CAS: 39658-41-8; Ethyl 6-Aminonicotinate

相似化合物

113293-71-3 69879-22-7 36052-24-1

上下游产品

6-aminonicotinic acid ethanol 6-aminonicotinic amide 2-[1-(5-Ethoxycarbonyl-pyridin-2-ylamino)-meth-(Z)-ylidene]-succinic acid diethyl ester6-(4-nitro-benzenesulfonylamino)-nicotinic acid ethyl ester 6-aminonicotinic amide 6-amino-nicotinic acid hydrazide pyrimidine-7-carboxylate hydr°ChlorideEthyl 2-methyl-3-ethyl-4-oxo-4H-pyrido1,2-apyrimidine-7-carboxylate hydr°Chloride

6-氯烟酸乙酯置于盐酸,Sodium Azide体系中,用 二甲基亚砜 作为反应溶剂,化学反应 2.0H,反应生成 6-氨基烟酸乙酯
参考文献:Highly Efficient One-Pot Amination Of Carboxylate-Substituted Nitrogen-Containing Heteroaryl Chlorides Via Staudinger Reaction
标题:Highly Efficient One-Pot Amination Of Carboxylate-Substituted Nitrogen-Containing Heteroaryl Chlorides Via Staudinger Reaction
摘要:An Efficient One-Pot Method For The Synthesis Of Tert-Butyl 6-Aminonicotinate (5) Is Described. The Key Transformation Involves Displacement Of The Chloro Group In Tert-Butyl 6-Chloronicotinate (2) With Azide Followed By A Staudinger Reaction. The Scope Of This Methodology Is Further Extended For The Synthesis Of A Series Of Carboxylate-Substituted Heteroaryl Amines. In Particular,We Synthesized Tert-Butyl Carboxylate-Substituted Amino-Pyridine,-Pyridazine,And-Pyrazine. In Addition To One-Pot Conversion,Short Reaction Time,Simplicity Of Operation,Ease Of Purification,And Good Yields Are The Key Advantages Of This Methodology. (C) 2012 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tetlet.2012.11.027

专利信息

专利号:US-4375545-A
优先权日:1981-06-22
标 题 :Process for the synthesis of the nicotinyl ester of 6-aminonicotinic acid
发明人：WARNER JR PAUL L; LUBER JR EDWARD J; SOMERVILLE WILLIAM A; ZUSI F CHRISTOPHER
权利人:WESTWOOD PHARMACEUTICALS INC
摘要:6-Aminonicotinic acid is reacted with an alkali carbonate selected from the group consisting of sodium carbonate and potassium carbonate. The reaction is carried out at elevated temperature and in dimethylformamide. The 6-aminonicotinic acid alkali salt so produced is reacted with 3-chloromethylpyridine hydrochloride. The reaction is carried out at elevated temperature and in dimethylformamide. The desired nicotinyl ester is thus produced.

专利号:CA-1167852-A
优先权日:1981-06-22
标 题 :Process for the synthesis of the nicotinyl ester of 6- aminonicotinic acid

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