CAS: 1067-71-6; Diethyl (2-Oxopropyl)Phosphonate

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CAS号78-95-5 氯丙酮 | CAS号122-52-1 亚磷酸三乙酯 | CAS号5954-65-4 (2-丙烯基)膦酸二乙酯 | CAS号2466-76-4 1-乙酰基咪唑 | CAS号3095-95-2 二乙基磷乙酸 | CAS号683-08-9 甲基膦酸二乙酯 | CAS号1067-88-5 1-diethoxyphosp... | CAS号1067-87-4 烯丙基磷酸二乙酯 | CAS号51533-70-1 (2-甲基烯丙基)膦酸二乙酯 | CAS号38186-51-5 4-溴苄基亚磷酸二乙酯 | CAS号1896-62-4 反式苯亚甲基丙酮 | CAS号555-16-8 对硝基苯甲醛 | CAS号152401-77-9 (E)-2-Diethoxyp... | CAS号28660-33-5 Phosphonicacid,... | CAS号63909-58-0 (4-氟苄基)膦酸二乙酯 | CAS号53575-08-9 1-萘基甲基膦酸二乙酯 | CAS号1080-32-6 苄基膦酸二乙酯 | CAS号22894-35-5 1-diethoxyphosp... | CAS号3453-00-7 (2-氧代-2-苯乙基)膦酸二乙酯

乙基2-二乙氧基磷酰-3-氧代丁酸酯置于水体系中,化学反应生成丙酮基膦酸二乙酯
参考文献:Levuglandin E2 非对映异构体的简化合成
标题:Levuglandin E2 非对映异构体的简化合成
摘要:摘要 我们报告了 Levuglandin E2 的合成,作为易于分离的非对映异构体 (15-E2-Isoketals) 的混合物.关键特征是将其反应性醛保护为二甲基乙缩醛,通过 2,2-二甲氧基乙醛引入,并在几分钟内用蒙脱石 K-10 去除.合成可以修改为具有稳定同位素或放射性标记的 15-E2-Isoketals 的制备.
Doi:10.1081/scc-200048945

专利信息

专利号:US-9150498-B2
优先权日:2011-10-25
标题:Process for the preparation of oseltamivir and methyl 3-epi-shikimate
发明人：RAWAT VARUN; DEY SOUMEN; ARUMUGAM SUDALAI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses high yielding enantioselective process for synthesis of Oseltamivir from readily available starting material, cis-1,4-butene diol. The process features incorporation of chirality using sharpless asymmetric epoxidation (AE) and diastereoselective Barbier allylation and construction of cyclohexene carboxylic acid ester core through a ring closing metathesis (RCM) reaction. Further also disclosed herein is synthesis of (−)-methyl 3-epi-shikimate.

专利号:WO-2024262824-A1
优先权日:2023-06-20
标 题 :Novel process for synthesis of polysubstituted pyridine derivatives
发明人：PARK SEUNG BUM; YI SIHYEONG
权利人:SEOUL NAT UNIV R&DB FOUNDATION
摘要:The present invention relates to a novel method for synthesizing a polysubstituted pyridine derivative and, more specifically, to a method for synthesizing a 2,3,5-substituted pyridine derivative through a specific ring cleavage reaction. In the synthesis method of the present invention, an enamine structure is formed in situ by using beta keto ester/sulfone/phosphonic acid ester and ammonium acetate and subjected to an aldol condensation reaction with 3-formyl (aza) indole/benzofuran, a cyclization reaction, and a ring-cleavage reaction in that order to synthesize a characteristic pyridine structure having an alkyl/aryl substituent attached to the 2-position thereof, an ester/sulfone/phosphonic acid ester attached to the 3-position thereof, and ortho-aminoaryl/phenol including various substituents attached to the 5-position thereof. In particular, (aza)indole/benzofuran and beta keto ester/sulfone/phosphonic acid ester, which are reaction substrates, are substrates having very high accessibility, and enable the introduction of various substituents, thereby constructing a pyridine skeleton having high biocompatibility into which ortho-aminoaryl or phenol substituents having various substituents are introduced.

专利号:US-2008242877-A1
优先权日:2007-02-26
标题 :Intermediates and processes for the synthesis of Ramelteon
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L
摘要:Provided are intermediates and processes for preparation of Ramelteon.

专利号:US-6878665-B2
优先权日:2001-09-28
标题:Diphosphines, their complexes with transisition metals and their use in asymmetric synthesis
发明人：DUPRAT DE PAULE SEBASTIEN; CHAMPION NICOLAS; VIDAL VIRGINIE; GENET JEAN-PIERRE; DELLIS PHILIPPE
权利人:SYNKEM
摘要:The invention relates to novel diphosphines, in optically pure or racemic form, of formula (I): n n nin which:n R 1 and R 2 are a (C 5 -C 7 )cycloalkyl group, an optionally substituted phenyl group or a 5-membered heteroaryl group; and A is (CH 2 —CH 2 ) or CF 2 . nn The invention further relates to the use of a compound of formula (I) as a ligand for the preparation of a metal complex useful as a chiral catalyst in asymmetric catalysis, and to the chiral metal catalysts comprising at least one ligand of formula (I).

专利号:US-4145510-A
优先权日:1976-06-21
标 题:5-Substituted phosphonate hydantoins and derivatives thereof
发明人：HALL LUTHER A R; GORDON DAVID A
权利人:CIBA GEIGY CORP
摘要:Hydantoins of the formula wherein R1 is hydrogen or alkyl of 1 to 8 carbon atoms, R2 is R3 is alkyl of 1 to 8 carbon atoms, and X is a straight or branched chain alkylene of 1 to 4 carbon atoms or a straight or branched chain alkylene of 3 to 6 carbon atoms containing an internal carbamido group; or R1 and R2 together are Y where Y is a straight or branched chain alkylene of 4 to 8 carbon atoms having a pendant ARE PREPARED BY REACTING FIRST alpha , beta -UNSATURATED ALDEHYDES OR KETONES WITH ALKYL PHOSPHITES TO FORM A PHOSPHONATE ALDEHYDE OR KETONE FOLLOWED BY A CLASSICAL Bucherer hydantoin synthesis.

专利号:US-8030466-B2
优先权日:2009-09-29
标 题:3′-o-fluorescently modified nucleotides and uses thereof
发明人：SHIN DONGYUN; AHN DAE-RO; AHN HE-CHUL
权利人:KOREA INST SCI & TECH
摘要:The present invention relates to a DNA sequencing method using a nucleoside triphosphate with a fluorescent blocking group on its 3′-OH end as a reversible terminator. Further, the present invention relates to sequencing-by-synthesis method using the mono-modified reversible terminator (MRT), the novel nucleotide monomer having a reversible fluorescent blocking group removable chemically or enzymatically at its 3′-OH end. The sequencing method of the present invention facilitates sequencing of bases inserted by terminating extension of a nucleotide chain by the nucleotide monomer and then detecting fluorescence signal from 3′-OH end. At this time, after analyzing the fluorescence signal, the blocking group conjugated to the 3′-OH end can be effectively removed, indicating that a free 3′-OH functional group can be successfully restored, so that the next monomer insertion is possible, making continuous sequencing possible.