASKI ROBERT C; CARRICO ROBERT J; CHRISTNER JAMES E
权利人:MILES LAB
摘要:Chemiluminescent-labeled conjugates of the formula: wherein one of R1 and R2 is hydrogen and the other is -NR3R4; R3 is hydrogen or straight chain alkyl containing 1-4 carbon atoms and R4 is wherein n=1-3 and L(CO- is the ligand or analog bound through an amide bond. Intermediates produced in the synthesis of such conjugates are also disclosed.

专利号:US-4226993-A
优先权日:1978-07-24
标题:Amino-functionalized phthalhydrazides
发明人：BUCKLER ROBERT T; SCHROEDER HARTMUT R
权利人:MILES LAB
摘要:Amino-functionalized phthalhydrazides of the formula: ##STR1## wherein one of R 5 and R 6 is hydrogen and the other is --NR 7 R 8 ; R 7 is hydrogen or straight chain alkyl containing 1-4 carbon atoms and R 8 is n n H.sub.2 N--CH.sub.2).sub.n n n wherein n=2-8. The compounds are intermediates in the synthesis of chemiluminescent phthalhydrazide-labeled conjugates which are useful as reagents in specific binding assays for determining ligands or their specific binding partners in liquid media.

专利号:US-2025082601-A1
优先权日:2023-09-08
标题:Significantly non-toxic novel Cobalt(III) Schiff base complex induces apoptosis via G2-M cell cycle arrest in human breast cancer cell line MCF-7 and cell cycle arrest of colon cancer cell lines HCT-116 and SW- 480 via G0-G1
发明人：DASGUPTA SANCHARI; KAR KANISHA PAL; BARUA ATISH; GHOSH DIYA; KABI BIKASH; DEWAN KOUSHIK; CHANDRA ARPITA; BHAR SUNANDITA; DAS TANIMA
权利人:CHITTARANJAN NAT CANCER INSTITUTE
摘要:A significantly non-toxic novel mononuclear cobalt(III)-Schiff base complex (1) capable to induce apoptosis via G2-M cell cycle arrest in human breast cancer cell line MCF-7 and cell cycle arrest of colon cancer cell lines HCT-116 and SW-480 via G0-G1. The Schiff base complex (1) having >99% purity has been synthesized by a facile “One potâ€? synthesis method and has been characterized with standard spectroscopic techniques. Complex 1 exhibits cytotoxicity (IC50=16.81±1.33 μM) at much lower concentration in comparison to oxaliplatin (IC50=31.4±0.69 μM) against MCF-7 cells and causes apoptosis in colon cancer cell lines HCT-116 and SW-480 by arresting the cell cycle at the G0-G1 phase having IC50 values of 15.27±1.18 μM and 10.04±1.98 μM respectively comparable with the IC50 values of oxaliplatin which are 16.73±1.78 μM and 7.87±1.54 μM respectively after 24 h of treatment without being overly toxic to human PBMCs (IC50=>60 μM). In vivo subacute toxicity (28 days) and systemic chronic toxicity (40 days) studies were carried out in normal Swiss albino mice showed 1 is sinificantly nontoxic to the host.