CAS: 13623-25-1; 6-Methoxy-1-Indanone

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反式-4-甲氧基肉桂酸置于palladium On Activated Charcoal Ppa,氢气,溶剂黄146体系中,用 甲醇 用作溶剂,120.0 °C,310.27 Kpa 条件下,反应 1.08H,反应生成6-甲氧基-1-茚酮
参考文献:茚三酮的合成路线.茚三酮,5-甲氧基茚三酮和 5-(甲硫基)茚三酮的制备
标题:茚三酮的合成路线.茚三酮,5-甲氧基茚三酮和 5-(甲硫基)茚三酮的制备
摘要:摘要 描述了 5-甲氧基茚三酮(2,2-二羟基-5-甲氧基-1,3-茚二酮)的两种合成方法.一种方法采用一种新颖且有效的两步法,从市售的 6-甲氧基-1-茚满酮开始.还介绍了这种策略在制备新的茚三酮衍生物,5-(甲硫基)茚三酮和茚三酮中的应用.
Doi:10.1080/00397919108055457

专利信息

专利号:US-8084630-B2
优先权日:2007-05-31
标 题 :Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL; TEVA PHARMA
摘要:The present invention provides processes and intermediates for the synthesis of ramelteon.

专利号:US-2010152468-A1
优先权日:2008-10-16
标 题 :Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; JADAV ARPAN M; DADHANIYA PRATISH; NALAWADE JITENDRA
权利人:TEVA PHARMA
摘要:The present invention provides processes and intermediates for the synthesis of ramelteon.

专利号:US-7262326-B2
优先权日:2004-09-08
标 题:Process for the synthesis of indanylamine or aminotetralin derivatives and novel intermediates
发明人：BLANCHET SYLVIE; BLANDINE BERTRAND; BURGOS ALAIN; DERRIEN YVON; MOREAU MARIE-LAURE
权利人:TEVA PHARMA
摘要:A process for preparing indanylamine and aminotetralin derivatives from indanone or tetralone oximes by acylating the oximes with an organic anhydride, followed by catalytic hydrogenation in the presence of an organic anhydride with subsequent hydrolysis is described. The process is commercially feasible providing indanylamine and aminotetralin derivatives in high yield that are useful as intermediates in the production of therapeutically active compounds. Also described are novel intermediates, 1-indanone O-acetyl oximes and 1-tetralone O-acetyl oximes.

专利号:US-6166031-A
优先权日:1987-10-19
标 题:Substituted tetralins, chromans and related compounds in the treatment of asthma
发明人：EGGLER JAMES F; MARFAT ANTHONY; MELVIN JR LAWRENCE S
权利人:PFIZER
摘要:Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals; pharmaceutical compositions comprising said compounds; a method of treatment with said compounds; and intermediates useful in the synthesis of said compounds.

专利号:US-2009281176-A1
优先权日:2007-11-01
标题:Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
摘要:A process for the preparation of ramelteon and intermediates useful in the process. The process suitable for industrial scale provides increased yield and/or greater purity with fewer process steps.

专利号:US-7884243-B2
优先权日:2003-12-22
标 题:Process for the synthesis of eneamide derivatives
发明人：BURGOS ALAIN; BERTRAND BLANDINE; ROUSSIASSE SONIA; PLUVIE JEAN-FRANCOIS; BLANCHET SYLVIE; MARTIN JULIETTE; PERRIN FLORENCE; BOURDEAU FRANCOISE
权利人:ZACH SYSTEM
摘要:A process for the production of ene-amide derivatives represented by the formula (I) n nwherein R1 and R2 and R3 are independently a hydrogen atom, an alkyl, a cycloalkyl, a cycloalkylalkyl, an alkylaryl, an aryl, a heterocycle, a cyano, an alkoxy, an aryloxy, a carboxyl, a carbamoyl, —CONR5R6 (in which R5 and R6 are independently an alkyl, arylalkyl or aryl group said ring being substituted or not with a functional group or with R5) or —COOR5 group (in which R5 is an alkyl, alkylaryl or aryl group), said alkyl, cycloalkyl, cycloalkylalkyl, alkylaryl and aryl groups being substituted or not with a functional group or with R5; or R1 and R2 taken together, may form a ring (which terms includes mono-, di- and higher polycyclic ring systems); R4 is a hydrogen atom, an alkyl, an aryl, an alkylaryl, said groups are substituted or not with a halogen atom as Cl, Br, or F; X is an oxygen atom or a leaving group and m is an integer 1 or 2; when m is 1 then X is a leaving group; when m is 2 then X is a oxygen atom, which comprise: a hydrogenation/isomerization reaction in presence of a heterogeneous catalyst, of an oxime derivatives of formula (II)n n nwherein R1, R2 and R3 are as defined above with an acyl derivative of formula (III) (R4CO) m X wherein R4, m and X are as defined above.