CAS: 556-48-9; Cyclohexane-1,4-Diol

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1,4-环己二酮置于sodium Tetrahydroborate体系中,化学反应生成 1,4-环己二醇
参考文献:C 5-姜黄素的新型簇 :设计,合成,体外抗增殖活性和基于4-羟基环己酮支架的双(亚芳基)-4-环酮衍生物的dna结合
标题:C 5-姜黄素的新型簇 :设计,合成,体外抗增殖活性和基于4-羟基环己酮支架的双(亚芳基)-4-环酮衍生物的dna结合
摘要:本文描述了一个新的系列(6)c 5-姜黄素衍生物(2 E,6 E-2,2,6-二亚苄基-4-羟基环己酮),并对其体外抗增殖活性进行了评估.进行了针对人a2780(卵巢),C33A(子宫颈)和mda-Mb-231(乳腺癌)癌细胞系的31种化合物的评估,以获得结构活性相关数据.表现最佳的是(2 E,6 E)-2,6-双(3'-硝基亚苄基)-4-羟基环己酮(6H),Ic 50分别为1.30μm,3.69μm和19.13μm的顺铂,分别为0.68μm(a2780),0.69μm(c33A)和0.92μm(mda-Mb-231).根据计算的理化性质,第 6列中的 某些成员,即(2 E,6 E)-2,6-双[(4'-吡啶基)亚甲基]-4-羟基环己酮(6P)[ic 50 = 0.76μm(a2780),2.69μm(c33A),1.28μm(mda-Mb-231)]与姜黄素相比似乎具有更高的生物利用度.系列
DOI:10.1007/s11164-019-03859-4

专利信息

专利号:US-4229364-A
优先权日:1979-05-14
标 题:Synthesis of 1,4-bis(dicyanomethylene) cyclohexane
发明人：CRAWFORD ROBERT J
权利人:PROCTER & GAMBLE
摘要:1,4-Bis(dicyanomethylene)cyclohexane is the chemical of choice for the synthesis of TCNQ. The present invention provides a simple convenient, three-step synthesis of 1,4-bis(dicyanomethylene)cyclohexane from hydroquinone which uses water as the reaction solvent.

专利号:EP-0309324-B1
优先权日:1987-09-17
标 题:Process for the preparation of n-alkylated amino acids and their esters, use in the synthesis of carboxyalkyl dipeptides
摘要:Process for industrial synthesis of the derivative of formula (I): and their addition salts with an inorganic or organic acid or base, in which: R1 is linear or branched lower alkyl (of 1 to 6 carbon atoms), R2 is hydrogen or a linear or branched lower alkyl group (of 1 to 4 carbon atoms). Application to the industrial synthesis of carboxyalkyl dipeptides.

专利号:US-2024368099-A1
优先权日:2022-01-18
标 题:Methods for the synthesis of di(hydroxymethyl)tetrahydrofuran and its application in polyesters and polyurethanes
发明人：SPIEGELBERG BRIAN; BRANDT ADRIAN; BECK HORST; KUX ALEXANDER; TIN SERGEY; DE VRIES JOHANNES GERARDUS
权利人:HENKEL AG & CO KGAA
摘要:The present invention relates to the synthesis of di(hydroxymethyl)tetrahydrofuran (DHMTHF) and the preparation of trans-enriched mixtures of DHMTHF. The invention further refers to polyester polyols which are obtained by reaction of cis/trans DHMTHF mixtures with a dicarboxylic acid. The invention further relates to polyurethanes and compositions containing a polyester polyol comprising DHMTHF, in particular to such polyurethane-containing (adhesive) compositions.

专利号:US-4472568-A
优先权日:1981-11-12
标 题:Process for the preparation of polyamines from N-monoaryl-N',N'-dialkyl urea compounds and their use for the synthesis of polyurethanes
发明人：RASSHOFER WERNER; GROEGLER GERHARD
权利人:BAYER AG
摘要:This invention relates to an improved process for the preparation of aromatic polyamines containing urethane and/or biuret and/or urea and/or isocyanurate groups and preferably also ether groups by the hydrolysis of poly-N-monoaryl-N',N'-dialkyl urea compounds (1-aryl-3,3-dialkyl ureas). The ureas are obtained by the reaction of secondary aliphatic, cycloaliphatic or saturated heterocyclic amines with divalent to tetravalent isocyanate compounds containing isocyanate end groups attached to aromatic residues. The ureas correspond to the general formula: wherein R1, R2 denote alkyl or cycloalkyl groups, or together form a ring and A denotes a divalent to tetravalent residue attached to the ureas by aromatic groups. Hydrolysis is carried out in the presence of water and up to two equivalents of a base containing hydroxide ions and/or up to two equivalents of a compound containing tertiary amino groups, optionally in the presence of solvents. The use of the polyamines obtained by this process for the synthesis of polyurethanes is also described.

专利号:US-10730994-B2
优先权日:2015-06-08
标 题:Synthesis of polycarbonate siloxane diols
发明人：MAGUIRE FRANCIS P; VENKATARAMANI SRIRAM
权利人:AORTECH INT PLC; MAGUIRE FRANCIS P; VENKATARAMANI SRIRAM
摘要:The present invention provides silicon-based polycarbonates, processes for their preparation and their use in the synthesis of copolymers, in particular segmented copolymers such as polyurethanes for biomedical applications.

专利号:EP-0909792-B1
优先权日:1997-10-15
标 题:Storage-stable composition for the synthesis of polyurethanes
发明人：BAUMANN EDWIN; HAEBERLE KARL DR; HORN PETER DR; TREULING ULRICH DR; SCHWAEBISCH HANS
权利人:BASF AG
摘要:Polyurethane synthesis composition using a polymeric emulsifier having a backbone consisting of a copolymer of 4-12C unsaturated dicarboxylic acid or anhydrides and 2-40C olefins, with polyoxyalkylene side chains derived from 2-20C oxiranes. A polyurethane (PU) synthesis composition containing, as emulsifier, a polymer (T) with (at least) a copolymer backbone (TR) derived from 4-12 carbon(C) unsaturated dicarboxylic acid(s) and/or their anhydrides (TR1) and 2-40 C olefin(s) (TR2), and having polyalkylene oxide side chain (TP) derived from 2-20 C oxirane(s) (TP1), together with at least two compounds (a) comprising at least two reactive hydrogen atoms, at least one of which is insoluble. Independent claims are also included for: (a) a process for the production of synthesis composition by contacting the components in presence of a polymer; (b) a PU synthesis composition obtained; (c) a polyurethane obtained by bringing the synthesis composition into contact with a polyisocyanate; and (d) moldings, fibers, coatings, paint, sheets and a foam made from the PU compositions.