CAS: 17694-68-7; 3-(2-Bromoacetyl)Pyridine Hydrobromide

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上下游产品

CAS号350-03-8 3-乙酰吡啶 | CAS号18820-82-1 吡啶氢溴酸盐 | CAS号51746-85-1 3-(1H-咪唑-4-基)吡啶 | CAS号1143459-81-7 N-(2-甲基-5-硝基苯基)... | CAS号118838-57-6 3-Pyridinemetha... | CAS号91800-29-2 2-丙氨基-1-吡啶-3-乙醇 | CAS号46142-84-1 [2-(3-piperidyl... | CAS号60699-67-4 3-(oxiran-2-yl)...

3-乙酰基吡啶置于氢溴酸,溴体系中,化学反应 3.0H,以80%的收率获得3-(2-溴乙酰基)吡啶氢溴酸盐
参考文献:发现新型强效人类软骨肉瘤 (Sw1353) 抑制剂:4-(2/3/4-吡啶基)噻唑 2-乙酰胺衍生物
标题:发现新型强效人类软骨肉瘤 (Sw1353) 抑制剂:4-(2/3/4-吡啶基)噻唑 2-乙酰胺衍生物
摘要:软骨肉瘤是成人患者中最常见的软骨肉瘤.主要是在细胞应激情况下软骨细胞降解后观测到的.不幸的是,由于转移,患者的死亡率很高.在这项研究中,我们发现了一些新的 4-(2/3/4-吡啶基)噻唑2-乙酰胺衍生物,并使用色谱和光谱方法阐明了它们的结构.合成化合物的抗肿瘤活性谱是在软骨肉瘤 (Sw1353) 细胞系上使用 Mtt 测定和凋亡途径 (Bax,Bcl-2) 进行的.此外,还进行了酪氨酸激酶活性研究,以了解潜在的作用机制.在合成的化合物中,有一些化合物对软骨肉瘤细胞表现出优异的活性.除了,化合物对健康的成纤维细胞 (L929) 细胞系没有细胞毒性.在这些化合物中,具有苯并咪唑部分的化合物的 Ic 活性最高与多柔比星 (5.05+/-1.07 µm) 相比,50值为 2.03+/-1.05 µm.结果表明,这些化合物的抗癌活性可能取决于酪氨酸激酶的抑制作用.该化合物还表现出诱导软骨肉瘤细胞凋亡.形态学和菌落观察也成功地可视化.
Doi:10.1016/j.Molstruc.2022.134260

专利信息

专利号:US-6403776-B1
优先权日:2000-07-05
标题 :Synthesis of carbamate ketolide antibiotics
发明人：RIPIN DAVID H B; VANDERPLAS BRIAN C; KANEKO TAKUSHI; MCMILLEN WILLIAM T; MCLAUGHLIN ROBERT W
权利人:PFIZER
摘要:The invention relates to a method of preparing a macrolide antibiotic of the formula n wherein R 1 , R 2 , R 3 , R 4 , R 5 are defined above. These antibiotics are useful as antibacterial and antiprotozoal agents in mammals, including man, as well as in fish and birds. The invention also includes novel compounds made by the preparation of the macrolide antibiotic.

专利号:WO-2015088565-A1
优先权日:2013-12-13
标题:P2x4 receptor modulating compounds and methods of use thereof
发明人：NEWCOM JASON S; SPEAR KERRY L
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are P2X4 receptor modulating compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including but not limited to, chronic pain, neuropathy, inflammatory diseases and central nervous system disorders.

专利号:EP-1088828-A2
优先权日:1999-09-29
标题:Synthesis of carbamate ketolide antibiotics