CAS: 626-43-7; 3,5-Dichloroaniline

上下游产品

CAS号39943-56-1 3,5-二氯苯肼 | CAS号634-83-3 2,3,4,5-四氯苯胺 | CAS号108-95-2 苯酚 | CAS号117-18-0 四氯硝基苯 | CAS号618-62-2 3,5-二氯硝基苯 | CAS号18487-39-3 2,3,5-三氯苯胺 | CAS号7440-05-3 钯 | CAS号19752-55-7 3,5-二氯-1-溴苯 | CAS号634-91-3 3,4,5-三氯苯胺 | CAS号1228378-57-1 2-azido-N-(3,5-... | CAS号34883-41-5 3,5-二氯联苯 | CAS号41464-42-0 2,3',5,5'四氯联苯 | CAS号33560-48-4 乙酰苯胺,2,3',5'-三氯- | CAS号527-20-8 五氯苯胺 | CAS号34893-92-0 3,5-二氯苯异氰酸酯 | CAS号57339-11-4 2-溴-N-(3,5-二氯苯基)乙酰胺 | CAS号4964-77-6 5,7-二氯喹啉 | CAS号33719-74-3 3,5-二氯苯甲醚 | CAS号144989-41-3 4,6-二氯-2-(乙氧基羰基... | CAS号143294-51-3 3-(4-aminopheny...

3,5-二氯-1-溴苯置于dicyclohexyl(2',4',6'-Triisopropyl-5-Methoxy-3,4,6-Trimethyl-[1,1'-Biphenyl]-2-yl)Phosphine,C50H70No4Ppds,,Dicyclohexyl(2',4',6'-Triisopropyl-4-Methoxy-3,5,6-Trimethyl-[1,1'-Biphenyl]-2-yl)Phosphine,氨,Sodium T-Butanolate体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 24.0H,以48%的收率获得产物3,5-二氯苯胺
参考文献:使用大块双芳基膦配体和钯环预催化剂实现温和且高选择性的钯催化氨单芳基化
标题:使用大块双芳基膦配体和钯环预催化剂实现温和且高选择性的钯催化氨单芳基化
摘要:描述了一种 Pd 催化的氨与多种芳基和杂芳基卤化物的芳基化方法,包括具有挑战性的五元杂环底物.通过使用庞大的联芳膦配体(l6,L7和l4)及其相应的氨基联苯钯环预催化剂(3A,3B和3C),在温和条件下或在室温下实现了将氨单芳基化成伯芳胺的出色选择性.由于该过程既不需要使用手套箱,也不需要高压氨,因此应广泛适用.
DOI:10.1021/ol401612C

专利信息

专利号:US-4264775-A
优先权日:1976-10-27
标 题:Synthesis of β-aminostyrenes
发明人：WHITE WILLIAM A
权利人:LILLY CO ELI
摘要:A simple process for the preparation of beta -aminostyrenes proceeds from anilines by successively diazotizing, reacting with a vinyl ester, and reacting with a secondary amine without purification of the intermediate products. The compounds are reactive enamines useful in organic synthesis.

专利号:US-9968612-B2
优先权日:2012-09-17
标题:Method of synthesizing thyroid hormone analogs and polymorphs thereof
发明人：TAUB REBECCA; REYNOLDS CHARLES H
权利人:MADRIGAL PHARMACEUTICALS INC
摘要:The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TRβ mutation.

专利号:US-6465653-B2
优先权日:1998-09-29
标题:Noncatalyzed synthesis of 4-hydroxyquinolines and/or tautomers thereof
发明人：DANG TAUN-PHAT; ROUSTAN ALAIN
权利人:RHODIA CHIMIE SA
摘要:The 4-hydroxyquinoline compounds and/or tautomers thereof, notably 4-hydroxy-5,7-dichchloroquinoline, are synthesized in very high yields by hydrolyzing/decarboxylating a 4-hydroxyquinolinecarboxylic acid ester in the presence of water, whether in liquid or vapor state, but in the absence of any catalyst for such reaction(s).

专利号:US-2007173517-A1
优先权日:2006-01-20
标 题:Synthesis of 6,7-Dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
发明人：WIRTH THOMAS; KROEBER JUTTA; NICOLA THOMAS; RAPP ARMIN; GUTHEIL DIETER; ORLICH SIMONE A; WANG XIAO-JUN; KRISHNAMURTHY DHILEEPKUMAR
权利人:WIRTH THOMAS; KROEBER JUTTA; NICOLA THOMAS; RAPP ARMIN; GUTHEIL DIETER; ORLICH SIMONE A; WANG XIAO-JUN; KRISHNAMURTHY DHILEEPKUMAR
摘要:Disclosed is an improved multi-step process for preparing a compound of Formula I: n n nwherein R 1 to R 3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.

专利号:US-7470795-B2
优先权日:2004-07-27
标 题:Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
发明人：WANG XIAO-JUN; WIRTH THOMAS; NICOLA THOMAS; ZHANG LI; FRUTOS ROGELIO PEREZ; XU YIBO; KRISHNAMURTHY DHILEEPKUMAR; NUMMY LAURENCE JOHN; VARSOLONA RICHARD J; SENANAYAKE CHRIS HUGH; KROEBER JUTTA; REEVES DIANA
权利人:BOEHRINGER INGELHEIM PHARMA; BOEHRINGER INGELHEIM INT
摘要:Disclosed is a multi-step process for preparing a compound of Formula I: n nwherein R 1 to R 3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.

专利号:EP-1268409-B1
优先权日:2000-03-17
标 题 :Continuous process for the synthesis of aromatic urethanes
发明人：CESTI PIETRO; BOSETTI ALDO; BATTISTEL EZIO; CARLETTI VITTORIO; BIGNAZZI RENZO
权利人:DOW GLOBAL TECHNOLOGIES INC
摘要:Process for the preparation of aromatic urethanes consisting in reacting organic carbonates with aromatic amines in reactors operating in continuous, feeding a total quantity of aromatic amines in a percentage, with respect to the weight of the total mixture, ranging from 4 to 30, and maintening a low concentration of amine in the reactor.