CAS: 711-01-3; Methyl Adamantane-1-Carboxylate

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1-Adamantanecarboxylic Peracid 以 环己烷 作为反应溶剂,化学反应生成 1-金刚烷甲酸甲酯
参考文献:过酸反应的亲核研究人员
标题:过酸反应的亲核研究人员
摘要:过酸rc0 3H产生自由基r',其与过酸或与溶剂反应,得到醇roh和烃rh.自由基的亲核特性可以通过用感应基团取代带有奇数电子的碳或通过使用环状或双环自由基等封闭结构来改变自由基杂化来进行修饰.对于每个r,比率roh / Rh的测量建立了具有过酸oo键的r的反应性规模.这种反应性不依赖于自由基的稳定性,而是强烈依赖于亲核特性.一级自由基的反应性比二级自由基的要低,并且与叔级自由基的反应性要低得多.作为双环[2.2.1]庚基-1的桥头自由基不与过酸反应.这些结果被解释为表明带有电荷转移的过渡态(极性效应),过酸是亲电子的,自由基是亲核的.讨论了pmo理论.
DOI:10.1016/0040-4020(80)80056-1

专利信息

专利号:EP-2097079-B1
优先权日:2006-11-30
标题:Modulation of prostaglandin/cyclooxygenase metabolic pathways
发明人：WUELFERT ERNST
权利人:HUNTER FLEMING LTD
摘要:A variety of diseases and disorders associated with the metabolic pathways involved in the activities of cyclooxygenase and the synthesis of prostaglandins, for example type 2 diabetes mellitus and its sequelae, ischemic vascular diseases, pain associated with inflammation, inflammatory skin conditions, spinal cord injury, peripheral neuropathy, multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis, as well as various types of cancer may be treated or prevented by the use of an agent which selectively enhances production of 15-deoxy-prostaglandin J2. The compounds are 7-hydroxy-steroids or condensed indoles.

专利号:WO-2014057495-A1
优先权日:2012-10-11
标 题 :A process for industrial preparation of [(s)-n-tert butoxycarbonyl-3-hydroxy]adamantylglycine
发明人：ALLA VENKAT REDDY; ALLA RAGHU MITRA; DUBEY AJAY KUMAR; REDDY P RAMAKRISHNA
权利人:LEE PHARMA LTD; ALLA VENKAT REDDY; ALLA RAGHU MITRA; DUBEY AJAY KUMAR; REDDY P RAMAKRISHNA
摘要:A commercially viable process for industrial preparation of [(S)-n-tert butoxycarbonyl-3-hydroxy]adamantylglycine which is a key intermediate for saxagliptin synthesis and is represented by compound of Formula-VI. The compound-VI obtained by the process of present invention has more than 99.5% HPLC purity, not more than 0.15 % of dihydroxy impurity, not more than 0.05% of isomer impurity and not more than 0.1% of any unknown impurity. Formula (VI).

专利号:WO-2011098985-A1
优先权日:2010-02-15
标题 :Method for preparing adamantyl compounds
发明人：BURGOS ALAIN; NAVARRE LAURE
权利人:FINORGA; BURGOS ALAIN; NAVARRE LAURE
摘要:The invention relates to compounds of formula (Formula III) (III) and of formula (Formula (IV) (IV), to methods for producing said compounds, and to the use thereof in the synthesis of saxagliptin.

专利号:US-5827855-A
优先权日:1992-12-28
标题 :Hexahydronaphthalene ester derivatives their preparation and their therapeutic uses
发明人：KOGEN HIROSHI; ISHIHARA SADAO; KOGA TEIICHIRO; KITAZAWA EIICHI; SERIZAWA NOBUFUSA; HAMANO KIYOSHI
权利人:SANKYO CO
摘要:Compounds of formula (I): (I) wherein R1 represents a group of formula (II) or (III): (II) (III) R2 is alkyl, alkenyl or alkynyl; R3 and R4 are each hydrogen, alkyl, alkenyl or alkynyl; R5 is hydrogen or a carboxy-protecting group; Ra is a group of formula -OR6; R6 is hydrogen; R6a and R6b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulfonyl, halogenated alkanesulfonyl or arysulfonyl, and their salts and esters. Such compounds inhibit the synthesis of cholesterol, and can be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.

专利号:SU-596591-A1
优先权日:1974-08-05
标题 :Silyl esters of adamantane-1-carboxylic acids for synthesis of polyorganosiloxanes

专利号:US-2023095750-A1
优先权日:2019-12-12
标 题:Flow chemistry synthesis of isocyanates
发明人：BURKART MICHAEL D; PHUNG HAI THIEN AN
权利人:UNIV CALIFORNIA
摘要:The disclosure provides, inter alia, safe and environmentally-friendly methods, such as flow chemistry, to synthesize isocyanates, such as methylene diphenyl diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, and tetramethylxylene diisocyanate.