CAS: 19745-07-4; 2,5-Dichloropyrazine

该化合物是一种杂交有机化合物,其特点是2和5个位置上有两个氯替代物的双子环;C4H2Cl2N2分子配方,其特点是一种板形结构,其原因是环西龙的芳香性质,有助于其稳定性;该化合物一般没有色素,可粉黄液体或固体,取决于其室内温度的物理状态;2,5-二氯环西龙,因其在合成各种制药和农用化学品时的使用而闻名,因为它具有再活动性,并且有能力参与核生殖器替代反应;它还被用作其他化学化合物生产的中间体;氯原子的存在增强了其电子生物特性,使其成为有机合成中有价值的建筑块;与许多氯化化合物一样,必须处理2,5-二氯西龙,同时顾及与氯化有机物质相关的潜在毒性和环境关切.

英文名称2,5-Dichloropyrazine
中文名称2,5-二氯吡嗪
IUPAC名称2,5-dichloropyrazine
其它别名2,5-Dichloropyrazine; Pyrazine, 2,5-Dichloro-; 2,5-Dichloro-Pyrazine; 2,5-Dichloropyrazine, Aldrichcpr; Sy0
CAS编号19745-07-4
MFCD编号:MFCD04117886
EINECS号:687-948-4
分子式:C4H2Cl2N2
分子量:148.98
产品CID: 1005388
产品分类有机原料→分子砌块→芳杂环类化合物→吡嗪类化合物

相似结构搜索
产品信息参考
InChIKey: JVSDZAGCHKCSGR-UHFFFAOYSA-N
InChI=1S/C4H2Cl2N2/c5-3-1-7-4(6)2-8-3/h1-2H…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数0.0

相似化合物

14508-49-7 4774-14-5 4858-85-9

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别急性毒性类别4(经口)
严重眼损伤类别1
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
严重眼刺激类别2A
警示词Danger(危险)
危险描述H302 |吞咽有害.
H318 |造成严重眼损伤.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xn
安全声明26-39
危险类别码22-41

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 2,5-Dichloropyrazine 主要起始原料 2-Bromo-5-Hydroxypyrazine
(文献来源)合成步骤主要原料 2-Bromo-5-Hydroxypyrazine

2-氯吡嗪4-氧化物置于三氯氧磷体系中,化学反应 1.0H,以37%的收率获得2,5-二氯吡嗪
参考文献:Aryl Sulfonamide And Sulfonyl Compounds As Modulators Of Ppar And Methods Of Treating Metabolic Disorders
标题:Aryl Sulfonamide And Sulfonyl Compounds As Modulators Of Ppar And Methods Of Treating Metabolic Disorders
摘要:芳基磺酰胺和磺酰基化合物作为过氧化物酶体增殖激活受体的调节剂,包含它们的药物组合物,以及使用它们治疗疾病的方法被披露.

专利信息

专利号:US-2005107610-A1
优先权日:2003-11-19
标题 :Synthesis of 2-chloro-3,6-dialkyl pyrazines
发明人：RAPPATH DAVID W
权利人:PFIZER
摘要:A process for the production of 3,6-dialkyl-2,5-piperazinediones is disclosed.

专利号:US-2010004245-A1
优先权日:2006-10-20
标题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：OBALLA RENATA M; DESCHENES DENIS; GAGNON MARC; LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:CA-2546026-A1
优先权日:2003-11-19
标题:Synthesis of 2-chloro-3,6-dialkyl pyrazines

专利号:JP-2007511598-A
优先权日:2003-11-19
标题 :Synthesis of 2-chloro-3,6-dialkylpyrazine

专利号:EP-1687281-A1
优先权日:2003-11-19
标题:Synthesis of 2-chloro-3,6-dialkyl pyrazines

专利号:CN-107460497-A
优先权日:2017-07-07
标题 :Electrochemical catalytic synthesis of acyl-substituted electron-deficient nitrogen-containing heterocyclic compounds