CAS: 76-38-0; Methoxyflurane

英文名称Methoxyflurane
中文名称2,2-二氯-1,1-二氟乙基甲基醚
IUPAC名称2,2-dichloro-1,1-difluoro-1-methoxyethane
其它别名Ether,2,2-dichloro-1,1-difluoroethyl methyl (6CI,8CI); 1,1-Dichloro-2,2-difluoro-2-methoxyethane; 2,2-Dichloro-1,1-difluoro-1-methoxyethane; 2,2-Dichloro-1,1-difluoroethyl methyl ether; Analgizer; Anecotan; Inhalan; Methoflurane; Methoxane; Methoxyfluran; Methoxyflurane; Methyl1,1-difluoro-2,2-dichloroethyl ether; Metofane; Metoxfluran; Metoxifluran; Penthrane; Pentran; Pentrane
CAS编号76-38-0
MFCD编号:MFCD00040144
EINECS号:200-956-0
FDA UNII编号:30905R8O7B
分子式:C3H4Cl2F2O
分子量:164.97
产品CID: 1755834
产品分类原料药 → 麻醉剂 → 全身麻醉剂

相似结构搜索
产品信息参考
InChIKey: RFKMCNOHBTXSMU-UHFFFAOYSA-N
InChI=1S/C3H4Cl2F2O/c1-8-3(6,7)2(4)5/h2H,1H3…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数2.0

MSDS等安全信息

GHS象形图
GHS符号GHS02 & GHS07;
注释: Flame & Exclamation mark
危险类别易燃液体类别3
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Warning(警告)
危险描述H226 |易燃液体和蒸气.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P210-P241-P308+P311
危险等级3
UN编号1993.0
危险品标志Xi
风险等级Irritant
包装等级III
安全声明23-24/25
危险类别码10

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

合成目标产物 Methoxyflurane 主要起始原料 1,1-Dichloro-2,2-Difluoroethylene And Sodium Methoxide
(文献来源)合成步骤主要原料 1,1-Dichloro-2,2-Difluoroethylene 和 Sodium Methoxide

甲醇,二氯三氟乙烷置于四甲基氢氧化铵体系中,用甲醇作为反应溶剂,化学反应 0.02H,以62.93%的收率获得产物甲氧氟烷
参考文献: Preparation Of Halogenated Alkoxyethane[fr] Préparation D'Un Alcoxyéthane Halogéné
标题: Preparation Of Halogenated Alkoxyethane[fr] Préparation D'Un Alcoxyéthane Halogéné
摘要:一种连续制备卤代烷氧乙烷的方法,其通式为xc1Hc-Cf2Or,其中x为-Cl或-F,Or为c1-4烷氧基,该方法包括引入在流动反应器中反应组分的步骤,所述反应组分包括(i)通式为xc1Hc-Cyf2的化合物,其中x和y各自独立地为-Cl或-F,(II)碱,以及(iii)c1-4烷醇,其中a)流动反应器包括一个或多个管状流动线,反应组分作为反应混合物流经其中,B)在卤代烷氧乙烷形成期间,碱形成在烷醇中可溶的盐,C)至少在反应组分混合时形成卤代烷氧乙烷,所形成的卤代烷氧乙烷从反应器出流作为反应物.

海关参考信息

2905590020-2-氯乙醇
2903120001-二氯甲烷
2909199090-其他醚及其衍生物
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详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-9616071-A1
优先权日:1994-11-21
标题:PROCESSES FOR THE SYNTHESIS OF 3'-SUBSTITUTED LEWISx COMPOUNDS
发明人：SRIVASTAVA OM; IPPOLITO ROBERT; SRIVASTAVA GEETA; SZWEDA ROMAN; OHUCHI TOSHIO
权利人:GLYCOMED INC; SRIVASTAVA OM; IPPOLITO ROBERT; SRIVASTAVA GEETA; SZWEDA ROMAN; OHUCHI TOSHIO
摘要:Disclosed are processes for the chemical synthesis of 3'-substituted Lewis-OR compounds where R is an aglycon of at least one carbon atom. One particular compound prepared by the processes of this invention is 8-methoxycarbonyl-octyl-2-acetamido-3-O-( alpha -L-fucopyranosyl)-4-O-[3-O-sulfo- beta -D-galactopyranosyl]-2-deoxy- beta -D-glucopyranoside.

专利号:EP-0310950-B1
优先权日:1983-11-18
标题 :Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes
摘要:Compounds of the types (I) and (II) are disclosed, wherein each R5 is independently selected from the group consisting of alkyl of one to about four carbon atoms, alkoxy of one to about four carbon atoms and halogen, and n is an integer from 0 to 2, with the proviso that if n is 2, then said R5 substituents together contain no more than 6 carbon atoms; R6 is selected from the group consisting of hydroxyalkyl of one to about six carbon atoms and cyclohexylmethyl; and R7 is selected from the group consisting of alkyl of one to about four carbon atoms and hydrogen. These compounds may be used as intermediates for the synthesis of 1H-imidazo[4,5-c]quinoline derivatives.

