专利号:US-2025281418-A1 优先权日:2021-08-11 标题:Lipid nanoparticle formulations and methods of synthesis thereof 发明人:SMITH MICHAEL H 权利人:MODERNATX INC 摘要:Stabilized formulations of lipids and nucleic acids, including lipid nanoparticle formulations which encapsulate nucleic acids are disclosed herein. Methods of using the formulations are also provided.
专利号:EP-1817428-B1 优先权日:2004-11-30 标题 :A method for increasing the specificity of enzymatic dna synthesis 发明人:IGNATOV KONSTANTIN; KRAMAROV VLADIMIR 权利人:BIOLINE LTD 摘要:The invention provides a method of performing a DNA polymerase reaction by including in a reaction mixture containing a DNA polymerase a compound of the formula (I): wherein: R 1 , R 2 , R 3 , R 4 , R 5 may be the same or different and are independently selected from the group consisting of -, -OH, -F, -Cl, -Br, -CF 3 -CCl 3 , - CBr 3 , -NH 2 , -NO 2 , -CN, -CONH 2 , -CHO, -CO 2 H , -SH, -SO 3 H, -OPO 3 H 2 and a group R 7 , R 6 is selected from the group consisting of -0-, -OPO 3 H 2 , -CF 3 , -CCl 3 , -CBr 3 , -CN, -CONH 2 , -CHO, -CO 2 H, and a group R 7 ; each group R 7 is independently selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, or an aryl or heteroaryl ring containing from 5 to 8 ring members, which in the case of heteroaryl rings may include 1 or 2 nitrogen, oxygen or sulphur atoms or mixtures thereof, the remainder being carbon, and wherein R 7 is optionally be substituted by from 1 to 4 groups selected from -OH, -F, -Cl, -Br, -I, -CF 3 - CCl 3 , -CBr 3 , -NH-NH 2 , -NH 2 , -NO, -NO 2 , -CN, -CONH 2 , -CHO, -CO 2 H , - SH, -SO 3 H, -OPO 3 H 2 , or mixtures thereof, and further optionally R 7 may comprise a group -NH-NH-, -NN-, -NH-, -CO-, -S-S-. Kits comprising a DNA polymerase and compounds of the formula (I) also form part of the invention.
专利号:TW-I412587-B 优先权日:2009-12-10 标题:A Method for Synthesis of Fatty Acid Methyl Esters by Water Resistant Acidic Ionic Liquids
专利号:ES-2709217-T3 优先权日:2012-06-22 标 题:Enzymes and methods for the synthesis of styrene
专利号:IT-MI951208-A0 优先权日:1995-06-08 标题 :SYNTHESIS PROCESS OF 1-PYRIDINIOPROPAN-3-SULFONATE
专利号:CN-205740837-U 优先权日:2016-07-08 标 题 :A kind of synthesis system of PPS
[参考文献]: Ann Thanawastien, Et Al. Conjugate-Like Immunogens Produced As Protein Capsular Matrix Vaccines. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1143-51. [参考文献]: Christopher J Detzel, Et Al. Bovine Immunoglobulin/protein Isolate Binds Pro-Inflammatory Bacterial Compounds And Prevents Immune Activation In An Intestinal Co-Culture Model. Plos One. 2015 Apr 1;10(4):E0120278. [参考文献]: Jennifer F Carr, Et Al. Engineering The Genome Of Thermus Thermophilus Using A Counterselectable Marker. J Bacteriol. 2015 Mar;197(6):1135-44. [参考文献]: Juan Pablo Lopez, Et Al. Biomarker Discovery: Quantification Of Micrornas And Other Small Non-Coding Rnas Using Next Generation Sequencing. Bmc Med Genomics. 2015 Jul 1:8:35. [参考文献]: S Rudnick-Glick, Et Al. Near Ir Fluorescent Conjugated Poly(Ethylene Glycol)Bisphosphonate Nanoparticles For In Vivo Bone Targeting In A Young Mouse Model. J Nanobiotechnology. 2015 Nov 14:13:80.
合成参考文献
参考文献:10.1159/000439113 摘要:Büsing I, Höffken HW, Breuer M, Wöhlbrand L, Hauer B, Rabus R. Molecular Genetic and Crystal Structural Analysis of 1-(4-Hydroxyphenyl)-Ethanol Dehydrogenase from 'Aromatoleum aromaticum' EbN1. J Mol Microbiol Biotechnol. 2015;25(5):327–39. doi: 10.1159/000439113.