合成目标产物 2-Ethylhexyl Acetate 主要起始原料 2-Ethylhexanol And Methyl Acetate
(文献来源)合成步骤主要原料 2-Ethylhexanol 和 Methyl Acetate
2-乙基-1-己烯置于吡啶,二氯二茂锆,氧气,二异丁基氯化铝体系中,化学反应 8.0H,反应生成醋酸-2-乙基己酯 参考文献:Regioselective Hydroalumination Of Unsaturated Hydrocarbons By Alkylalanes Catalyzed By Zirconium Complexes 标题:Regioselective Hydroalumination Of Unsaturated Hydrocarbons By Alkylalanes Catalyzed By Zirconium Complexes 摘要: Doi:10.1007/bf00956355
专利信息
专利号:US-8647848-B2 优先权日:2008-06-13 标题:Enzymatic synthesis of sphingolipids 发明人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS 权利人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS; EVONIK GOLDSCHMIDT GMBH 摘要:The invention relates to the enzymatic synthesis of sphingolipids and compositions that contain sphingolipids from lysosphingolipids and carbonic esters, and to cosmetic, dermatological or pharmaceutical formulations containing said sphingolipids or compositions.
专利号:US-2005119332-A1 优先权日:1998-03-12 标 题 :Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) 发明人:JEPPESEN LONE; ANDERSEN HENRIK S; OLSEN OLE H; JUDGE LUKE M; HOLSWORTH DANIEL D; BAKIR FARID; AXE FRANK U; GE YU 摘要:The present invention provides novel compounds of formula 1a, n nnovel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.
专利号:US-2002165398-A1 优先权日:1998-03-12 标题:Modulators of protein tyrosine phosphatases (PTPases) 发明人:JEPPESEN LONE; ANDERSEN HENRIK SUNE; OLSEN OLE HVILSTED; JUDGE LUKE MILBURN; HOLSWORTH DANIEL DALE; BAKIR FARID; AXE FRANK URBAN; GE YU 摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. n The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimers disease and schizophrenia, and infectious diseases.
专利号:US-5663480-A 优先权日:1993-12-20 标题:Synthesis of aromatic carbonates by transesterification using a catalyst comprising a microporous material and a group IV metal 发明人:TSUNEKI HIDEAKI; KIRISHIKI MASARU; WATANABE KENICHI; ONDA YOSHIYUKI 权利人:NIPPON CATALYTIC CHEM IND 摘要:A catalyst for producing an aryl ester of a carbonic or carboxylic acid is disclosed, which includes a microporous material containing a metal element belonging to group IV. This catalyst can be used as a heterogeneous catalyst to produce the aryl ester in high yield with industrial advantages. In order to produce the aryl ester using the catalyst, a carbonate or an aliphatic carboxylate is transesterified with an aromatic hydroxy compound, or an aryl carboxylate is transesterified with a carbonate, or an alkyl aryl carbonate is disproportionated by transesterification.
专利号:US-5210222-A 优先权日:1991-01-21 标题 :Process for the production of malonic acid anhydride 发明人:O'MURCHU COLM 权利人:LONZA AG 摘要:A process, which is harmless with respect to safety, for the production of malonic acid anhydride. For this purpose, diketene is ozonized in the presence of a suitable carbonyl compound. Malonic acid anhydride is a highly reactive intermediate product for the synthesis of numerous active ingredients for, e.g., pharmaceutical agents, pesticides or dyes.
专利号:US-4980291-A 优先权日:1988-02-10 标 题 :Process for the enzymatic separation of the optical isomers of racemic α-alkyl-substituted primary alcohols 发明人:BIANCHI DANIELE; CESTI PIETRO; FRANCALANCI FRANCO; CABRI WALTER 权利人:DONEGANI GUIDO IST 摘要:Biotechnological resolution by means of enzymatic transesterification of the relevant racemic mixture of the optical isomers of α-alkyl-substituted primary alcohols having the formula (I): ##STR1## wherein: R represents a linear or branched (C 1 -C 20 )-alkyl or alkenyl group or an aryl group, also substituted or condensed with other groups, in particular a group of formula (II) or (III): ##STR2## wherein: R ii represents a (C 1 -C 8 )-alkyl group, a (C 1 -C 4 )-alkenyl group, an alkoxy, phenyl, phenoxy, benzoyl, or heterocyclic group; n R iii represents a hydrogen or halogen atom; n R iv represents a (C 1 -C 4 )-alkyl group, n and wherein n R i represents a (C 1 -C 4 )-alkyl group either equal to, or different from, R, n in the presence of an enzyme either free or immobilized on a support capable of selectively causing the S isomer to be esterified, with the R isomer being left substantially unchanged, said isomers being then separated according to techniques known from the prior art. The process is used in the synthesis of antiinflammatory agents.
[参考文献]: Shinobu Oda, Et Al. Efficient Hydrolytic Reaction Of An Acetate Ester With Fungal Lipase In A Liquid-Liquid Interface Bioreactor (L-L Ibr) Using Caco-Coated Ballooned Microsphere. J Biosci Bioeng. 2011 Aug;112(2):151-3.
合成参考文献
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