专利号:US-6201168-B1
优先权日:1999-08-20
标题:Pathogenesis of cardiomyopathy
发明人：CAMPBELL KEVIN P; CORAL RAMON; COHN RONALD; WILLIAMSON ROGER; DURBEEJ MADELEINE
权利人:UNIV IOWA RES FOUND
摘要:Disclosed is a mouse, cells derived therefrom, and methods for using the mouse, the mouse being homozygous for a disrupted Î´-sarcoglycan gene, the disruption in the gene having been introduced into the mouse or an ancestor of the mouse at an embryonic stage. The disruption prevents the synthesis of functional Î´-sarcoglycan in cells of the mouse and results in the mouse having a reduced amount of Î²- and Îµ-sarcoglycan and sarcospan, and a disruption of the sarcoglycan-sarcospan complex in smooth muscle of the mouse. Also disclosed is a mouse, cells derived therefrom, and methods for using the mouse, the mouse being homozygous for a disrupted Î²-sarcoglycan gene, the disruption in the gene having been introduced into the mouse or an ancestor of the mouse at an embryonic stage. The disruption prevents the synthesis of functional Î²-sarcoglycan in cells of the mouse and results in the mouse having a reduced amount of Î´-and Îµ-sarcoglycan and sarcospan and Î±-dystroglycan in smooth muscle of the mouse.

专利号:US-2007172520-A1
优先权日:2005-11-18
标题:Immunotargeting of Nonionic Surfactant Vesicles
发明人：VANAUKER MICHAEL; PLAAS ANNA; HOOD ELIZABETH
权利人:UNIV SOUTH FLORIDA
摘要:An immunoniosmes for targeted delivery of therapeutic agents to specific tissues in a host and methods of synthesis of those niosomes. An antibody molecule having specificity for a target antigen, such as a cell surface marker or other marker differentially expressed on a target cell, is covalently coupled to a functionalized membrane constituent. In a particular embodiment the functionalized membrane constituent is polyoxyethylene sorbitan monostearate functionalized with cyanuric chloride. The niosomes of this invention thus provide a composition that enhances internalization or retention of the bioactive agent of the niosome into the cytoplasm of the cells of the target tissue by providing a high degree of target specificity. Furthermore, the membrane vesicle enhances the life of the therapeutic agent by preventing its degradation in the extracellular environment, while exhibiting lower toxicity than can occur with some liposomes. The niosomes of the present invention are thus particularly useful as vehicles for the delivery of therapeutics to specific target cells.

专利号:US-3717711-A
优先权日:1970-06-22
标题:Reducing fatty acid synthesis with a diet containing xylitol
发明人：MILLER O
权利人:HOFFMANN LA ROCHE
摘要:THE INHIBITION OF FATTY ACID SYNTHESIS IS OBTAINED IN BIOLOGICAL SYSTEMS BY UTILIZING XYLITOL AS A REPLACEMENT FOR OTHER CARBOHYDRATES IN THE DIET. THE PRESENT METHOD INVOLVES THE INHIBITION OF THE LIPOGENIC ENZYME ACTIVITIES WITH RESULTANT INHIBITION OF FATTY ACID SYNTHESIS. INHIBITITION OF FATTY ACID SYNTHESIS BY THE PRESENT METHOD IS USEFUL IN THE TREATMENT OF OBESITY AND IN CORRECTING CONDITIONS OF LIPID ABNORMALITIES.

专利号:US-3764692-A
优先权日:1970-09-30
标题 :Method of treating obesity
发明人：LOWENSTEIN J
权利人:HOFFMANN LA ROCHE
摘要:The inhibition of fatty acid synthesis is obtained in biological systems by utilizing a specific stereoisomer of hydroxycitric acid and derivatives thereof such as esters or lactones and the non-toxic salts of these compounds. It is believed that the present method involves the inhibition of citrate cleavage enzyme. Inhibition of fatty acid synthesis by the present method is useful in the treatment of obesity.

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合成参考文献

摘要:Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure, Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982, -(53), 1982
摘要:Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases., 22(7)(55), 1978
摘要:
摘要:
摘要:NIOSH. NIOSH Pocket Guide to Chemical Hazards & Other Databases. U.S. Department of Health & Human Services, Public Health Service, Center for Disease Control & Prevention. DHHS (NIOSH) Publication No. 2001-145 (CD-ROM) August 2001.

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