CAS: 54060-30-9; 3-Ethynylaniline

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CAS号69088-96-6 4-(3-氨苯基)-2-甲基-... | CAS号3034-94-4 1-乙炔基-3-硝基苯 | CAS号33432-52-9 2-methyl-4-(3-n... | CAS号591-19-5 3-溴苯胺 | CAS号108-42-9 间氯苯胺 | CAS号585-79-5 间溴硝基苯 | CAS号626-01-7 3-碘苯胺 | CAS号110598-30-6 (3-氨基苯炔基)三甲基硅烷 | CAS号185619-66-3 (3-炔基苯基)氨基甲酸叔丁酯 | CAS号70933-58-3 N-(3-乙炔基苯基)乙酰胺 | CAS号99-03-6 3'-氨基苯乙酮 | CAS号31661-59-3 1,4-双(3-氨基苯)丁二炔 | CAS号15411-43-5 3-乙烯基苯胺 | CAS号2237-30-1 3-氨基苯甲腈 | CAS号179688-29-0 6,7-二甲氧乙氧基喹唑啉-4-酮 | CAS号183319-69-9 盐酸埃罗替尼 | CAS号183321-74-6 埃罗替尼 | CAS号918541-45-4 N-(3-ethynylphe...

3'-溴苯乙炔置于potassium Phosphate,2-(二环己基膦)3,6-二甲氧基-2',4',6'-三异丙基-1,1'-联苯,水,Palladium Diacetate,Sodium Hydroxide体系中,用 乙醇,水,叔丁醇 作为反应溶剂,化学反应 6.5H,反应生成 3-氨基苯乙炔
参考文献:一种间氨基苯乙炔的制备方法
标题:一种间氨基苯乙炔的制备方法
摘要:本发明涉及有机合成领域,特别是涉及一种间氨基苯乙炔的制备方法.本发明提供一种间氨基苯乙炔的制备方法,包括:将式i化合物与式ii化合物偶联反应制备获得式iii化合物;将式iii化合物制备获得式v化合物.本发明所提供的间氨基苯乙炔的制备方法合成路线短,尤其以间溴苯乙炔为原料,经过两步反应即可得到目标产物,能耗少,环境友好.此外,制备获得的间氨基苯乙炔用做为抗癌药物原料,从源头就可以有效避免含有卤素和含有烯键结构的潜在毒性基因杂质的产生.

专利信息

专利号:US-9920160-B2
优先权日:2014-09-03
标题 :Method for synthesis of polymer containing multiple epoxy groups
发明人：GAO CHAO; ZHENG YAOCHEN; PENG LI; CAI SHENGYING; WENG ZHULIN
权利人:UNIV ZHEJIANG
摘要:A method for a synthesis of a polymer containing multiple epoxy groups includes steps of: under protection of nitrogen or argon, with a photosensitive free radical initiator under an ultraviolet light irradiation, initiating a mixture of a dithiol compound and alkynyl glycidyl ether or other alkynyl-containing compounds to proceed a thiol-yne polymerization, so as to obtain the polymer. The number of the epoxy groups is able to be adjusted through changing a type of a dithiol monomer, a mixing ratio of the dithiol monomer, and a mixing ratio between the alkynyl glycidyl ether and other alkynyl compounds. The present invention has advantages of: fast reaction, convenient process, easy post-processing, a large number of the epoxy groups, and adjustable and controllable content. The obtained polymer has a wide potential application in fields of coating, adhesive, ink, encapsulating material, resin for composite material, additive, high performance material, function material, and so on.

专利号:WO-2025101716-A1
优先权日:2023-11-07
标题:Processes for synthesis of trifunctionalized sulfur(vi) compounds
发明人：LOPCHUK JUSTIN; SHULTZ ZACHARY; ATHAWALE PARESH
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure describes processes for the asymmetric synthesis of trifunctionalized sulfur(VI) containing organic compounds of Formula I and Formula VI, as well as compounds of Formula I and Formula VI prepared by the processes described.

专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

专利号:US-9359370-B2
优先权日:2008-07-08
标题 :Icotinib hydrochloride, synthesis, crystalline forms, pharmaceutical compositions, and uses thereof
发明人：WANG YINXIANG; XIE GUOJIAN; DING LIEMING; TAN FENLAI; HU YUNYAN; HE WEI; HAN BIN; LONG WEI; LIU YONG; Ai haima; DAVIS CHARLES; ZHANG DON
权利人:BETA PHARMA INC
摘要:The invention relates to 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, its therapeutic usage for treatment of diseases mediated by EGFR kinase and its combinatory therapeutic usage together with other therapeutic agents. The invention also provides synthetic methods for preparation of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, and the relevant synthetic intermediates for synthesis of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride.

专利号:US-11466046-B2
优先权日:2014-10-08
标题 :14-membered ketolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macrocyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.