CAS: 446273-59-2; 3-Amino-4-Bromo-6-Chloropyridazine

相似化合物

1396762-26-7 933034-94-7 5469-69-2

上下游产品

CAS号5469-69-2 3-氨基-6-氯哒嗪 | CAS号933190-51-3 8-溴-6-氯咪唑并[1,2-B]哒嗪 | CAS号1161847-29-5 6,8-dichloro-im... | CAS号1207625-15-7 6-氯-4-((三甲基甲硅烷基... | CAS号808770-39-0 6-氯-4-甲氧基-3-吡嗪胺 | CAS号933034-89-0 8-BROMO-6-CHLOR... | CAS号64068-00-4 3-氨基-4-甲基-6-氯哒嗪

3-氨基-6-氯哒嗪置于溴,碳酸氢钠体系中,用 甲醇 作为反应溶剂,化学反应 20.0H,以37%的收率获得产物3-氨基-4-溴-6-氯哒嗪
参考文献:设计和评估作为钙动员拮抗剂的杂二价par1-Par2配体.
标题:设计和评估作为钙动员拮抗剂的杂二价par1-Par2配体.
摘要:基于已报道的针对亚型par1和par2的拮抗剂,已经制备了靶向推定的蛋白酶激活受体(par)异聚体的新型二价配体.包含炔连接体的par1拮抗剂rwj-58259的改良版通过环加成反应与连接至基于咪唑并哒嗪的par2拮抗剂的叠氮基封端的聚乙二醇(peg)间隔基连接.对par1-Par2拮抗剂的初步研究表明,它们在par1和par2激动剂驱动的内皮细胞和癌细胞中抑制gαq介导的钙动员.这种新型化合物有望预防再狭窄,癌细胞转移和其他增生性疾病.
DOI:10.1021/acsmedchemlett.8B00538

专利信息

专利号:US-11685761-B2
优先权日:2017-12-20
标 题:Cyclic di-nucleotide compounds as sting agonists
发明人：ANDRESEN BRIAN M; BENNETT FRANK; CHANG WONSUK; CHILDERS MATTHEW LLOYD; CUMMING JARED N; LIM JONGWON; LU MIN; TROTTER BENJAMIN WESLEY; WU WEN-LIAN
权利人:MERCK SHARP & DOHME; ANDRESEN BRIAN M; BENNETT FRANK; CHANG WONSUK; CHILDERS MATTHEW LLOYD; CUMMING JARED N; LIM JONGWON; LU MIN; TROTTER BENJAMIN WESLEY; WU WEN LIAN; MERCK SHARP & DOHME LLC
摘要:A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

专利号:US-2013072495-A1
优先权日:2010-05-14
标 题 :Fused bicyclic kinase inhibitors
发明人：LI AN-HU; MULVIHILL MARK J; STEINIG ARNO G
权利人:LI AN-HU; MULVIHILL MARK J; STEINIG ARNO G; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula I, as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as but not limited to tumors driven at least in part by at least one of RON, MET, IR, IGF-1R, or ALK. This Abstract is not limiting of the invention.

专利号:US-10227344-B2
优先权日:2016-06-24
标题 :CK2 inhibitors, compositions and methods thereof
发明人：WEBBER STEPHEN E; TAO XUELIANG; BRIN ELENA
权利人:POLARIS PHARMACEUTICALS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. n nFor Formula (I) compounds R 1 , R 2 , R 3 , Ar and Z are as defined in the specification. The inventive Formula (I) compounds are inhibitors of CK2 and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer, inflammation and immunological disorders.

专利号:US-8445510-B2
优先权日:2010-05-14
标题 :Fused bicyclic kinase inhibitors
发明人：MULVIHILL MARK J; STEINIG ARNO G; CREW ANDREW PHILIP; JIN MEIZHONG; KLEINBERG ANDREW; LI AN-HU; WANG JING
权利人:MULVIHILL MARK J; STEINIG ARNO G; CREW ANDREW PHILIP; JIN MEIZHONG; KLEINBERG ANDREW; LI AN-HU; WANG JING; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula I, as shown below and defined herein: n n n n n n n n n n pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of RON, MET or ALK. This Abstract is not limiting of the invention.

专利号:CN-105237541-A
优先权日:2015-09-29
标 题 :Synthesis method of 6-cholro-8-bromoimidazole[1,2-b]pyridazine

专利号:CN-120136877-A
优先权日:2023-12-04
标 题 :Synthesis method of 6-chloro-2, 8-dimethylimidazo [1,2-B ] pyridazine