CAS: 13472-79-2; 5-Iodopyridin-2(1H)-One

该化合物是一个异环化合物,在丙烯酮环的5个位置上有一个替代碘的碘替代物.这一结构使该化合物成为有机合成中有价值的中间体,特别是在交叉反应中,如铃木-宫浦和索诺加希拉的联结,碘碘会是进一步功能化的被动处理器.它的丙烯酮核心还有助于其在药用化学中的用途,作为生物活性分子发展的鱼头.该化合物的稳定性和定义明确的再活性特征增强了其在制药和农用化学研究中的可应用性.建议对受控制条件下的处理,因为其对光和湿度的敏感性.

英文名称5-Iodopyridin-2(1H)-One
中文名称2-羟基-5-碘吡啶
IUPAC名称5-iodopyridin-2(1H)-one
其它别名5-Iodo-2-pyridinol
CAS编号13472-79-2
MFCD编号:MFCD00234058
EINECS号:626-943-3
分子式:C5H4INO
分子量:221.0
产品CID: 530930
产品分类医药中间体 → 吡啶类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: ZDJUNNCVIDKJAN-UHFFFAOYSA-N
InChI=1S/C5H4INO/c6-4-1-2-5(8)7-3-4/h1-3H,(H,7,8)…
计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数0.0

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼损伤类别1
严重眼刺激类别2
警示词Danger(危险)
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H318 |造成严重眼损伤.
H319 |造成严重眼刺激.
防范说明P261-P264-P280-P301+P312-P302+P352-P305+P351+P338
危险等级IRRITANT
UN编号NONH for all modes of transport
危险品标志Xn,Xi
安全声明26-36/39
危险类别码22-37/38-41
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号142-08-5 2-羟基吡啶 | CAS号20511-12-0 2-氨基-5-碘吡啶 | CAS号504-29-0 2-氨基吡啶 | CAS号33630-94-3 5-氨基-2-羟基吡啶 | CAS号13472-80-5 3,5-二碘吡啶-2-醇

合成工艺路线路线简述

2-氨基-5-碘吡啶置于硫酸,Sodium Nitrite体系中,化学反应生成2-羟基-5-碘吡啶
参考文献:Magidson; Menschikow,Chemische Berichte,1925,Vol. 58,P. 116
标题:Magidson; Menschikow,Chemische Berichte,1925,Vol. 58,P. 116

海关参考信息

2933310010-吡啶
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-9321213-A1
优先权日:1992-04-16
标题 :Alpha-aminoboronic acid peptides and their use as elastase inhibitors
发明人：BERNSTEIN PETER ROBERT; SHAW ANDREW; SHENVI ASHOKKUMAR BHIKKAPPA; THOMAS ROYSTON MARTIN; WARNER PETER; WOLANIN DONALD JOHN
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic derivatives which are 1-pyridylacetamide derivatives of formula (I), set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases on mammals in which (HLE) is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic derivatives, processes for preparing the heterocyclic derivatives, pharmaceutical compositions containing such heterocyclic derivatives and methods for their use.

专利号:CN-111170991-B
优先权日:2014-07-11
标题 :Antiproliferative compounds and methods of synthesis thereof